Abstract: The present invention relates to a pharmaceutical combination comprising a KRAS G12C inhibitor and one or more therapeutic agents which is selected from an agent targeting the MARK pathway or an agent targeting parallel pathways; and pharmaceutical compositions comprising the same. The invention also relates to KRAS G12C inhibitors alone or said combinations for use in methods of treating a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutant.

Abstract: A method for generating automation for a remote terminal unit, in which automation for the remote terminal unit is generated by a computer-implemented configuration tool in conformance with specifications of the VDI/VDE/NAMUR 2658 standard, so as to subsequent communication of the remote terminal unit with a control system for an industrial plant to operate and monitor the remote terminal unit, where a data communications part of the automation is adapted to the specific requirements of communication of the remote terminal unit with external computing units, and where bidirectional communication mechanisms provided for in the VDI/VDE/NAMUR 2658 standard are each replaced by two unidirectional communication mechanisms.

Abstract: To automate alarm management in modular production installations, provided is, with respect to a modular production installation, for which, for its modular, manufacturer-independent construction and operation, “process equipment assembly” modules, controlled by a programmable PEA controller and simulated by means of a configurable PEA simulation, are integrated into the production installation, by means of a “module type package <MTP>” mechanism for the PEA module description, in the course of a process orchestration which is standardized the following is carried out in the alarm management: —all states of the modular production installation with respect to triggered faults of possible fault cases of the production installation are virtually run through and simulated; —simulation faults that occur are logged concomitantly by means of alarms, which provide identification and an alarm message log is created and/or alarm chains are identified and alarm relationships in the alarm chains are determined.

Abstract: The present invention provides a compound of formula (I), or a pharmaceutically acceptable salt thereof, and the therapeutic uses of said compound. The present invention further provides a pharmaceutical composition comprising said compound.

Abstract: In today's automation systems, there is a close coupling between the functional implementation and the connection thereof to the physical process. This coupling is above all characterised in that the integration possibilities of decentralised periphery are limited to the integration of individual hardware-specific signals. The invention relates to a component-based and function-encapsulating system architecture which overcomes present challenges by associating increasingly more intelligent devices in the field as functional components.

Abstract: A functional module includes at least one technical object for performing a technical process, a control unit which control the technical object based on previously determined rules and interconnections that are being permanently stored in the control unit, a communication unit which interchanges data with external communication partners, wherein the functional module has a configurable logic unit which uses the communication unit to receive additional, variably predefinable rules and interconnections from an external communication partner and to take the additional, variably predefinable rules and interconnections as a basis for supplementing the rules and interconnections previously determined in the control unit with respect to an interaction of the functional module with at least one further functional module.

Abstract: To automate alarm management in modular production installations, provided is, with respect to a modular production installation for which, for its modular, manufacturer—independent construction and operation, “process equipment assembly” modules, controlled by a programmable PEA controller and simulated by means of a configurable PEA simulation, are integrated into the production installation, by means of a “module type package <MTP>” mechanism for the PEA module description, in the course of a process orchestration which is standardized the following is carried out in the alarm management: —all states of the modular production installation with respect to triggered faults of possible fault cases of the production installation are virtually run through and simulated; —simulation faults that occur are logged concomitantly by means of alarms, which provide identification and an alarm message log is created and/or alarm chains are identified and alarm relationships in the alarm chains are determined.

Abstract: A method for generating automation for a remote terminal unit, in which automation for the remote terminal unit is generated by a computer-implemented configuration tool in conformance with specifications of the VDI/VDE/NAMUR 2658 standard, so as to subsequent communication of the remote terminal unit with a control system for an industrial plant to operate and monitor the remote terminal unit, where a data communications part of the automation is adapted to the specific requirements of communication of the remote terminal unit with external computing units, and where bidirectional communication mechanisms provided for in the VDI/VDE/NAMUR 2658 standard are each replaced by two unidirectional communication mechanisms.

Abstract: A method for engineering a method- or process-engineering plant with at least one function module, a corresponding function module and a stored program control, wherein the function module includes the stored program control and the method- or process-engineering module that can be controlled or regulated thereby fur use as part of the plant, where a parameter-configurable user program is loaded into the stored program control, and information for the integration of the function module in a file is provided, during engineering of the plant, which defines the parameters for the application-specific configuration of the function module via a plant-engineering tool and stored via an interface specified in a formal description language, for configuration of the user program, in a memory area of the control such that an engineering tool, which is specific to the respective stored program controls used within function modules, is advantageously no longer required.

Abstract: Method for creating a recipe for a process-related process plant based on at least one service, wherein the at least one service is a representation, in terms of automation technology, of concrete physical embodiments of process-related operations of the process-related process plant, where in order to create the recipe, a substitute object assigned to the service is used for each individual service, the substitute object has a parameterization, via which, when merging the created recipe and a topology of the process-related process plant, the concrete physical embodiments of the process-related operations of the process-related process plant can be incorporated into the recipe, and where the substitute object(s) is/are realized in a programmable logic controller of a control system of the process-related process plant or in a batch system of the control system of the process-related process plant.

Abstract: A method for engineering a method-or process-engineering plant with at least one function module, a corresponding function module and a stored program control, wherein the function module includes the stored program control and the method-or process-engineering module that can be controlled or regulated thereby fur use as part of the plant, where a parameter-configurable user program is loaded into the stored program control, and information for the integration of the function module in a file is provided, during engineering of the plant, which defines the parameters for the application-specific configuration of the function module via a plant-engineering tool and stored via an interface specified in a formal description language, for configuration of the user program, in a memory area of the control such that an engineering tool, which is specific to the respective stored program controls used within function modules, is advantageously no longer required.

Abstract: This invention relates to weighing apparatus of the electromagnetic load compensation type including a load or compensation coil connected with the load receiving member, and a reference coil connected with the frame for movement independent of the load receiving member, characterized in that the load and reference coils are arranged within separate air gaps of the magnetic field produced by a permanent magnet system mounted on the weighing apparatus frame. In one embodiment, the permanent magnet system includes a permanent magnet having a rotationally symmetrical field, and a magnetic yoke arrangement including an annular outer pole shoe arranged in concentrically spaced relation about an inner pole shoe. An annular ferromagnetic member is arranged in concentrically spaced relation between the inner and outer pole shoes for defining the air gaps in which the reference and load coils are arranged, respectively.

Abstract: In a weighing scale in which compensating weights may be attached to or removed from a weighing pan assembly to adjust the combined mass of the assembly, of an object on the weighing pan that is to be weighed, and of the attached compensating weights within range of an indicating device, the adjusting arrangement includes a carrier on which guides defining respective paths of longitudinal sliding movement for the elongated compensating means, and a stop limits the sliding movement of each weight in a fixed, lowermost position, the paths being inclined relative to the horizontal at a preferred angle of 10.degree. - 20.degree..