Abstract: The invention relates to methods for assessing a level of T cell activation by one or more antigens or for assessing functional avidity of T cells for one or more antigens, the methods comprising providing a cell population comprising T cells, contacting said cell population with one or more antigens in vitro, and determining a level of a T-cell receptor (TCR) complex and/or component thereof in a sub-set of T cells of said cell population.

Abstract: In one embodiment a method for hybrid localization in a first area and in a second area comprises the following steps: operating (A) a device in a first mode of operation, while the device is in the first area in which a wireless communication is available, detecting (B) that the device transitions from the first area to the second area in which a short range radio signal transmission is available, switching (C) the device to a second mode of operation upon detection that the device transitions from the first area to the second area, wherein in the first mode of operation the device uses a first technology for localization, wherein in the second mode of operation the device uses at least a second technology for localization in which the device emulates the short range radio signal transmission during at least one idle period of the wireless communication.

Abstract: A method for calibrating a radio-based keyless access system of a transportation vehicle, an access system, and a corresponding transportation vehicle. Based on a measured field strength of an LF field, it is determined whether the signal transmitter is located at most at a specified distance from the transportation vehicle. A second transmission device emits a higher-frequency calibration signal in response to which the signal transmitter transmits a response signal back to the transportation vehicle. A reference distance from the signal transmitter to the transportation vehicle is automatically determined from the propagation time of the calibration signal and the response signal. The measured LF field strength-based determination of whether the signal transmitter is located at most at a specified distance from the transportation vehicle is then calibrated automatically based on the determined reference distance.

Abstract: A reactor configured to clean ballast water on ships includes a reactor housing having an inlet and an outlet and a reactor tube in the reactor housing providing a fluid connection between the inlet and the outlet. The reactor tube includes an inner wall having a plurality of rounded recesses extending longitudinally from a first end of the reactor tube to a second end of the reactor tube, and the rounded recesses each have a substantially constant cross section from the first end of the reactor tube to the second end of the reactor tube. A radially inwardly projecting ridge extends between each circumferentially adjacent pair of the rounded recesses.

Abstract: The performance of an action for a transportation vehicle, wherein a relay attack is prevented. In response to a transmission of a first radio signal at a first frequency, on the one hand, a second radio signal at a second frequency is received from an ID transponder authorized for the transportation vehicle and, on the other hand, a further radio signal at the first frequency is received. The action is performed for the transportation vehicle only in response to the second radio signal originating from an ID transponder authorized for the transportation vehicle and only in response to the signal strength of the further radio signal lying below a predefined signal strength threshold.

Abstract: An apparatus, a key partner, methods and computer programs for a key module of a vehicle and a vehicle. The apparatus for the key module includes a communication interface for radio communication with a key partner of the vehicle, a motion sensor, and a control module for controlling an operating state from operating states of the key module based on the information about the motion of the key module. The operating states include at least a first operating state, a pre-shutdown operating state and a shutdown state. The control module activates the first operating state if the motion of the key module is above a motion limit value and activates the pre-shutdown operating state if the motion of the key module is below the motion limit value over a period of time.

Abstract: This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).

Abstract: For suppression of continuous wave interferers at, e.g., up to four interferer frequencies (f1, f2, f3, f4) in a GNSS receiver base band circuit a raw digital signal is, in a band stop unit (21), shifted, by a first mixer (31a), by the negative of the first interferer frequency (f1) in the frequency domain whereupon the continuous wave interferer is suppressed by a band stop filter (30a), a linear phase FIR filter with a suppression band centered at zero, e.g., a filter subtracting a mean over previous subsequent signal values from the actual signal value. After further shifting of the shifted digital signal by the negative of the difference between the second interferer frequency (f2) and the first interferer frequency (f1) the shifted digital signal is again filtered by an identical band stop filter (30b) and so on.

Abstract: For suppression of continuous wave interferers at, e.g., up to four interferer frequencies (f1, f2, f3, f4) in a GNSS receiver base band circuit a raw digital signal is, in a band stop unit (21), shifted, by a first mixer (31a), by the negative of the first interferer frequency (f1) in the frequency domain whereupon the continuous wave interferer is suppressed by a band stop filter (30a), a linear phase FIR filter with a suppression band centered at zero, e.g., a filter subtracting a mean over previous subsequent signal values from the actual signal value. After further shifting of the shifted digital signal by the negative of the difference between the second interferer frequency (f2) and the first interferer frequency (f1) the shifted digital signal is again filtered by an identical band stop filter (30b) and so on.

Abstract: For suppression of continuous wave interferers at, e.g., up to four interferer frequencies (f1, f2, f3, f4) in a GNSS receiver base band circuit a raw digital signal is, in a band stop unit (21), shifted, by a first mixer (31a), by the negative of the first interferer frequency (f1) in the frequency domain whereupon the continuous wave interferer is suppressed by a band stop filter (30a), a linear phase FIR filter with a suppression band centered at zero, e.g., a filter subtracting a mean over previous subsequent signal values from the actual signal value. After further shifting of the shifted digital signal by the negative of the difference between the second interferer frequency (f2) and the first interferer frequency (f1) the shifted digital signal is again filtered by an identical band stop filter (30b) and so on.

Abstract: This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).

Abstract: This disclosure provides a method of identifying or separating activated regulatory T cells that have a demethylated Foxp3 TSDR region from a mixture of activated T cells. The mixture is depleted of cells bearing the CD154 molecule (CD40 ligand). The desired cells can be recovered using a Treg marker such as CD25, GITR, CTLA4, CD137, latent TGF-beta (LAP), GARP (LRRC32) or CD121a/b. The Treg cells having a demethylated Foxp3 TSDR region can be used, for example for preparation of pharmaceutical compositions for use in treatment.

Abstract: The present invention relates to a method of identifying and separating non-regulatory T-cells (conventional T-cells) from a mixture comprising regulatory T-cells by using of the CD154 molecule (CD40 ligand) through depletion of CD154+ T-cells from the mixture or in combination with additional positive selection of Treg using markers that are specific for regulatory T-cells, such as for example, CD25, GITR, CTLA4 or markers which are specific for activated regulatory T-cells, such as, for example, CD137, “latent TGF-beta (LAP)”, GARP (LRRC32), CD121a/b, thereby generating a cell composition of activated Treg cells. The invention relates also to a kit comprising an antibody for detecting CD154 and at least one additional antibody for detecting markers for activated or non-activated regulatory T-cells. The antibodies can be coupled to a fluorescent dye or magnetic microparticles.

Abstract: A satellite positioning receiver. The receiver comprises: an RF front end, for receiving satellite positioning signals; an analog to digital converter, for sampling the received signals to generate signal samples; a memory; and a processor, for processing the signal samples to derive code-phases and pseudo-ranges and to calculate a position fix. The processor has a first mode in which it is operable to process the samples as they are generated, to calculate the position fix. It also has a second mode in which it is operable to store the samples or the code-phases or pseudo-ranges in the memory for later processing.

Abstract: This invention relates to novel compounds suitable as precursors for the preparation of certain 18F labelled positron emission tomography (PET) tracers. Furthermore the invention relates to the preparation of such precursor molecules and to the preparation of PET tracers by 18F labelling of such precursors.

Abstract: This invention relates to novel compounds suitable for labeling or already labeled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).

Abstract: In a method and a device (12) for actuating a door or flap (1) of a vehicle (10), the door or flap (1), if it is closed, is automatically opened or, if it is open, is automatically closed if a movement of an object with at least one change in direction is detected outside the vehicle (10) and at the same time a key (6) assigned to the vehicle (10) is detected.

Abstract: This invention relates to novel compounds suitable for labelling by 18F and the corresponding 18F labelled compounds themselves, 19F-fluorinated analogues thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by Positron Emission Tomography (PET).

Abstract: A first operator control function is activated if it is detected by means of a first sensor that a first physical variable is higher than a predetermined first threshold value. In a similar way, a second operator control function is activated if it is detected by means of a second sensor that a second physical variable is higher than a predetermined second threshold value. A third operator control function is activated if it is detected by means of the first sensor that the first physical variable is higher than a predetermined third threshold value and if at the same time it is detected by means of the second sensor that the second physical variable is higher than a predetermined fourth threshold value, the third threshold value being higher than the first threshold value.

Abstract: This invention relates to novel compounds suitable as precursors for the preparation of certain 18F labelled positron emission tomography (PET) tracers. Furthermore the invention relates to the preparation of such precursor molecules and to the preparation of PET tracers by 18F labelling of such precursors.