Patents by Inventor Andreas Thon
Andreas Thon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240133881Abstract: Disclosed are various embodiments of a device comprising a synthetic polymeric substrate having a high quality finish upper surface, the upper surface having at least a bilayer coating comprising a first, reflective layer and a second, transparent layer. Also disclosed are kits containing embodiments of the disclosed device and detectable particles. Also disclosed are various embodiments of a method of using the disclosed device and various embodiments of a method of using the disclosed kit.Type: ApplicationFiled: October 19, 2023Publication date: April 25, 2024Inventors: Valerio Pini, Adonis Stassinopoulos, Matthias Mösl, Jesús Óscar Ahumada Heredero, Chloé Alexia Rodriguez, Andreas Thon, Houman Yaghoubi, Scott Rongey
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Patent number: 11519856Abstract: A method for optically detecting biomarkers in a biosensor is disclosed, wherein the optical detection obtains spatially and spectrally resolved optical signals from a sample on a biosensor, and one or more of these spatially and spectrally resolved optical signals can be analyzed in parallel with image acquisition. The image analysis comprises reading data of the acquired images, correcting them to reduce inhomogeneities and noise, localizing particles in the images, characterizing each particle individually to obtain its position and characterization parameters, and classifying the particles based on their characterization parameters. Using the number of particles per class for all the acquired images of the sample, a statistical value is calculated per sample and each statistical value is correlated with an indication of the presence of a biomarker in the sample.Type: GrantFiled: April 3, 2020Date of Patent: December 6, 2022Assignee: Mecwins, S.A.Inventors: Andreas Thon, Valerio Pini, Antonio Salvador-Matar Renteria, Virginia Cebrián Hernando, Carlos García Aguado, Jesús Oscar Ahumada Heredero
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Patent number: 11519843Abstract: Biosensing platform for simultaneous, multiplexed, high throughput and ultra-sensitive optical detection of biomarkers labelled with plasmonic nanoparticles, the platform being provided with a biosensor, a broadband and continuous spectrum illumination source, an optical detector for simultaneously capturing spatially resolved and spectrally resolved the scattering signal of each individual nanoparticle, an autofocus system and an optical system adapted to collect the scattered signal of the biosensor's surface onto the optical detector, the platform being provided with translation means for the optical system and/or the biosensor, such that the optical system and the biosensor can be displaced relative to each other in the three dimensions, and wherein the processing means are adapted to: i) simultaneously capture spatially and spectrally resolved scattering signals from each nanoparticle individually, and ii) to analyze these signals simultaneously with the capture process.Type: GrantFiled: April 3, 2020Date of Patent: December 6, 2022Assignee: MECWINS, S.A.Inventors: Valerio Pini, Andreas Thon, Antonio Salvador-Matar Renteria, Virginia Cebrián Hernando, Carlos García Aguado, Jesús Oscar Ahumada Heredero
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Patent number: 11119227Abstract: When designing detector arrays for diagnostic imaging devices, such as PET or SPECT devices, a virtual detector, or pixel, combines scintillator crystals with photodetectors in ratios that deviate from the conventional 1:1 ratio. For instance, multiple photodetectors can be glued to a single crystal to create a virtual pixel which can be software-based or hardware-based. Light energy and time stamp information for a gamma ray hit on the crystal can be calculated using a virtualizer processor or using a trigger line network and time-to-digital converter logic. Additionally or alternatively, multiple crystals can be associated with each of a plurality of photodetectors. A gamma ray hit on a specific crystal is then determined by a table lookup of adjacent photodetectors that register equal light intensities, and the crystal common to such photodetectors is identified as the location of the hit.Type: GrantFiled: July 14, 2016Date of Patent: September 14, 2021Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Thomas Frach, Andreas Thon
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Publication number: 20200319085Abstract: Biosensing platform for simultaneous, multiplexed, high throughput and ultra-sensitive optical detection of biomarkers labelled with plasmonic nanoparticles, the platform being provided with a biosensor, a broadband and continuous spectrum illumination source, an optical detector for simultaneously capturing spatially resolved and spectrally resolved the scattering signal of each individual nanoparticle, an autofocus system and an optical system adapted to collect the scattered signal of the biosensor's surface onto the optical detector, the platform being provided with translation means for the optical system and/or the biosensor, such that the optical system and the biosensor can be displaced relative to each other in the three dimensions, and wherein the processing means are adapted to: i) simultaneously capture spatially and spectrally resolved scattering signals from each nanoparticle individually, and ii) to analyze these signals simultaneously with the capture process.Type: ApplicationFiled: April 3, 2020Publication date: October 8, 2020Inventors: Valerio PINI, Andreas THON, Antonio SALVADOR-MATAR RENTERIA, Virginia CEBRIÁN HERNANDO, Carlos GARCÍA AGUADO, Jesús Oscar AHUMADA HEREDERO
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Publication number: 20200319102Abstract: A method for optically detecting biomarkers in a biosensor, comprising: simultaneously acquiring (1100) spatially and spectrally resolved images from at least one sample of the biosensor and performing an image analysis (1000) in parallel to the image acquisition (1100); wherein the image analysis (1000) comprises: reading (2100) data of the acquired images; correcting (2200) the data to reduce inhomogeneities and noise of the images; localizing (2300) particles in the images using the corrected data; characterizing (2400) each particle individually to obtain at least its position and characterization parameters; classifying (2500) the particles based on their characterization parameters to obtain particle classes; counting (2600) the particles for each class and acquired image; for each biomarker in each sample, calculating an overall analysis result (2800) comprising calculating at least one statistical value by using the number of particles per class for all the images acquired from the same sample, anType: ApplicationFiled: April 3, 2020Publication date: October 8, 2020Inventors: Andreas THON, Valerio PINI, Antonio SALVADOR-MATAR RENTERIA, Virginia CEBRIÁN HERNANDO, Carlos GARCÍA AGUADO, Jesús Oscar AHUMADA HEREDERO
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Patent number: 10143376Abstract: In a combined system, a magnetic resonance (MR) scanner includes a magnet configured to generate a static magnetic field at least in a MR examination region from which MR data are acquired. Radiation detectors are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region. The radiation detectors include electron multiplier elements having a direction of electron acceleration arranged substantially parallel or anti-parallel with the static magnetic field. In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces disposed on opposite sides of a magnetic resonance examination region, and the radiation detectors include first and second arrays of radiation detectors disposed with the first and second spaced apart magnet pole pieces.Type: GrantFiled: March 26, 2014Date of Patent: December 4, 2018Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Volkmar Schulz, Torsten Solf, Johan Overweg, Andreas Thon
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Publication number: 20160320496Abstract: When designing detector arrays for diagnostic imaging devices, such as PET or SPECT devices, a virtual detector, or pixel, combines scintillator crystals with photodetectors in ratios that deviate from the conventional 1:1 ratio. For instance, multiple photodetectors can be glued to a single crystal to create a virtual pixel which can be software-based or hardware-based. Light energy and time stamp information for a gamma ray hit on the crystal can be calculated using a virtualizer processor or using a trigger line network and time-to-digital converter logic. Additionally or alternatively, multiple crystals can be associated with each of a plurality of photodetectors. A gamma ray hit on a specific crystal is then determined by a table lookup of adjacent photodetectors that register equal light intensities, and the crystal common to such photodetectors is identified as the location of the hit.Type: ApplicationFiled: July 14, 2016Publication date: November 3, 2016Inventors: Thomas FRACH, Andreas THON
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Patent number: 9423511Abstract: When designing detector arrays for diagnostic imaging devices, such as PET or SPECT devices, a virtual detector, or pixel, combines scintillator crystals (10, 20, 40) with photodetectors (12) in ratios that deviate from the conventional 1:1 ratio. For instance, multiple photodetectors can be glued to a single crystal to create a virtual pixel (10, 20, 40) which can be software-based or hardware-based. Light energy and time stamp information for a gamma ray hit on the crystal can be calculated using a virtualizer processor or using a trigger line network and time-to-digital converter logic. Additionally or alternatively, multiple crystals (54) can be associated with each of a plurality of photodetectors (52). A gamma ray hit on a specific crystal is then determined by a table lookup of adjacent photodetectors (52) that register equal light intensities, and the crystal (54) common to such photodetectors (52) is identified as the location of the hit.Type: GrantFiled: April 29, 2008Date of Patent: August 23, 2016Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Thomas Frach, Andreas Thon
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Patent number: 9110174Abstract: A pixellated detector with an enhanced structure enables easy pixel identification even with high light output at crystal edges. A half-pixel shift between scintillator crystals (50) and detector pixels (12) enables the identification of a crystal (50) from four detector pixels (12) instead of nine pixels in case of optical crosstalk. Glass plates without any mechanical structuring may be used as a common substrate (60) for detectors and scintillators.Type: GrantFiled: August 18, 2011Date of Patent: August 18, 2015Assignee: Koninklijke Philips N.V.Inventors: Herfried Karl Wieczorek, Andreas Thon
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Patent number: 9012854Abstract: When employing specular reflective material in a scintillator crystal array, light trapping in the crystal due to repetitive internal reflection is mitigated by roughening at least one side (16) of each of a plurality of pre-formed polished scintillator crystals. A specular reflector material (30) is applied (deposited, wrapped around, etc.) to the roughened crystals, which are arranged in an array. Each crystal array is coupled to a silicon photodetector (32) to form a detector array, which can be mounted in a detector for a functional scanner or the like.Type: GrantFiled: April 26, 2012Date of Patent: April 21, 2015Assignee: Koninklijke Philips N.V.Inventors: Herfried Karl Wieczorek, Andreas Thon, Steven Cooke
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Patent number: 8923588Abstract: A time of flight positron emission tomography apparatus (100) includes a detector (106), a data acquisition system (120), a coincidence system (122) and a reconstructor (129). Various elements of an imaging chain influence the temporal resolution of the system (100) so that positron data collected along different lines of response is characterized by different temporal resolutions. The different temporal resolutions are used to estimate the positions of detected events along their respective lines of response.Type: GrantFiled: July 18, 2007Date of Patent: December 30, 2014Assignee: Koninklijke Philips N.V.Inventors: Thomas Laurence, Jerome J. Griesmer, Jeffrey A. Kolthammer, Andreas Thon, Ralph Brinks, Carsten Degenhardt
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Publication number: 20140206983Abstract: In a combined system, a magnetic resonance (MR) scanner includes a magnet configured to generate a static magnetic field at least in a MR examination region from which MR data are acquired. Radiation detectors are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region. The radiation detectors include electron multiplier elements having a direction of electron acceleration arranged substantially parallel or anti-parallel with the static magnetic field. In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces disposed on opposite sides of a magnetic resonance examination region, and the radiation detectors include first and second arrays of radiation detectors disposed with the first and second spaced apart magnet pole pieces.Type: ApplicationFiled: March 26, 2014Publication date: July 24, 2014Applicant: KONINKLIJKE PHILIPS N.V.Inventors: Volkmar SCHULZ, Torsten SOLF, Johan OVERWEG, Andreas THON
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Patent number: 8723521Abstract: In a combined system, a magnetic resonance (MR) scanner includes a magnet configured to generate a static magnetic field at least in a MR examination region from which MR data are acquired. Radiation detectors are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region. The radiation detectors include electron multiplier elements having a direction of electron acceleration arranged substantially parallel or anti-parallel with the static magnetic field. In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces disposed on opposite sides of a magnetic resonance examination region, and the radiation detectors include first and second arrays of radiation detectors disposed with the first and second spaced apart magnet pole pieces.Type: GrantFiled: July 25, 2013Date of Patent: May 13, 2014Assignee: Koninklijke Philips N.V.Inventors: Volkmar Schulz, Torsten Solf, Johan Overweg, Andreas Thon
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Publication number: 20140084170Abstract: When employing specular reflective material in a scintillator crystal array, light trapping in the crystal due to repetitive internal reflection is mitigated by roughening at least one side (16) of each of a plurality of pre-formed polished scintillator crystals. A specular reflector material (30) is applied (deposited, wrapped around, etc.) to the roughened crystals, which are arranged in an array. Each crystal array is coupled to a silicon photodetector (32) to form a detector array, which can be mounted in a detector for a functional scanner or the like.Type: ApplicationFiled: April 26, 2012Publication date: March 27, 2014Applicant: KONINKLIJKE PHILIPS N.V.Inventors: Herfried Karl Wieczorek, Andreas Thon, Steven Cooke
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Patent number: 8598532Abstract: An apparatus comprises a plurality of radiation conversion elements (32) that convert radiation to light, and a reflector layer (34) disposed around the plurality of radiation conversion elements. The plurality of radiation conversion elements may consist of two radiation conversion elements and the reflector layer is wrapped around the two radiation conversion elements with ends (40, 42) of the reflector layer tucked between the two radiation conversion elements. The reflector layer (34) may include a light reflective layer (50) having reflectance greater than 90% disposed adjacent to the radiation conversion elements when the reflector layer (34) is disposed around the plurality of radiation conversion elements, and a light barrier layer (52).Type: GrantFiled: September 16, 2010Date of Patent: December 3, 2013Assignee: Koninklijke Philips N.V.Inventors: Steven E. Cooke, Andreas Thon
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Publication number: 20130310681Abstract: In a combined system, a magnetic resonance (MR) scanner includes a magnet configured to generate a static magnetic field at least in a MR examination region from which MR data are acquired. Radiation detectors are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region. The radiation detectors include electron multiplier elements having a direction of electron acceleration arranged substantially parallel or anti-parallel with the static magnetic field. In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces disposed on opposite sides of a magnetic resonance examination region, and the radiation detectors include first and second arrays of radiation detectors disposed with the first and second spaced apart magnet pole pieces.Type: ApplicationFiled: July 25, 2013Publication date: November 21, 2013Applicant: KONINKLIJKE PHILIPS ELECTRONICS N. V.Inventors: Volkmar SCHULZ, Torsten SOLF, Johan OVERWEG, Andreas THON
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Patent number: 8519710Abstract: In a combined system, a magnetic resonance (MR) scanner includes a magnet configured to generate a static magnetic field at least in a MR examination region from which MR data are acquired. Radiation detectors are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region. The radiation detectors include electron multiplier elements having a direction of electron acceleration arranged substantially parallel or anti-parallel with the static magnetic field. In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces disposed on opposite sides of a magnetic resonance examination region, and the radiation detectors include first and second arrays of radiation detectors disposed with the first and second spaced apart magnet pole pieces.Type: GrantFiled: April 26, 2012Date of Patent: August 27, 2013Assignee: Koninklijke Philips N.V.Inventors: Volkmar Schulz, Torsten Solf, Johan Overweg, Andreas Thon
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Patent number: 8481948Abstract: A light transmitting element such as a scintillating element (50) or an optic fiber (50?) has side surfaces coated with a metamaterial (62) which has an index of refraction less than 1 and preferably close to zero to light transmitted in the light transmitting element. A photonic crystal (80) or metamaterial layer optically couples a light output face of the light transmitting element with a light sensitive element (52), such as a silicon photomultiplier (SiPM). A thin metal layer (64) blocks optical communication between adjacent scintillating elements (50) in a radiation detector (22), such as a radiation detector of a nuclear imaging system (10).Type: GrantFiled: February 9, 2010Date of Patent: July 9, 2013Assignee: Koninklijke Philips Electronics N.V.Inventors: Thomas Frach, Andreas Thon
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Publication number: 20130153776Abstract: The present invention relates to a pixellated detector with an enhanced structure to enable easy pixel identification even with high light output at crystal edges. A half-pixel shift between scintillator crystals (50) and detector pixels (12) enables the identification of a crystal (50) from four detector pixels (12) instead of nine pixels in case of optical crosstalk. Glass plates without any mechanical structuring may be used as a common substrate (60) for detectors and scintillators.Type: ApplicationFiled: August 18, 2011Publication date: June 20, 2013Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Herfried Karl Wieczorek, Andreas Thon