Patents by Inventor Andreas Vaupel

Andreas Vaupel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof
    Patent number: 7135486
    Abstract: This application relates to compounds of formula (I), wherein R1, R2, R3, and R4 are defined as recited in the claims, or a tautomer, salt, hydrate, or alkoxide thereof. A process for preparing such materials, pharmaceutical compositions containing them, and methods of treating a cardiovascular disorder by administering them to a patient are also disclosed and claimed.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: November 14, 2006
    Assignee: Bayer Aktiengeselischaft
    Inventors: Ulrich Rosentreter, Rolf Henning, Marcus Bauser, Thomas Krämer, Andrea Vaupel, Walter Hübsch, Klaus Dembowsky, Olga Salcher-Schraufstätter, Johannes-Peter Stasch, Thomas Krahn, Elisabeth Perzborn
  • Substituted 2-carba-3,5-dicyano-4-aryl-6-aminopyridines and the use of the same as selective ligands of the adenosine receptor
    Patent number: 7129255
    Abstract: This application relates to compounds of the formula wherein the groups R1–R6 are as defined in the specification and claims, and to a pharmaceutical composition containing the same, and to a method of using the same in treatment of cardiovascular disorders.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: October 31, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Rosentreter, Thomas Krämer, Andrea Vaupel, Walter Hübsch, Nicole Diedrichs, Thomas Krahn, Klaus Dembowsky, Johannes-Peter Stasch, Mitsuyuki Shimada
  • Biphenyl and biphenyl-analogous compounds as integrin antagonists
    Patent number: 7094911
    Abstract: The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophylaxis of cancer, arteriosclerosis, restenosis, osteolytic disorders such as osteoporosis and ophthalmic diseases. The compounds according to the invention have the formula (1) wherein R1, R2, U, V, A, B, W, R3, C and R4 have the meaning as defined in the claims.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: August 22, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Markus Albers, Klaus Urbahns, Andrea Vaupel, Michael Härter, Delf Schmidt, Beatrix Stelte-Ludwig, Christoph Gerdes, Elke Stahl, Jörg Keldenich, Ulf Brueggemeier, Klemens Lustig
  • Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines with adenosine receptor-binding activity and their use as cardiovascular preparations
    Patent number: 7078417
    Abstract: This application relates to pyridine derivatives having the general structure in which the several variables are as defined in the specification and claims, and to a process for preparing these compounds, a pharmacutical composition containing such compounds, and a method for using these materials for treatment of stable and unstable angina pectoris and atrial fibrillation.
    Type: Grant
    Filed: March 19, 2002
    Date of Patent: July 18, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Rosentreter, Thomas Krämer, Andrea Vaupel, Walter Hübsch, Nicole Diedrichs, Thomas Krahn, Klaus Dembowsky, Johannes-Peter Stasch, Mitsuyuki Shimada
  • Adenosine receptor selective modulators
    Publication number: 20060154969
    Abstract: The invention relates to the compounds of formula (I), to a method for producing the same and to the use thereof as medicaments.
    Type: Application
    Filed: February 28, 2002
    Publication date: July 13, 2006
    Inventors: Ulrich Rosentreter, Thomas Kramer, Andrea Vaupel, Walter Hubsch, Nicole Diedrichs, Thomas Krahn, Klaus Dembowsky, Johannes-Peter Stasch
  • Substituted 2-oxy-3,5-dicyano-4-aryl-6-aminopyridines and use thereof
    Publication number: 20050261502
    Abstract: The use of compounds of formula (I) as medicaments, novel compounds of formula (I) and a method for production thereof are disclosed. Compounds of formula (I) are effective as adenosine receptor ligands.
    Type: Application
    Filed: February 20, 2002
    Publication date: November 24, 2005
    Inventors: Ulrich Rosentreter, Thomas Kramer, Andrea Vaupel, Walter Hubsch, Nicole Diedrichs, Thomas Krahn, Klaus Dembowsky, Johannes-Peter Stasch
  • Tetrahydroisoquinoline derivatives
    Publication number: 20050234096
    Abstract: The invention relates to novel substituted tetrahydroisoquinoline derivatives, methods for the production thereof and the use thereof in medicaments, especially as potent PPAR-delta activating compounds for the prophylaxis and/or treatment of cardiovascular diseases, especially dislipidaemia, coronary heart disease and arteriosclerosis.
    Type: Application
    Filed: May 5, 2003
    Publication date: October 20, 2005
    Inventors: Hilmar Bischoff, Elke Dittrich-Wengenroth, Verena Vohringer, Heike Heckroth, Andrea Vaupel, Michael Woltering, Michael Otteneder
  • Acetic acid derivatives
    Publication number: 20050154061
    Abstract: The present invention relates to novel substituted acetic acid derivatives, to processes for their preparation and to their use in medicaments, in particular as potent PPAR-delta-activating compounds for the prophylaxis and/or treatment of cardiovascular disorders, in particular dyslipidaemias and coronary heart diseases.
    Type: Application
    Filed: October 9, 2002
    Publication date: July 14, 2005
    Applicant: Bayer Aktiengesellschaft
    Inventors: Hilmar Bischoff, Elke Dittrich-Wengenroth, Heike Heckroth, Andrea Vaupel, Michael Woltering, Stefan Weigand
  • Substituted 2,6-diamino-3,5-dicyano-4-aryl-pyridines and their use as adenosine receptor-selective ligands
    Publication number: 20040162427
    Abstract: The invention relates to the use of compounds of formula (I) as medicaments, to the novel compounds of formula (I) themselves, and to a method for the production thereof.
    Type: Application
    Filed: April 12, 2004
    Publication date: August 19, 2004
    Inventors: Ulrich Rosentreter, Thomas Krmer, Andrea Vaupel, Walter Hbsch, Nicole Diedrichs, Thomas Krahn, Klaus Dembowsky, Johannes Stasch
  • Substituted 2-carba-3,5-dicyano-4-aryl-6-aminopyridines and the use of the same as selective ligands of the adenosine receptor
    Publication number: 20040110946
    Abstract: The invention relates to compounds of formula (I), a method for the production thereof and the use of the same as pharmaceuticals.
    Type: Application
    Filed: January 7, 2004
    Publication date: June 10, 2004
    Inventors: Ulich Rosentreter, Thomas Kramer, Andrea Vaupel, Walter Hubsch, Nicole Diedrichs, Thomas Krahn, Klaus Dembowsky, Johannes-Peter Stasch, Mitsuyuki Shimada
  • Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines with adenosine receptor-binding activity and their use cardiovascular preparations
    Publication number: 20040102626
    Abstract: The invention relates to the compounds of formula (I), to a method for producing them and to their use as medicaments.
    Type: Application
    Filed: January 7, 2004
    Publication date: May 27, 2004
    Inventors: Ulrich Rosentreter, Thomas Kramer, Andrea Vaupel, Walter Hubsch, Nicole Diedrichs, Thomas Krahn, Klaus Dembowsky, Johannes Peter Stasch, Mitsuyuki Shimada
  • New biphenyl and biphenyl-analogous compounds as integrin antagonists
    Publication number: 20040030132
    Abstract: The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophylaxis of cancer, arteriosclerosis, restenosis, osteolytic disorders such as osteoporosis and ophthalmic diseases.
    Type: Application
    Filed: October 31, 2002
    Publication date: February 12, 2004
    Inventors: Markus Albers, Klaus Urbahns, Andrea Vaupel, Michael Harter, Delf Schmidt, Beatrix Stelte-Ludwig, Christoph Gerdes, Elke Stahl, Jorg Keldenich, Ulf Brueggemeier, Klemens Lustig
  • Biphenyl and biphenyl-analogous compounds as integrin antagonists
    Patent number: 6677360
    Abstract: The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophylaxis of cancer, arteriosclerosis, restenosis, osteolytic disorders such as osteoporosis and ophthalmic diseases. The compounds according to the invention have the formula (1) wherein R1, R2, U, V, A, B, W, R3, C and R4 have the meaning as defined in the claims.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: January 13, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Markus Albers, Klaus Urbahns, Andrea Vaupel, Michael Härter, Delf Schmidt, Beatrix Stelte-Ludwig, Christoph Gerdes, Elke Stahl, Jörg Keldenich, Ulf Brueggemeier, Klemens Lustig
  • Phenylserine derivatives as integrin antagonists
    Patent number: 6545029
    Abstract: The present invention relates to new phenylserine derivatives as integrin antagonists with a broad spectrum of action having, inter alia, antiosteoporotic, antirestenotic, anticarcinogenic and antiatherosclerotic activity. The present invention moreover relates to the preparation of these compounds and their use for the production of medicaments, and also medicaments comprising them.
    Type: Grant
    Filed: June 12, 2001
    Date of Patent: April 8, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventor: Andrea Vaupel
  • Phenylserine derivatives as integrin antagonists
    Publication number: 20020095050
    Abstract: The present invention relates to new phenylserine derivatives as integrin antagonists with a broad spectrum of action having, inter alia, antiosteoporotic, antirestenotic, anticarcinogenic and antiatherosclerotic activity. The present invention moreover relates to the preparation of these compounds and their use for the production of medicaments, and also medicaments comprising them.
    Type: Application
    Filed: June 12, 2001
    Publication date: July 18, 2002
    Inventor: Andrea Vaupel
  • Biphenyl and biphenyl-analogous compounds as integrin antagonists
    Patent number: 6420396
    Abstract: The present invention relates to 2-Mesitylsulfonylamino-3-{3′[(pyridinylamino)methyl][1,1-biphenyl]-4-yl}propanoic acid, pharmaceutical compositions thereof, their preparation, their use in the treatment of cancer, arteriosclerosis, restenosis, osteolytic disorders, ophthalmic disorders, and their use as integrin antagonists.
    Type: Grant
    Filed: December 15, 1999
    Date of Patent: July 16, 2002
    Assignee: Beiersdorf AG
    Inventors: Markus Albers, Klaus Urbahns, Andrea Vaupel, Michael Härter, Delf Schmidt, Beatrix Stelte-Ludwig, Christoph Gerdes, Elke Stahl, Jörg Keldenich, Ulf Brueggemeier, Klemens Lustig
  • Biphenyl and biphenyl-analogous compounds as integrin antagonists
    Publication number: 20020016461
    Abstract: The present invention relates to biphenyl and biphenyl-analogous compounds, their preparation and use as pharmaceutical compositions, as integrin antagonists and in particular for the production of pharmaceutical compositions for the treatment and prophylaxis of cancer, arteriosclerosis, restenosis, osteolytic disorders such as osteoporosis and ophthalmic diseases.
    Type: Application
    Filed: April 6, 2001
    Publication date: February 7, 2002
    Inventors: Markus Albers, Klaus Urbahns, Andrea Vaupel, Michael Harter, Delf Schmidt, Beatrix Stelte-Ludwig, Christoph Gerdes, Elke Stahl, Jorg Keldenich, Ulf Brueggemeier, Klemens Lustig