Abstract: Disclosed herein are methods of identifying a compound for treating or preventing an infection with an infectious microbe, such as a coronavirus, in a subject in need thereof. Also disclosed herein are compounds and compositions identified by said methods, and methods of use thereof.

Abstract: A method for detecting scratches and bumps applied to a vehicle uses an acceleration sensor. Signals of the sensor are analyzed and evaluated based on amplitude and frequency. Relationships between the amplitudes and frequencies provide a basis to classify a vehicle contact event as a bump or a scratch.

Abstract: A thin-film solar module with a substrate and a layer structure applied thereon that comprises a rear electrode layer, a front electrode layer, and an absorber layer arranged between the back electrode layer and the front electrode layer. Serially connected solar cells are formed in the layer structure by patterning zones, wherein each patterning zone comprises a first patterning line for subdividing at least the rear electrode layer, a second patterning line for subdividing at least the absorber layer, and at least one third patterning line for subdividing at least the front electrode layer. At least one patterning zone has one or more optically transparent zones in a zone region reduced by the first patterning line, which are in each case rear-electrode-layer-free, wherein the one or more optically transparent zones are implemented such that the rear electrode layer is continuous in the zone region.

Abstract: A method and a device are provided for homogeneously coating surfaces of 3D substrates in a vacuum chamber which has a sputtering source, such as a planar source or a tube or double-tube source, wherein individual substrates, with a curved substrate surface directed toward the sputtering source, are able to be moved past said source in a translational manner. The sputtering source is fastened to a chamber wall within a vacuum chamber so as to have two degrees of freedom such that the sputtering source is able to be set both in terms of its spacing to a surface to be coated of a substrate, which is moved past in front of said sputtering source in a translational manner, and with respect to the surface normal of the surface to be coated proceeding from a fixed point such that the surface normal deviation is 0° at all times.

Abstract: Triosephosphate isomerase deficiency (TPI Df) is a devastating childhood degenerative disease for which there are currently no treatments. Pathogenesis of this disease is driven by mutations that destabilize the TPI protein. A genome-wide RNAi screen in Drosophila to identify regulators of TPI stability is described. The screen identified 25 proteins that are critical to TPI stability, each of which has a human ortholog. Methods of promoting TPI protein stability and treating TPI Df in a subject by administering a therapeutically effective amount of an agent that inhibits expression or activity of one of the identified regulators are described. Also described is a method for the identification of agents capable of promoting stability of mutant TPI. Methods for treating a subject who has TPI Df by administering an agent that promotes stability of mutant TPI is also described.

Abstract: The disclosure relates to a method for training a classifier to determine a handheld machine tool device state, comprising the following steps:—providing a handheld machine tool; —providing at least one sensor; —operating the handheld machine tool continuously; —terminating the continuous operation, in particular in the event of damage occurring; —capturing sensor data during the continuous operation; —extracting features on the basis of the sensor data; —ascertaining at least two handheld machine tool device states on the basis of the extracted features.

Abstract: Configuration of a building. A method of configuring a site, the site comprising a plurality of devices (11-23), the plurality of devices (11-23) comprising a plurality of site controllers and a plurality of sensors and a plurality of appliances, the method comprising the steps of: selecting a first device (11-23) from the plurality of appliances and/or from the plurality of sensors; producing first descriptor data for the first device (11-23); selecting a second device (11-23) from the plurality of appliances and/or from the plurality of sensors; producing second descriptor data for the second device (11-23); loading data indicative of an ontology database (9), the ontology database comprising a set of rules; producing relationship data by applying one or more rules to the first and second descriptor data; selecting a third device (11-23) from among the controllers.

Abstract: The invention relates to a magnetic coupling element (100) with a magnetic bearing function. The magnetic coupling element (100) has a drive-side coupling magnet (109) arranged on a drive shaft (106), and also an output-side coupling magnet (115) arranged on an output shaft (112), the output-side coupling magnet (115) being magnetically coupled to the drive-side coupling magnet (109), and finally a bearing magnet ring (118) which is non-rotatably mounted with respect to the drive-side or output-side coupling magnet (109) or (115), a bearing magnet portion (133, 136) of the bearing magnet ring (118) having the same polarity as a coupling magnet portion (127, 130) opposite the bearing magnet portion (136).

Abstract: A self-propelled construction machine for milling a ground surface is provided with a machine frame, a working drum, and a transport conveyor with a discharge end from which worked-off milling material is dischargeable onto a point of impingement on a loading surface of a transport vehicle, wherein the transport conveyor is laterally slewable to a slewing angle about at least a first slewing axis. A controller is configured, during an initialization process, to specify a command variable within a coordinate system, the coordinate system being stored during the initialization process with its origin at a starting point associated with the machine. The controller is further configured during a working process, wherein the coordinate system is stationary, to automatically control the slewing angle corresponding to detected changes in position and/or orientation of the machine and relative to the command variable.

Abstract: A self-propelled construction machine for milling a ground surface is provided with a machine frame, a working drum, and a transport conveyor with a discharge end from which worked-off milling material is dischargeable onto a point of impingement on a loading surface of a transport vehicle, wherein the transport conveyor is laterally slewable to a slewing angle about at least a first slewing axis. A controller is configured, during an initialization process, to specify a command variable within a coordinate system independent of a position and/or orientation of the machine, the coordinate system being stored during the initialization process with its origin at a starting point associated with the machine. The controller is further configured during a working process, wherein the coordinate system is stationary, to automatically control the slewing angle corresponding to detected changes in position and/or orientation of the machine and relative to the command variable.

Abstract: In a self-propelled construction machine for working ground pavements comprising at least one machine frame, at least one height-adjustable milling drum for working the ground pavement in a working operation, driven by at least one drive unit, at least one control device for monitoring and controlling the milling depth of the milling drum and the speed of the construction machine, it is provided for the following features to be achieved: that a monitoring device detects an interruption of the working operation, and when detecting the interruption of the working operation emits a signal to interrupt the drive of the milling drum.

Abstract: A construction machine is provided with a control device having an operating panel with operating elements, which can assume numerous switching states/positions, a control and monitoring unit for controlling machine components via control signals signalling the switching state/position of associated operating elements, and a display/signal unit interacting with the control and monitoring unit. The control device provides first and second signal transmission paths for transmitting a first control signal signalling the switching state/position of a first operating element and a second control signal signalling the switching state/position of a second operating element, respectively. The control signals are checked for the existence of a plausibility criterion. If the plausibility criterion is not met, signal transmission over one or the other signal transmission path is deactivated, wherein the functionality of the relevant component is checked.

Abstract: The invention relates to a magnetic coupling element (100) with a magnetic bearing function. The magnetic coupling element (100) has a drive-side coupling magnet (109) arranged on a drive shaft (106), and also an output-side coupling magnet (115) arranged on an output shaft (112), the output-side coupling magnet (115) being magnetically coupled to the drive-side coupling magnet (109), and finally a bearing magnet ring (118) which is non-rotatably mounted with respect to the drive-side or output-side coupling magnet (109) or (115), a bearing magnet portion (133, 136) of the bearing magnet ring (118) having the same polarity as a coupling magnet portion (127, 130) opposite the bearing magnet portion (136).

Abstract: In a self-propelled construction machine for working ground pavements comprising at least one machine frame, at least one height-adjustable milling drum for working the ground pavement in a working operation, driven by at least one drive unit, at least one control device for monitoring and controlling the milling depth of the milling drum and the speed of the construction machine, it is provided for the following features to be achieved: that a monitoring device detects an interruption of the working operation, and when detecting the interruption of the working operation emits a signal to interrupt the drive of the milling drum.

Abstract: In a self-propelled construction machine comprising a machine frame with a longitudinal axis, a controller for the travelling and milling operation, a height-adjustable working drum, and a slewable transport conveyor: that the control system, at least as a function of a virtual trajectory for positioning the transport conveyor which is freely specifiable in a stationary coordinate system that is independent of the position and alignment of the machine frame, controls, by means of open-loop control or closed-loop control, at least the slewing angle of the transport conveyor automatically in such a fashion that a reference point of the transport conveyor always remains on the specified trajectory in the case of a change in position of the machine frame within the coordinate system.

Abstract: A method for detecting scratches and bumps applied to a vehicle uses an acceleration sensor. Signals of the sensor are analyzed and evaluated based on amplitude and frequency. Relationships between the amplitudes and frequencies provide a basis to classify a vehicle contact event as a bump or a scratch.

Abstract: The invention relates to a magnetic coupling element (100) with a magnetic bearing function. The magnetic coupling element (100) has a drive-side coupling magnet (109) arranged on a drive shaft (106), and also an output-side coupling magnet (115) arranged on an output shaft (112), the output-side coupling magnet (115) being magnetically coupled to the drive-side coupling magnet (109), and finally a bearing magnet ring (118) which is non-rotatably mounted with respect to the drive-side or output-side coupling magnet (109) or (115), a bearing magnet portion (133, 136) of the bearing magnet ring (118) having the same polarity as a coupling magnet portion (127, 130) opposite the bearing magnet portion (136).

Abstract: A method for detecting scratches and bumps applied to a vehicle uses an acceleration sensor. Signals of the sensor are analyzed and evaluated based on duration and frequency.

Abstract: The invention relates to a milling machine, in particular a road milling machine, a stabiliser, a recycler or a surface miner, comprising a drive means which is configured such that the milling machine performs translatory and/or rotatory movements on the ground, and a working means which is configured such that the ground is machined. The invention also relates to a method for operating a milling machine of this type. The milling machine according to the invention has a control unit 15 to input drive parameters and work parameters. The control unit 15 is distinguished by a selection unit 15C to select an operating mode from a plurality of operating modes. The control and processing unit 20 has a memory 20A which stores at least one predetermined drive parameter which is assigned to the operating mode, and/or at least one predetermined work parameter which is assigned to the operating mode, for each operating mode of the plurality of operating modes.

Abstract: The invention relates to a method for producing components of a tilting-pad bearing (10; 10a), wherein: the tilting-pad bearing (10; 10a) has an outer ring (12; 12a) and multiple tilting pads (18; 18a) preferably arranged at regular angular intervals about a longitudinal axis (3; 46) of the outer ring (12; 12a); the tilting pads (18; 8a) are pivotably mounted with an outer surface (20; 20a) about a pitch line (26; 26a) on an inner surface (16; 16a) of the outer ring (12; 12a); and a blank (30; 30a) in the form a cylinder portion (14) having a constant wall thickness is used to produce the tilting pads (18) from a tilting pad ring (42) or to produce the outer ring (12a).