Patents by Inventor Andreas Waechtler

Andreas Waechtler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10273213
    Abstract: The present invention provides methods of preparing Praziquantel, in particular (R)-Praziquantel and analogues thereof in a stereoselective manner. One method involves asymmetric hydrogenation of the following intermediate compound and subsequent cyclization.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: April 30, 2019
    Assignee: Merck Patent GmbH
    Inventors: Luc Eberhardt, Andreas Waechtler, David Maillard, Stefan Lehmann
  • Patent number: 10160758
    Abstract: The present invention relates to a method for the racemization of enantiomerically pure or enantiomerically enriched Praziquantel under basic conditions and a method for the production of (R)-Praziquantel in enantiopure or enantiomerically enriched form, which comprises the racemization method.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: December 25, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Andreas Waechtler, Hadia Saleh-Kassim, Christian Jasper, Joern Kolb, David Maillard
  • Publication number: 20180251428
    Abstract: The present invention provides methods of preparing Praziquantel, in particular (R)-Praziquantel and analogues thereof in a stereoselective manner. One method involves asymmetric hydrogenation of the following intermediate compound and subsequent cyclization.
    Type: Application
    Filed: August 10, 2016
    Publication date: September 6, 2018
    Applicant: Merck Patent GmbH
    Inventors: Luc EBERHARDT, Andreas WAECHTLER, David MAILLARD, Stefan LEHMANN
  • Publication number: 20180155339
    Abstract: The present invention relates to a method for the racemization of enantiomerically pure or enantiomerically enriched Praziquantel under basic conditions and a method for the production of (R)-Praziquantel in enantiopure or enantiomerically enriched form, which comprises the racemization method.
    Type: Application
    Filed: November 17, 2015
    Publication date: June 7, 2018
    Applicant: MERCK PATENT GMBH
    Inventors: Andreas WAECHTLER, Hadia SALEH-KASSIM, Christian JASPER, Joern KOLB, David MAILLARD
  • Patent number: 9932337
    Abstract: The present invention relates to methods for the production of enantiopure or enantioenriched Praziquantel precursors and to methods for the production of enantiopure or enantioenriched Praziquantel comprising the methods for the production of the Praziquantel precursors. The present invention further relates to compounds or intermediates useful in such methods.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: April 3, 2018
    Assignee: Merck Patent GmbH
    Inventors: David Maillard, Andreas Waechtler, Jeremy Maurin, Ewgenij Wakaresko, Christian Jasper
  • Publication number: 20170320873
    Abstract: The present invention relates to methods for the production of enantiopure or enantioenriched Praziquantel precursors and to methods for the production of enantiopure or enantioenriched Praziquantel comprising the methods for the production of the Praziquantel precursors. The present invention further relates to compounds or intermediates useful in such methods.
    Type: Application
    Filed: November 19, 2015
    Publication date: November 9, 2017
    Applicant: Merck Patent GmbH
    Inventors: David MAILLARD, Andreas WAECHTLER, Jeremy MAURIN, Ewgenij WAKARESKO, Christian JASPER
  • Patent number: 8877092
    Abstract: The invention relates to a liquid-crystalline medium which comprises at least one compound of the formula I, in which R1, R1*, ring A have the meanings indicated in claim 1, and to the use thereof for an active-matrix display, in particular based on the VA, PSA, PS-VA, PALC, FFS or IPS effect.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: November 4, 2014
    Assignee: MERCK PATENT GmbH
    Inventors: Melanie Klasen-Memmer, Volker Reiffenrath, Konstantin Schneider, Andreas Waechtler, Elvira Montenegro
  • Publication number: 20120326084
    Abstract: The invention relates to a liquid-crystalline medium which comprises at least one compound of the formula I, in which R1, R1*, ring A have the meanings indicated in Claim 1, and to the use thereof for an active-matrix display, in particular based on the VA, PSA, PS-VA, PALC, FFS or IPS effect.
    Type: Application
    Filed: February 10, 2011
    Publication date: December 27, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Melanie Klasen-Memmer, Volker Reiffenrath, Konstantin Schneider, Andreas Waechtler, Elvira Montenegro
  • Patent number: 6677002
    Abstract: Novel phenylcyclohexanes of the formula I: in which n is 0 to 7, Q1 and Q2 are H, or one of these radicals is alternatively CH3, r is 0, 1, 2, 3, 4 or 5, A is trans-1,4-cyclohexylene, 1,4-phenylene, 3-fluoro-1,4-phenylene or a single bond, X is F, Cl, —CF3, —CN, —OCF3 or —OCHF2, and Y and Z are each, independently of one another, H or F, with the proviso that, in the case where A is a single bond, Q1═Q2═H and simultaneously X═CN, Y and/or Z are F.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: January 13, 2004
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Andreas Wächtler, Reinhard Hittich, Eike Poetsch, Herbert Plach, David Coates, Bernhard Rieger, Joachim Krause
  • Patent number: 6353125
    Abstract: Described are bis(perfluoro-n-alkane-sulfonate) compounds, methods for preparing these compounds and use of these compounds, for example as starting materials for the synthesis of chiral and phosphine ligands for transition metal catalysts.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: March 5, 2002
    Assignee: Merck Patent GmbH
    Inventors: Andreas Wächtler, Karl-Heinz Derwenskus, Andreas Meudt
  • Patent number: 6284154
    Abstract: Novel phenylcyclohexanes of the formula I in which n is 0 to 7, Q1 and Q2 are H, or one of these radicals is alternatively CH3, r is 0, 1, 2, 3, 4 or 5, A is trans-1,4-cyclohexylene, 1,4-phenylene, 3-fluoro-1,4-phenylene or a single bond, X is F, Cl, —CF3, —CN, —OCF3 or —OCHF2, and Y and Z are each, independently of one another, H or F, with the proviso that, in the case where A is a single bond, Q1═Q2═H and simultaneously X═CN, Y and/or Z are F.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 4, 2001
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Andreas Wächtler, Reinhard Hittich, Eike Poetsch, Herbert Plach, David Coates, Bernhard Rieger, Joachim Krause