Abstract: A stator for an electric machine includes a stator body having a large number of stator grooves, wherein, in each stator groove in the radial direction, a plurality of conductors are arranged one above the other. A plurality of spacing elements are configured to maintain a predetermined spacing between the conductors and a spacing of the respective conductors from a groove wall of the stator body, wherein, within the stator groove, respective cooling channels, which are at least partially delimited by the respective conductors, are kept free, whereby a cooling fluid can flow directly along the conductors, wherein each of the conductors has in the cross section thereof an angular form, and each of the corners of the angular form is supported by a respective spacing element against an additional conductor and/or the groove wall.

Abstract: A method of producing a lipid-encapsulated RNA nanoparticle, comprising the steps a) flowing an aqueous solution comprising an RNA through a 1st tube having an inner diameter (ID) of between about 0.1? and 0.132?; b) flowing an ethanol solution comprising lipids through a 2nd tube having an ID of between about 0.005? and 0.02? at one third the flow rate of the aqueous solution through the 1st tube, wherein the lipids comprise a cationic lipid; and c) mixing the ethanol solution with the aqueous solution by flowing the ethanol solution and the aqueous solution into a mixing module consisting of the 2nd tube perpendicularly joined to the 1st tube; wherein the mixing produces an output solution flowing in the 1st tube comprising a turbulent flow of the RNA and the lipids in between about 10% to 75% ethanol v/v, and wherein the lipid-encapsulated RNA nanoparticles have a bilayer structure.

Abstract: The invention relates to a method for the operational analysis of an engine and/or for calibrating a controller of the engine, in particular an internal combustion engine, wherein run-up occurs of test points defined by values of a plurality of predetermined operating parameters and selected from a multidimensional test space using a statistical experiment design, whereby at least one operating parameter is in each case changed from one test point to the next test point in a plurality of steps in the run-up of the test points, wherein operational measurements are performed at measurement points resulting from a respective increment and at the actual test points, whereby measurement data from the operational measurements for the analysis and calibration of the controller are output and continuously stored, as well as a corresponding system.

Abstract: A stator for an electric machine of a motor vehicle includes with a laminated core in which at least one cooling channel runs, through which a cooling fluid for cooling the stator can flow, and at least one winding which is held on the laminated core and has a winding head. At least one ring is provided which adjoins a laminated core at least partially in the axial direction of the stator, has at least one guide channel which is connected fluidically to the cooling channel and through which the cooling fluid from the cooling channel can flow as a result, which guide channel has at least one outlet opening which is directed towards the winding head and via which the cooling fluid which flows through the cooling channel can be discharged from the ring and can be sprayed against the winding head.

Abstract: A processor unit for multiply and accumulate (“MAC”) operations is provided. The present invention may include the processor unit having a plurality of MAC units for performing a set of MAC operations. The present invention may include each MAC unit having an execution unit and a one-write one-read (“1W/1R”) register file, where the 1W/1R register file may have at least one accumulator. The present invention may include the execution unit of each MAC unit being configured to perform a subset of MAC operations by computing a product of a set of values received from another register file of the processor unit and adding the computed product to the at least one accumulator. The present invention may include each MAC unit being configured to perform the respective subset of MAC operations in a single clock cycle.

Abstract: A method for honing a rotationally symmetric, non-cylindrical bore includes the steps of limiting the stroke of a honing tool between upper and lower reversal points, continoulsy detecting the actual diameter of the bore at all points along its length between the upper and lower reversal points, continuously comparing the actual diameter of the bore to a specified target diameters for at least one of the upper or lower reversal points, continuously limiting the stroke to regions of the bore in which the actual diameter is smaller than the target diameter, continuously limiting the stroke to regions of the bore in which the actual diameter is smaller than the target diameter, and reducing the stroke of the honing tool step-by-step based on the detected actual values of the diameter of the bore, so that it only the regions of the bore that are machined in which the actual diameter of the bore is smaller than the target diameter corresponding to the detected actual values of the diameter.

Abstract: According to various embodiments of the invention, a heat exchanger can have at least one duct for conveying a coolant, wherein the at least one duct has a first section and a second section, the first section being arranged in the at least one duct upstream relative to the second section, in relation to a flow direction of the coolant, the second section having a cross section area that is larger than a cross section area of the first section, such that a sublimation of the coolant in the second section is made possible.

Abstract: The present disclosure provides methods and intermediates for making Compound A or a pharmaceutical salt thereof, and/or a solvate of, which are useful as methods and intermediates for producing compounds for treating diseases and conditions related to mutant KIT and PDGFRA.

Abstract: A method of producing a lipid-encapsulated RNA nanoparticle, comprising the steps a) flowing an aqueous solution comprising an RNA through a 1st tube having an inner diameter (ID) of between about 0.1? and 0.132?; b) flowing an ethanol solution comprising lipids through a 2nd tube having an ID of between about 0.005? and 0.02? at one third the flow rate of the aqueous solution through the 1st tube, wherein the lipids comprise a cationic lipid; and c) mixing the ethanol solution with the aqueous solution by flowing the ethanol solution and the aqueous solution into a mixing module consisting of the 2nd tube perpendicularly joined to the 1st tube; wherein the mixing produces an output solution flowing in the 1st tube comprising a turbulent flow of the RNA and the lipids in between about 10% to 75% ethanol v/v, and wherein the lipid-encapsulated RNA nanoparticles have a bilayer structure.

Abstract: A computer system, processor, and method for processing information is disclosed that includes at least one computer processor; a main register file associated with the at least one processor, the main register file having a plurality of entries for storing data, one or more write ports to write data to the main register file entries, and one or more read ports to read data from the main register file entries; one or more execution units including a dense math execution unit; and at least one accumulator register file having a plurality of entries for storing data. The results of the dense math execution unit in an aspect are written to the accumulator register file, preferably to the same accumulator register file entry multiple times, and the data from the accumulator register file is written to the main register file.

Abstract: An exhaust muffler for an exhaust system of an internal combustion engine includes a muffler housing (12) with an outer shell (14) enclosing a muffler interior (22), through which exhaust gas can flow. An inner shell (54) is arranged in the muffler interior (22) and covers the outer shell (14) in at least some areas on an inner side (52) facing the muffler interior (22).

Abstract: A computer system, processor, and method for processing information is disclosed that includes at least one computer processor; a main register file associated with the at least one processor, the main register file having a plurality of entries for storing data, one or more write ports to write data to the main register file entries, and one or more read ports to read data from the main register file entries; one or more execution units including a dense math execution unit; and at least one accumulator register file having a plurality of entries for storing data. The results of the dense math execution unit in an aspect are written to the accumulator register file, preferably to the same accumulator register file entry multiple times, and the data from the accumulator register file is written to the main register file.

Abstract: Aspects include a compute array of a processor with mixed-precision numerical linear algebra support. A first precision and a first shape of a first input matrix and a second precision and a second shape of a second input matrix to the compute array are determined. A plurality of linear algebra operations is repeated in parallel within the compute array to update a result matrix in an accumulator register based on the first input matrix, the second input matrix, and a number of rank updates of the result matrix to store in the accumulator register.

Abstract: A stacked-plate heat exchanger may include a plurality of stacked plates. The plurality of stacked plates may include a plurality of first stacked plates and a plurality of second stacked plates stacked alternately one on top of another. Pairs of adjacent stacked plates may each delimit one of a first cavity for the passage of a first fluid and a second cavity for the passage of a second fluid in an alternating manner. The heat exchanger may also include a support structure that may support the plurality of stacked plates in an edge region to stabilize the second cavity. The plurality of stacked plates may each include a first opening and at least two second openings arranged around the first opening. The heat exchanger may also include a plurality of webs each arranged between two adjacent second openings. The plurality of webs may form the support structure.

Abstract: The present invention relates to a polynucleotide comprising a Nuclear factor of activated T-cells (NFAT) binding site sequence and a reverse complement of said NFAT binding site sequence separated by a spacer sequence, to said polynucleotide for use in treating and/or preventing disease, and to viral particles, compositions, and uses related thereto. The present invention further relates to a polynucleotide comprising a Nuclear factor of activated T-cells (NFAT) binding site sequence and a reverse complement of said NFAT binding site sequence for use in treating and/or preventing an NFAT-mediated disease.

Abstract: A system and method for avoiding write back collisions. The system receives a plurality of instructions at a pipeline queue. Next an issue queue determines a number of cycles for each instruction of the plurality of instructions. The issue queue further determines if a collision will occur between at least two of the instructions. Additionally, the system determines in response to a collision between at least two of the instructions, a number of cycles to delay at least one of the at least two instructions. The instructions are then executed. The system then places the results of the instruction for instructions that had a calculated delay in a result buffer for the determined number of cycles of delay. After the determined number of cycles of delay, the system sends the results to a results mux. Once received at the results mux the results are written back to the register file.

Abstract: A consumables holder assembly for a plasma arc torch having a torch head, the consumables holder assembly comprising a main body, a shielding cup which engages to the main body, a connection means which engages the main body to the torch head and consumable components including an electrode, a nozzle, a plasma gas distributor, a shielding gas distributor which are all positioned inside the shielding cup, wherein that the consumable holder assembly can be detached from the torch head together with the consumable components and the shielding cup as one unit, wherein the connection means comprises a mechanical attachment mechanism which is engageable with the torch head.

Abstract: A consumables holder assembly for a plasma arc torch having a torch head, the consumables holder assembly comprising a main body, a shielding cup which engages to the main body, a connection means which engages the main body to the torch head, wherein the consumable components including an electrode, a nozzle, a plasma gas distributor, a shielding gas distributor which are all positioned inside the shielding cup, wherein the consumable holder assembly can be detached from the torch head together with the consumable components and the shielding cup as one unit, wherein the nozzle comprises two focus gas passageways which lead a focus gas out of the nozzle through at least two focus holes, wherein external visual features are provided on both connection means and the torch head which are aligned to each other showing the location of the focus holes.

Abstract: The invention relates to a method for the operational analysis of an engine and/or for calibrating a controller of the engine, in particular an internal combustion engine, wherein run-up occurs of test points defined by values of a plurality of predetermined operating parameters and selected from a multidimensional test space using a statistical experiment design, whereby at least one operating parameter is in each case changed from one test point to the next test point in a plurality of steps in the run-up of the test points, wherein operational measurements are performed at measurement points resulting from a respective increment and at the actual test points, whereby measurement data from the operational measurements for the analysis and calibration of the controller are output and continuously stored, as well as a corresponding system.

Abstract: A method for operating a communications system, in particular a communications system based on software-defined networking, which has at least one network infrastructure component, in particular an SDN switch, and at least one communications device, the network infrastructure component being developed for forwarding data to and/or from the at least one communications device. The method includes the following steps: allocating the communications device to at least one security zone; specifying at least one forwarding rule for forwarding data by the network infrastructure component to and/or from the communications device, the specification of the forwarding rule taking place under consideration of the security zone.