Abstract: A method for starting-up a device with an embedded multimedia card (eMMC) is provided. The method comprises providing power to the device, putting the eMMC in a Fast-Boot modus, reading a bootloader from the eMMC into a RAM of the device, starting the bootloader in a CPU of the device, terminating the Fast-Boot modus, resetting the eMMC, putting the eMMC in the Fast-Boot modus initializing hardware by the bootloader, while reading an operating system into the RAM using DMA, and starting the operating system from the RAM by the bootloader is provided. A device comprising an embedded eMMC is also disclosed.

Abstract: The present invention relates to a pharmaceutical combination comprising a KRAS G12C inhibitor and one or more therapeutic agents which is selected from an agent targeting the MARK pathway or an agent targeting parallel pathways; and pharmaceutical compositions comprising the same. The invention also relates to KRAS G12C inhibitors alone or said combinations for use in methods of treating a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutant.

Abstract: It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.

Abstract: The invention provided herein provides dosage and dosage regimens for N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine (Compound (1)), or a pharmaceutically acceptable salt thereof, Compound (1) for the treatment of PRC2-mediated diseases or disorders. In addition, the invention provides using such dosage and dosage regimens in methods for treating PRC2-mediated diseases or disorders.

Abstract: A method for starting-up a device with an embedded multimedia card (eMMC) is provided. The method comprises providing power to the device, putting the eMMC in a Fast-Boot modus, reading a bootloader from the eMMC into a RAM of the device, starting the bootloader in a CPU of the device, terminating the Fast-Boot modus, resetting the eMMC, putting the eMMC in the Fast-Boot modus initializing hardware by the bootloader, while reading an operating system into the RAM using DMA, and starting the operating system from the RAM by the bootloader is provided. A device comprising an embedded eMMC is also disclosed.

Abstract: The invention relates to a method for producing an indexable insert comprising the following steps: a) providing a starting material for use in an additive manufacturing method in several layers of material; and b) bonding each layer of the starting material in the form of an indexable insert.

Abstract: The present invention relates to a pharmaceutical combination comprising an FGFR4 inhibitor and a bile acid sequestrant, to the use of the pharmaceutical combination in the treatment of cancer, to the use of a bile acid sequestrant to reduce or mitigate side-effects associated with FGFR4 inhibition therapy.

Abstract: A rotary drive device has a fluid-actuated rotary drive with a drive housing and a drive unit which is rotative relative thereto. The drive unit includes a drive shaft and a pivot piston, non-rotatably arranged thereon, separating two drive chambers from one another. For controlling the fluid-actuated rotary drive, a control valve arrangement including at least one electrically actuatable control valve is provided, which is attached to the drive housing and in this way is combined with the rotary drive to form a drive assembly that can be handled as a single unit. Furthermore, a robot arm is proposed, which has the rotary drive device as an arm joint connecting two arm members.

Abstract: The present invention relates to a pharmaceutical combination comprising an FGFR4 inhibitor and a bile acid sequestrant, to the use of the pharmaceutical combination in the treatment of cancer, to the use of a bile acid sequestrant to reduce or mitigate side-effects associated with FGFR4 inhibition therapy.

Abstract: The present invention relates to therapeutic uses of compounds of formula (I) or a pharmaceutically acceptable salt thereof

Abstract: A rotary drive device has a fluid-actuated rotary drive with a drive housing and a drive unit which is rotative relative thereto. The drive unit includes a drive shaft and a pivot piston, non-rotatably arranged thereon, separating two drive chambers from one another. For controlling the fluid-actuated rotary drive, a control valve arrangement including at least one electrically actuatable control valve is provided, which is attached to the drive housing and in this way is combined with the rotary drive to form a drive assembly that can be handled as a single unit. Furthermore, a robot arm is proposed, which has the rotary drive device as an arm joint connecting two arm members.

Abstract: The present invention relates to therapeutic uses of compounds of formula (I) or a pharmaceutically acceptable salt thereof

Abstract: A pneumatic brake booster in which, for improving the sealing and simplifying the assembly of sealing elements, it is proposed that the booster housing in the bearing region of at least one sealing element has a metal coating having a surface roughness Ra>1.2.

Abstract: A pneumatic brake booster in which, for improving the sealing and simplifying the assembly of sealing elements, it is proposed that the booster housing in the bearing region of at least one sealing element has a metal coating having a surface roughness Ra>1.2.

Abstract: The present invention relates to therapeutic uses of compounds of formula (I) or a pharmaceutically acceptable salt thereof

Abstract: A tandem-type pneumatic brake booster, in particular for hydraulic vehicle brake systems, having a housing comprising a first and a second housing half shell, the interior of which is divided with the aid of a partition into a front and a rear booster chamber, wherein the partition has a centrally arranged, circular cavity, through which a control housing or a cylindrical control housing extension extends, and the partition rests sealingly against the control housing or the control housing extension by a sealing element, having a first and a second movable wall, which respectively subdivide the front and the rear booster chamber into a first low-pressure chamber and a first working chamber and into a second low-pressure chamber and a second working chamber, having at least one connecting conduit between the first working chamber and the second working chamber in order to equalize the pressure between said two working chambers.

Abstract: A method for detection of wind power installations using a radar installation is provided. The method involves transmitting a number N of predetermined sequences of modulated transmission pulses at a predetermined pulse repetition frequency successively in time and receiving and processing transmission pulses reflected by an object to determine whether the object is a wind power installation.

Abstract: Provided is a vehicle seat which is positionable between a use and not-it-use position convenient for increased storage space and access to rearward areas of the vehicle. The vehicle seat includes a seat part and a backrest. The seat part is pivotably coupled to the vehicle floor at one end so that that the seat part may be moved frontward with respect to the vehicle. A transmission link is provided, coupled to the backrest and the seat part so that the backrest pivots into the not-in-use position as the seat part is moved into its not-in-use position.

Abstract: An analytical system and method that enables more efficient transport of movable devices (22) among stations (24, 25, 26). According to one aspect of the invention, the system and method permit operational timesharing of a transport mechanism (34) for the movable devices. According to another aspect of the invention, control of the transport mechanism is effected on an event-driven basis. The invention has particular application to an adaptive, motion and fluids system for automating the sample handling/management process associated with analytical processes and especially bioanalytical processes such as introducing samples into LC and HPLC systems.

Abstract: The present invention is directed to a process for preparing [1S-[1?,2?,3?(1S*,2R*),5?]]-3-[7-[2-(3,4-difluorophenyl)-cyclopropylamino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol and to intermediates useful in the process.