Abstract: Systems, devices and method for laser Doppler-based fluid flow analysis. A Laser Doppler Velocimetry (LDV) technique may be used to analyze fluid flows in various contexts, such as blood flow in mechanical circulatory support (MCS) systems, and in other applications. Fluid velocity and volumetric flow may be measured. A laser source, optical fiber, and/or a photodiode may be used. Some embodiments may assess particulate parameters such as hemoglobin concentration in blood, reduce spectral noise via flow disturbance, reduce spectral noise using light of particular wavelength ranges, reduce noise via data analysis and signal processing techniques, and/or determine flow rate based on a non-linear relationship between a first weighted moment and the fluid flow.