Abstract: The invention relates to nucleases with improved properties such as enzymatic activity at high temperature, at low temperature, and/or high salt concentration. The invention also relates to methods for hydrolyzing polynucleotide substrates using the nucleases at high temperatures, at low temperature, or at high salt concentration. The invention further relates to uses of the nucleases for hydrolyzing polynucleotides in the manufacture of biopharmaceuticals, pharmaceutical compositions, vaccines, or viral vectors. Furthermore, the invention relates to kits comprising the nucleases.

Abstract: Embossing unit comprising a fixed structure (1) and a mobile structure (2) configured to be moved to and from the fixed structure (1), a first embossing assembly (LA), a second embossing assembly (UA) and a gluing assembly (GA), wherein the first embossing assembly (LA) comprises a first engraved steel roller (3) and a respective rubber counter-roller (4), wherein the second embossing assembly (UA) comprises a second steel engraved roller (5) and a respective rubber counter-roller (6), and wherein the gluing assembly (GA) is mounted on the mobile structure (2). The first embossing assembly (LA) and the engraved roller (5) of the second embossing assembly (UA) are mounted on the fixed structure (1) while the rubber counter-roller (6) of the second embossing assembly (UA) is mounted on the mobile structure above the gluing unit (GA).

Abstract: A vehicle floor sheet metal arrangement with a vehicle floor sheet metal as a component of a motor vehicle body, which has a flat floor region and a deformation on two opposite longitudinal sides and two opposite end sides, such that a vehicle floor sheet metal is formed that is arranged between two sills. In the flat floor region, at least one downward-facing molded recess is formed in the vertical direction (Z) of the motor vehicle, and the vehicle floor sheet metal is manufactured in one piece in a single press stroke, with regions of mutually different wall thickness and/or mutually different tensile strength Rm.

Abstract: Systems, computer program products, and methods are described herein for combinatorial data outlier detection via database query statement generation. A table comprising rows and columns is received, wherein each column comprises records and a corresponding data element. A datatype to be assigned to each data element is determined, based on each column and using a first machine learning model. Conditions are generated for columns corresponding to each data element. The conditions are combined into a predetermined number of condition combinations, wherein the condition combinations comprise combinatorial sequencing of the conditions. A query statement is generated for each of the condition combinations. The table in queried with each query statement to determine query results. A data element quantity and a record quantity in the query results are determined for each query statement.

Abstract: An air-moving device may include an aerodynamic rotor in the form of a bladed disk. The aerodynamic rotor may include a physical geometry that constrains a noise level of the air-moving device during operation. The air-moving device may be a leaf blower.

Abstract: Disclosed are novel conjugates and processes for the preparation thereof.

Abstract: A method and a system for generating synthetic time series data that is subject to various types of constraints are provided. The method includes: receiving first information that relates to a sample of a historical time series and second information that relates to constraints; obtaining a set of synthetic time series based on the first information and the second information; calculating a set of distances of respective differences between the historical time series and each of the set of synthetic time series; and selecting, from among the set, a first synthetic time series for which a corresponding distance is a maximum. The set of synthetic time series may be obtained by using a Sequential Least Squares Programming algorithm or by using a diffusion model that is trained according to a defined protocol.

Abstract: The present disclosure relates to a rear seat plate of a motor vehicle body, including a rear part of a floor plate and a rear seat support, wherein floor plate and rear seat support are vertically offset in relation to one another in the motor vehicle vertical direction (Z), and a tunnel section is optionally formed in the floor plate, and that floor plate and rear seat support are integrally formed via a connecting section as a sheet-metal formed component, in one press stroke, characterized in that a reinforcing structure is formed, and that different strengths and/or different wall thicknesses from one another are formed in different areas.

Abstract: An active learning system can analyze a dataset of users with self-reported symptoms and associated data from wearable devices to train a baseline machine learning model to predict symptoms of a chronic health condition based on wearable device data. For example, symptoms can be predicted in terms of lost physical activity, increased sleep requirements, and changes in resting heart rate. Using the baseline model, the active learning system can train and refine individual user-specific models to predict the onset of chronic health condition symptoms over time. These models can be used to predict symptoms for inclusion in a log of symptoms for the target user (which may be used by a healthcare provider to personalize treatment for the target user) or to provide interventions to the user (for example, warning of a predicted severe symptom day). In some implementations individual chronic health condition models are maintained and updated using active learning techniques.

Abstract: The present disclosure relates to a reality capture device for generating a digital three-dimensional representation of an environment, particularly for surveying and/or for detecting an object within an infrastructure. One aspect relates to a mobile reality capture device configured to be carried and moved by a mobile carrier, particularly a person or a robot or a vehicle, and to be moved during a measuring process for generating a digital representation of an environment. The mobile reality capture device has a localization unit, particularly comprising an inertial measurement unit (IMU), wherein the localization unit is configured for generating localization data for determining a trajectory of the mobile reality capture device.

Abstract: A computer-implemented method for behavior planning of a vehicle, a processing device, and a vehicle control device.

Abstract: A drone is disclosed having a low acoustic signature. The drone includes a fuselage, a main inboard wing attached to the fuselage, a pylon located towards an aft end of the fuselage and having an end that is higher than the main inboard wing, and a propulsor connected to the pylon and situated above the fuselage. The drone includes a plurality of booms connected to the main inboard wing and a plurality of horizontal tails attached to the plurality of booms. The horizontal tails have an outboard tail arrangement and are tiltable.

Abstract: A self-propelled agricultural working machine. The self-propelled agricultural working machine includes working units for collecting, processing and forwarding harvested material of a crop, a drive motor for driving the working units and propelling the self-propelled agricultural work machine at a travel speed, a camera device for capturing a digital image of the crop. A processor determines the available proportion of the harvested material based on the digital image and automatically adjusts the self-propelled agricultural work machine based thereon, including automatically adjusting the working units and/or the travel speed.

Abstract: According to an embodiment, a component for attachment to an article includes an upper component that is made of a thermoplastic material having a first melting temperature and a flange member that is molded onto the upper component and made of a thermoplastic elastomer material having a second melting temperature that is lower than the first melting temperature of the upper component. The flange member extends laterally from a bottom end of the upper component so that a bottom surface of the flange member is flush with or positioned axially below a bottom surface of the upper component. The melting temperature of the thermoplastic elastomer material enables the flange member to be directly coupled to the article via heat welding and the like without substantially affecting the upper component.

Abstract: Systems, methods, and apparatuses for automatically tuning computational probe threshold values in a containerized computing environment are provided herein. An example method comprises identifying a computational container environment that is operating outside of at least one predefined window of values of at least one performance metric, measuring the at least one performance metric, automatically adjusting at least one parameter value of a probe based upon the at least one performance metric, and iterating the measuring and adjusting until the computational container environment is operating within the at least one predefined window of values.

Abstract: A modular bioreactor system is provided including a platform having a seat to receive a modular tissue chamber, and one or more platform interfacial members; and a releasable modular tissue chamber including a bottom surface, an open top, and sidewalls defining a well therein, the releasable modular tissue chamber configured to be received by the seat of the platform, the tissue chamber further including an interfacial member configured to releasably connect the modular tissue chamber to the platform, wherein a tissue chamber contains human bone marrow (engineered using iPS cell derived osteoblasts, osteoclasts, endothelial cells, supporting mesenchymal cells, and hematopoietic cells in bone matrix) infused by primary leukemia cells

Abstract: An implantable electrode device is provided comprising a first layer and a second layer, the second layer being on top of the first layer and including at least one electrode contact. The at least one electrode contact is exposable to a nerve of a nervous tissue of a human or of an animal. A connecting means electrically connects the electrode contact, where the connecting means is made up of at least one conducting wire, and the conducting wire is arranged within the first layer and is fixed to the electrode contact.

Abstract: The present invention relates to a calcined shaped alumina and to a method of preparing a calcined shaped alumina. The method comprises that the alumina in the alumina suspension is hydrothermally aged to have a specific crystallite size. This in turn produces a highly stable alumina in the form of a calcined shaped alumina particularly at temperatures of 1200° C. and above.

Abstract: To extend a power cylinder bore in a hydraulic block of a power brake system, a cylinder cover, which is in the form of a cylinder tube and is closed at one end, is fastened by means of a circumferential caulking in a fastening groove of the hydraulic block which encloses the power cylinder bore. An interference fit of a fastening flange of the cylinder cover in the fastening groove reliably seals the cylinder cover against the hydraulic block in a pressure-proof manner.

Abstract: A membrane assembly for a humidification device of a fuel cell system may include a membrane. The membrane may be permeable to water and impermeable to air. The membrane may extend in a flat form in a longitudinal direction and in a transverse direction that is transverse with respect to the longitudinal direction in an extent plane. The membrane may include in a height direction extending transversely with respect to the longitudinal direction and transversely with respect to the transverse direction a top side and a bottom side averted from the top side. The membrane may include an encircling outer margin in the extent plane. The outer margin may have an upper edge at the top side and a lower edge at the bottom side, between which an encircling face surface extends.