Abstract: Provided herein are nucleic acid constructs, polypeptides and T cells related to antigen binding domains that bind to mutant calreticulin; and methods of use thereof for the treatment of diseases, including cancer.

Abstract: The invention generally relates to sequencing library preparation methods. In certain embodiments, two template nucleic acids are joined together by a linking molecule, such as a PEG derivative. The linked template nucleic acids is amplified, creating linked amplicons.

Abstract: Systems and methods for machine learning architecture for time series data prediction. The system may include a processor and a memory storing processor-executable instructions. The processor-executable instructions, when executed, may configure the processor to: obtain time series data associated with a data query; generate a predicted value based on a sampled realization of the time series data and a continuous time generative model, the continuous time generative model trained to define an invertible mapping to maximize a log-likelihood of a set of predicted values for a time range associated with the time series data; and generate a signal providing an indication of the predicted value associated with the data query.

Abstract: A modular reverse shoulder prosthesis, comprising: a stem (110) comprising a tapered body (111) and a first annular housing (112); a tray (120) comprising a dome element (121) for insertion into the first annular housing (112), and further comprising a second annular housing (122); a liner (130) comprising an engaging element (131) for at least partial insertion into the dome element (121), and further comprising a joint concave element (132) configured for coupling with the second annular housing (122). The second annular housing (122) of the tray (120) comprises a raised edge (123) configured to support the joint concave element (132) and which defines an overall outline having a different development in height at least in diametrically opposite portions (123a; 123b) of the tray (120).

Abstract: A pocketed spring assembly comprises parallel strings, each string joined to at least one adjacent string. At least some of the strings have springs of different gauge wire and some of the pockets of the strings having springs of different gauge wire are spliced together. At least some of the strings have springs of different geometries and some of the pockets of the strings having springs of different geometries are spliced together. At least some strings may have end sections with springs different than a middle section therebetween, the springs of the end sections being firmer than the springs of the middle section.

Abstract: A method for producing a bowl formed by a tray closed by a sealing film involves preparing a blank where a first and a second couples of crease lines delimit a bottom panel, two first and two second side walls, each first side wall provided of an internal flap and an external flap delimited by respective third and fourth crease lines, each second side wall provided of an internal flap and an external flap delimited by respective fifth and sixth crease lines, erecting the blank into a tray, folding the internal and external flaps of each first side wall about the respective third crease line and the internal and external flaps of each second side wall about the respective fifth crease line, applying adhesive on the internal and/or external flaps of each first and second side walls, folding the external flap of each first side wall about the respective fourth crease line and the external flap of each second side wall about the respective sixth crease line, forming a rim, applying adhesive on gaps between abutti

Abstract: There is provided a method performed by a wireless device for communicating with a network node in a wireless communication network. The method includes using a field in a Master Information Block (MIB) received by the wireless device, as an indication of a presence of an extended MIB (eMIB) and identifying which candidate resource of at least one candidate resource that contains the eMIB based on the indication of the presence of the eMIB. There is also provided a corresponding wireless device for communicating with a network node, a method perform by a network node, and a network node.

Abstract: A frequency linearity measurement circuit configured to measure a frequency linearity of a frequency signal includes: a first measurement circuit having a counter, where the counter is controlled by a gate signal having a gate signal period, where the first measurement circuit is configured to generate a first estimate of an integer number of clock cycles of the frequency signal within a respective gate signal period of the gate signal; a second measurement circuit having a time-to-digital converter (TDC), where the TDC is controlled by the gate signal, and is configured to generate a second estimate of a fractional number of clock cycle of the frequency signal within the respective gate signal period of the gate signal; and a reference measurement circuit configured to generate a third estimate of an expected number of clock cycles within the respective gate signal period of the gate signal.

Abstract: The invention relates to a method for compensating positioning error in an edging process or in a fastening operation for a raw-edged, finished spectacle lens, the method comprising: —determining centring deviation parameters, said centring deviation parameters indicating the occurrence of positioning errors for the raw-edged, finished spectacle lens during a fastening operation and/or during a subsequent edging process, and—modifying control information with the aid of the determined centring deviation parameters such that the positioning errors for the raw-edged, finished spectacle lens are compensated and/or taken into account. The invention also related to a corresponding device.

Abstract: A method of producing an integrated monolithic aluminum structure including providing an 7xxx-series aluminum alloy plate with a predetermined thickness of at least 10 mm, and wherein the plate has been solution heat treated and stretched, heat-treating the plate product in a first of a plurality of artificial ageing steps required to achieve a final temper state, high-energy hydroforming the plate against a forming surface of a rigid die having a contour with a desired curvature of the integrated monolithic aluminum structure, the high energy forming causing the aluminum alloy plate to conform to the forming surface contour to at least one of a uniaxial curvature and a biaxial curvature, heat-treating the integrated monolithic aluminum structure through a remaining ageing step of the ageing steps to achieve a desired final temper, and machining the high-energy formed structure to a near-final or final machined integrated monolithic aluminum structure.

Abstract: A method for activating an automated parking maneuver to be carried out via a parking assistance system with a motor vehicle is provided. The parking assistance system can be operated remotely from outside the motor vehicle by way of a mobile communications device. The method includes outputting an instruction via the mobile communications device for the user-side execution of a predefined activation movement of the mobile communications device; determining first sensor information relating to the activation movement of the communications device by way of a communications-device-side sensor system; detecting an activation movement of the mobile communications device carried out by the mobile communications device based on the first sensor information; and activating the parking maneuver according to the detection of the activation movement of the mobile communications device.

Abstract: An optical range calculation apparatus (100) comprises a light source configured to emit light in accordance with an indirect time of flight measurement technique. A photonic mixer cell (102) is configured to generate and store a plurality of electrical output signals respectively corresponding to a plurality of predetermined phase offset values applied (112) in accordance with the indirect time of flight measurement technique. A signal processing circuit (110, 124) is configured to process the plurality of electrical output signals in accordance with the indirect time of flight measurement technique in order to calculate a measurement vector and a measured phase angle from the measurement vector.

Abstract: The present invention falls within the technical field of aquaculture, and specifically, the invention relates to a specific solution for preventing and treating bacterial diseases using a Lactococcus lactis lactic acid bacterium transformed to produce an interferon type II (IFN II) immunostimulating cytokine, particularly interferon gamma (IFNg or IFNy). Said transformed bacterium has been deposited in the Chilean Microbial Genetic Resources Collection at INIA with accession number RGM 2416 dated 22 Oct. 2017.

Abstract: A method for operating a magnetic resonance device is provided. The magnetic resonance device includes a component that has an operating limit in relation to a state parameter. The component uses a protocol to record magnetic resonance data. The protocol includes a magnetic resonance sequence and is described by protocol parameters. A protocol parameter set that, in relation to a protocol section, allows the protocol section to be repeated as often as desired without exceeding the operating limit is provided or determined. The method includes receiving a boost parameter from a user interface. At least for the protocol section, adaptation parameters are determined at least partially automatically based on the boost parameter, such that the desired number of repetitions described by the boost parameter is established while complying with the operating limit. Magnetic resonance data is recorded with the protocol using the determined adaptation parameters.

Abstract: An apparatus including memory access circuitry for controlling access to data stored in the non-trusted memory, and memory security circuitry to verify integrity of data stored in the non-trusted memory. The memory security circuitry has authentication code generation circuitry for generating authentication codes to be associated with the data stored in the non-trusted memory, for use when verifying the integrity of the data. The apparatus also has a trusted storage, and the authentication code generation circuitry is arranged to generate different authentication codes, dependent on whether the authentication code is to be stored in the non-trusted memory or the trusted storage.