Abstract: The invention provides compositions and methods for cancer immunotherapy. Specifically, the invention provides an antigen-presenting cell, for example, a dendritic cell that comprises a tumor mitochondrial molecule or a tumor mitochondrial molecule derived from tumor mitochondrial protein lysate or a specific mitochondria derived protein of mitochondrial protein lysate as antigen source.

Abstract: The present invention relates to a device for generating laser radiation. An object of the present invention is to indicate a laser diode which simultaneously has a high degree of efficiency and a low degree of far field divergence. The diode laser according to the invention comprises a current barrier (5), characterized in that the current barrier (5) extends along a third axis (X), wherein the current barrier (5) has at least one opening, and a first width (W1) of the opening of the current barrier (5) along the third axis (X) is smaller than a second width (W2) of the metal p-contact (8) along the third axis (X).

Abstract: A rod seal assembly for a machine includes a crosshead and a sealed oscillating piston rod.

Abstract: The present invention provides an inhaler comprising a housing which contains a blister strip having a plurality of blisters which contain powdered medicament for inhalation, a mouthpiece mounted to the housing through which the medicament is inhaled by a user, an indexing and opening mechanism for indexing the blister strip and for opening the blisters which is operated by an actuator, wherein the blister strip is indexed by forward motion of the actuator from a first position to a second position, such as by opening a cover, and is also indexed in the same direction by reverse motion of the actuator from the second positon to the first position, such as by closing the cover.

Abstract: Methods, systems, and computer programs for generating a playlist of media content items for a group of users. Media content items listened to by the selected users are compared to an average user taste profile to select media content items for playback to the group of users.

Abstract: The present invention relates to an isolated antibody or antigen-binding fragment thereof that binds to human A2AP. The isolated antibody or antigen-binding fragment according to the present invention i) cross-reacts with rabbit and/or cynomolgus A2AP, ii) does not inhibit human plasmin activity, and iii) increases plasmin mediated clot lysis in the presence of A2AP.

Abstract: In an embodiment an arrangement includes a plurality of optoelectronic semiconductor components arranged in a common plane, wherein each semiconductor component is laterally delimited by side faces, and wherein each semiconductor component includes a semiconductor body having an active region configured to emit electromagnetic radiation, a radiation outlet side configured to couple out the electromagnetic radiation, a rear face opposite to the radiation outlet side, and a contact structure arranged on the rear face, an output element, an electrically insulating insulation layer and an electrical connection structure, wherein the insulation layer is arranged between side faces of adjacent semiconductor components, wherein the output element is arranged at the radiation outlet sides of the semiconductor components, wherein the electrical connection structure is electrically conductively connected with the contact structure, and wherein the connection structure includes an adhesive layer, a growth layer and a co

Abstract: The present invention provides an inhaler comprising a housing which contains a blister strip having a plurality of blisters which contain powdered medicament for inhalation; a mouthpiece through which the medicament is inhaled by a user; an indexing wheel for indexing the blister strip; an opening mechanism for opening the blisters; an actuator which is movable between a first position and a second position in order to operate the indexing wheel and the opening mechanism; and a coupling mechanism for coupling the actuator to the indexing wheel so that the indexing wheel rotates together with the actuator during part of the motion of the actuator; characterized in that the coupling mechanism comprises a shuttle that rotates on the same axis as, and translates axially relative to, the indexing wheel.

Abstract: An arrangement for the assembly and wiring of electrical components in switchgear construction, the arrangement comprising a robot with an end effector designed as a gripper, a mounting plate holding device, with which a mounting plate is held in a mounting position with respect to the robot, and a component supply in the access area of the robot, via which components to be mounted on the mounting plate are provided for removal by the robot, wherein a controller of the robot has machine data for controlling the robot including position data for the arrangement of components on a mounting plane of a mounting plate to be equipped, wherein the robot has an optical imaging system which is adapted to detect an orientation of a mounting plate with respect to the robot, the controller of the robot being adapted to provide the position data with an offset representing the orientation of the mounting plate with respect to the robot as a function of the detected orientation. A corresponding method is further described.

Abstract: A cookie molding machine having a removable belt cassette for a conveyor belt and/or a cutting tool of a new type and/or a foldable second conveying device having externally closed joints and/or a funnel having removable funnel plates and/or a roller locking system of a new type.

Abstract: The present disclosure relates to a floating-point computation circuit comprising: an internal memory (104, 114) storing one or more floating-point values in a first format; status registers (124) defining a plurality of floating-point number format types associated with corresponding identifiers, each format type indicating at least a maximum size (BIS, MBB); and a load and store unit (108, 118) for loading floating-point values from and storing floating-point values to an external memory (120, 122), the load and store unit (108, 118) being configured: to receive, in relation with a first store operation, a first floating-point value from the internal memory (104, 114) and a first of said identifiers; and to convert the first floating-point value from the first format to a first external memory format having a maximum size (BIS, MBB) defined by the floating-point number format type designated by the first identifier.

Abstract: Methods, systems, and devices for techniques for forming self-aligned memory structures are described. Aspects include etching a layered assembly of materials including a first conductive material and a first sacrificial material to form a first set of channels along a first direction that creates a first set of sections. An insulative material may be deposited within each of the first set of channels and a second sacrificial material may be deposited onto the first set of sections and the insulating material. A second set of channels may be etched into the layered assembly of materials along a second direction that creates a second set of sections, where the second set of channels extend through the first and second sacrificial materials. Insulating material may be deposited in the second set of channels and the sacrificial materials removed leaving a cavity. A memory material may be deposited in the cavity.

Abstract: A method, wireless device and network node for performing sounding reference signal (SRS) transmission. According to one aspect a method includes receiving a definition of one or more SRS resource sets to be configured, comprising at least one SRS transmission setting. The method further includes receiving an indication of a selected SRS resource set to use for a SRS transmission, from the one or more configured SRS resource sets and determining a precoding configuration for the SRS transmission based on the selected SRS resource set and the at least one SRS transmission setting. The method also includes transmitting a SRS according to the determined precoding configuration.

Abstract: A modular dispenser includes a cartridge configured to hold a plurality of pills. A dispensing base is configured to removably receive the cartridge. The dispensing base includes a funnel with a funnel inlet proximate the opening of the cartridge and a funnel outlet spaced apart from the funnel inlet. A drawer is configured to receive the at least one pill from the funnel outlet in a well and is configured to be slidably received within the dispensing base. A metering flap may be movably positioned between the funnel outlet and the well of the drawer. The metering flap is pivotably coupled to at least one of the funnel and the dispensing base and may be configured to one of a) at least partially block and b) fully block the funnel outlet when the drawer is slidably extended away from the dispensing base.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: Systems and methods for use in automatic alignment of prefabricated building modules. Mating alignment structures on a new module and one more placed modules or mounted pilots interact as the new module is lowered to align edges of the new module relative to the placed components. Different alignment structure types are used to provide different degrees of positional alignment for different edges of a module during installation. When two edges of a module are simultaneously constrained, a horizontal position of one edge is constrained to a greater degree than the second edge. Alignment structures also can be configured so the degree of position constraint on a particular edge varies and to change which module edges are constrained as a module is lowered into position. The system and methods are suitable for use with prefabricated building modules having preinstalled interlocking façade panels.

Abstract: A conductor track arrangement for high-frequency signals is provided. The arrangement has a carrier and a layered signal conductor arranged on the carrier. The layered signal conductor is delimited by a first end, a second end, an inner edge, and an outer edge. The layered signal conductor changes direction in a deflection area and has a minimum width in the deflection area. At least one of the inner and outer edges has a curvature in the deflection area. The deflection area is between the first and second ends.

Abstract: The example embodiments are directed to systems and methods which can generate a process graph with important process insights in a manner that is significantly faster and more scalable than related art approaches and answers questions most customers have through the use of standardization. In one example, a method may include querying a data store for document data of a process, identifying a plurality of milestones that occur within the process and blockers that prevent at least one of the milestones from completing based on the document data, generating a graph model of the process based on a predefined template, wherein the graph model comprises a plurality of nodes corresponding to the plurality of milestones and edges between the plurality of nodes based on the blockers, and displaying the graph model of the process via a user interface.

Abstract: The invention relates to new pyridinyl sulfonamide derivatives of the formula wherein R1, A and n are as defined herein, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.