Abstract: A method for preparing a sterilised drug delivery device (1) comprising a fluid medication, the method comprising the steps of: providing a prefilled barrel (10) containing the fluid medication, the barrel being sealed with a stopper; placing the prefilled barrel, a plunger rod (20) and a finger grip (30) in a package such that the prefilled barrel, the plunger rod and the finger grip are separated from each other, wherein one side of the package is formed by a gas-permeable sheet (40); closing and sealing the package; and exposing the sealed package to a sterilant gas under conditions such that external surfaces of the prefilled barrel, the plunger rod and the finger grip are sterilised, wherein the package is a tray (50) comprising a cavity (51) formed therein wherein the cavity comprises at least three separate compartments (51a, 51b, 51c) adapted to the respective shapes of the components of the device for placement therein, and wherein the each of the prefilled barrel, the plunger rod and the finger grip

Abstract: The present disclosure provides methods and compositions useful for treating metastatic breast cancer in a subject in need thereof. The methods include measuring gene expression in breast cancer cells obtained from the subject, and administering an anticancer therapeutic to the subject.

Abstract: The present application relates to a conjugate comprising an amatoxin, a target-binding moiety wherein the target is CD20, i.e., a CD20-binding moiety, and optionally a linker linking said amatoxin and said CD20-binding moiety. The invention further relates to the synthesis of said conjugate. In addition, the invention relates to a pharmaceutical composition comprising such conjugate, particularly for use in the treatment of B-cell and/or lymphoma associated diseases and/or malignancies.

Abstract: A gas turbine engine for an aircraft comprises an engine core comprising a turbine, a combustor, a compressor, and a core shaft connecting the turbine to the compressor. The engine comprises a fan located upstream of the engine core and arranged to be driven by the core shaft. The engine comprises a nacelle surrounding the fan and the engine core and defining a bypass duct located radially outside of the engine core, where the bypass ratio, defined as the ratio of the mass flow rate of the flow through the bypass duct to the mass flow rate of the flow through the core at cruise conditions, is greater than or equal to 4. The engine comprises a plurality of actuators and a fuel supply system. The fuel supply system is arranged to supply fuel for combustion in the combustor, and to supply fuel to fueldraulically drive at least ten of the plurality of actuators.

Abstract: A gas turbine engine for an aircraft includes an engine core with a turbine, a combustor, a compressor, and a core shaft connecting the turbine to the compressor. The engine includes a fan upstream of the engine core driven by the core shaft. The engine includes a nacelle surrounding the fan and the engine core and defining a bypass duct located radially outside the engine core, where the bypass ratio of the mass flow rate through the bypass duct to the mass flow rate through the core at cruise conditions, is greater than or equal to 4. The engine includes a plurality of actuated engine systems, including a heat management system and a turbine case cooling system. The engine includes a fuel supply system arranged to supply fuel for combustion in the combustor, and to supply fuel to fueldraulically drive at least three of the plurality of actuated engine systems.

Abstract: Printed circuit board (100) for electrical components (5) and/or conductor paths (4), comprising: a base body (2) which extends along a main extension plane (HSE), and an insert (1) which is integrated into the base body (2) in the assembled state, wherein the insert (1) is a metal-ceramic substrate (10), the metal-ceramic substrate (1) being covered, in particular surrounded, at least partially by an insulating element (8) on a side surface (SF) facing the base body (2) in the assembled state.

Abstract: The present invention relates to a library of synthetic polynucleotides encoding TCR alpha chain constant regions and TCR beta chain constant regions for enhanced paring of recombinant TCR alpha and TCR beta chains and/or enhanced surface expression of recombinant TCRs. The invention further refers to corresponding vector libraries, TCR libraries, cell libraries and methods for isolating TCRs with enhanced TCR alpha and TCR beta chain pairing using said libraries and TCRs isolated from said libraries.

Abstract: The present disclosure provides methods of treating subjects having liver disease, and methods of identifying subjects having an increased risk of developing liver disease.

Abstract: AMENDMENTS TO THE ABSTRACT The invention relates to a composition containing, as active ingredient, ectoine, hydroxyectoine and/or salts, esters or amides of these compounds for the treatment and/or prophylaxis of diseases of the eye that are associated with a disturbance of the tear film. The disease can be in particular keratoconjunctivitis sicca. It has been found that, surprisingly, these compounds are capable of preventing a rupture in the outer lipid layer of the tear film, avoiding an undesirably rapid evaporation of the lacrimal fluid.

Abstract: A wrapper machine has a coiling station for forming a coil of a flexible article with an elongated shape, a packaging station for wrapping a stretch film around the coil, and a transfer unit for transferring the coil from the coiling station to a packaging station, where the coil is wrapped in a stretch film and moved intermittently around a rotation axis by two holding jaws mounted to rotate due to the thrust of respective crank mechanisms connected with an electric motor via an interposed transmission shaft.

Abstract: Obtaining a processed spherical image includes obtaining a first luminance thumbnail image for a first hemispherical input image, obtaining a second luminance thumbnail image for a second hemispherical input image, obtaining a first distortion correcting weight map, obtaining a second distortion correcting weight map, obtaining, as an aggregate weighted mean value for the input spherical image, an aggregate of a first normalized weighted mean value for the first luminance thumbnail image and a second normalized weighted mean value for the second luminance thumbnail image, obtaining at least one of a target exposure value, a target aggregate gain value, or a region of interest ratio value in accordance with the aggregate weighted mean value, and obtaining the processed spherical image from the input spherical image in accordance with at least one of the target exposure value, the target aggregate gain value, or the region of interest ratio value.

Abstract: An extended antenna port table includes both legacy Demodulation Reference Symbols, DMRS, and extended DMRS (e.g., Rel-18 DMRS). A UE obtains an indication of the extended antenna port table, either from configured information in memory or from the network, such as via RRC signaling. The indication may be of a subset of the extended antenna port table. The network sends the UE an index into the extended antenna port table, from which the UE determines one or more DMRS ports to use (one per layer). The extended DMRS ports in the extended antenna port table that are the same as corresponding legacy DMRS ports reuse the legacy DMRS port numbers; and extended DMRS ports that are different than legacy DMRS ports use DMRS port numbers not used by legacy DMRS ports. In one embodiment, the network switches the UE between using legacy and extended antenna port tables via a MAC-CE.

Abstract: The invention relates to a contact partner, in particular designed as a socket contact, which can be connected to a pin contact to form a plug connection, wherein the socket contact is designed as a punched-out and rolled part and has a contact region as well as a connection zone, in particular a crimped region, wherein the contact region is formed by a main body with a peripheral housing and two spaced-apart rings are provided within the housing, which are connected to one another via at least one elongated contact spring, wherein one end of the main body is connected to the connection zone, via a transition region, at an angle within a range of between 85° and 95° (in relation to the longitudinal axis of the main body).

Abstract: A data protection safeguarding analytics system for federated patient data, at least has a plurality of analytics environments which are separate from one another spatially as well as system-wise, which in each case include at last one local patient analytics database comprising a portion of the federated patient data, and which in each case include at least one local analytics module that is configured at least for an execution of scripts on the portion of the federated patient data available in the respective local patient analytics database, the data protection safeguarding analytics system further having at least one external operator and/or programming interface system, which is in particular arranged centrally or distributedly, which is separate from the analytics environments spatially and system-wise, by means of which the scripts that can be executed by the local analytics modules can be—in particular externally—created and/or provided, and which is with regard to data transfer connected to each of t

Abstract: A method of operating a gas turbine engine including: a core including a turbine, compressor, combustor to combust fuel, and core shaft connecting the turbine and compressor; a fan upstream of the core; a fan shaft; a bearing supporting the fan shaft; an oil loop system to supply oil to the bearing; and a heat exchange system including: an air-oil heat exchanger through which oil in the oil loop system flows; and a fuel-oil heat exchanger through which oil in the oil loop system and fuel flow to transfer heat between the oil and the fuel; a bypass pipe allowing a proportion of the oil to flow past one of the air-oil or the fuel-oil heat exchanger; and a bypass valve allowing the proportion of the oil sent through the bypass pipe to be varied. Under idle conditions, a heat transfer ratio of: rate ? of ? heat ? transfer ? from ? oil ? to ? air ? ( kJkg - 1 ) rate ? of ? heat ? transfer ? from ? oil ? to ? fuel ? ( kJkg - 1 ) is from 0 to 1.5.

Abstract: The invention relates to a wind turbine comprising: a nacelle provided on the top of a tower, a rotor including a hub and a number of blades, a main shaft configured to be driven by the rotor about a main axis and supported on the nacelle, a generator having a generator rotor and generator stator, and a gear system arranged to increase the rotational speed between said rotor and said generator rotor. The gear system comprises: a fixed ring gear, an input member coupled to or driven by the main shaft having a plurality of radially movable tooth segments carried in guiding slots and engageable at outer ends with the ring gear, a central output member within the input member having an outer eccentric profile acted on and driven by inner ends of radially movable tooth segments, whereby rotary movement of the input member drives the radially movable tooth segments through engagement with the ring gear and effects rotation of the central output member.

Abstract: A method for calibrating a measurement scanner on a laser-working optical unit of a laser working device includes creating a measurement scan of a test body using a measurement beam, and comparing measurement scan data the measurement scan with reference data of the test body, and if the measurement scan data of the measurement scan deviate from the reference data, correcting the measurement scanner so that the measurement scan data and the reference data of the test body match.

Abstract: A method of operating a gas turbine engine including an engine core having a turbine, a compressor, a combustor arranged to combust a fuel, and a core shaft connecting the turbine to the compressor; a fan located upstream of the engine core; a gearbox that receives an input from the core shaft and outputs drive to the fan so as to drive the fan; an oil loop system arranged to supply oil to gearbox; and a heat exchange system including an air-oil heat exchanger through which the oil flows; a fuel-oil heat exchanger through which the oil and the fuel flow; and an air valve arranged to control flow rate of air through the air-oil heat exchanger, the method including determining at least one fuel characteristic and controlling the air valve based on the fuel characteristic so as to adjust the flow rate of air through the air-oil heat exchanger.

Abstract: A method of operating an aircraft gas turbine engine including: a core including a turbine, a compressor, a combustor to combust fuel, and a core shaft connecting the turbine to the compressor; a fan upstream of the core; a fan shaft; a bearing supporting the fan shaft; an oil loop system supplying oil to the bearing; and a heat exchange system including: an air-oil heat exchanger through which oil in the oil loop system flows; and a fuel-oil heat exchanger through which oil in the oil loop system and fuel flow to transfer heat between the oil and the fuel; and a bypass pipe to allow a proportion of the oil to flow past one of the air-oil and the fuel-oil heat exchanger; and a bypass valve to allow the proportion of the oil sent through the bypass pipe to be varied.

Abstract: There is provided a method performed by a network node for configuring dynamic behavior of a spatial filter of a repeater node. The method comprises configuring the repeater node with one or more higher layer parameters. The one or more higher layer parameters define one or more beam time states. The method further comprises sending a dynamic indication to the repeater node indicating a beam and an associated beam time state. There is further provided a method performed by a repeater node. The method comprises receiving signaling, from a network node, configuring the repeater node with one or more higher layer parameters. The one or more higher layer parameters define one or more beam time states. The method further comprises receiving, from the network node, a dynamic indication indicating a beam and an associated beam time state.