Patents by Inventor Andrei Bakin

Andrei Bakin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF P53-DEFICIENT CANCERS
    Publication number: 20220249531
    Abstract: Provided are methods and formulations for the treatment of p53-deficient cancers using a combinational drug strategy which enhances DNA damage in p53 deficient cells while not allowing cells to escape cell death by activation of p53-p21 signaling. Wild-type p53 carriers, on the other hand, respond with activation of p53-p21 signaling and cell-cycle arrest, thereby escaping cell death. The methods involve administering to an individual in need of treatment a combination of one or more poly (ADP ribose) polymerase inhibitors (PARPi) and one or more deoxyuridine analogs. Pharmaceutical formulations comprising PARPi and dU analogs are also provided.
    Type: Application
    Filed: July 27, 2020
    Publication date: August 11, 2022
    Inventors: Andrei BAKIN, Justin ZONNEVILLE
  • TAK1 kinase inhibitors, compositions, and uses related thereto
    Patent number: 10093609
    Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a compound of formula I, and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula I to a subject in need thereof.
    Type: Grant
    Filed: September 4, 2017
    Date of Patent: October 9, 2018
    Assignee: Emory University
    Inventors: Huw M. L. Davies, Spandan Chennamadhavuni, Andrei Bakin
  • TAK1 Kinase Inhibitors, Compositions, and Uses Related Thereto
    Publication number: 20170369417
    Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a compound of formula I, and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula I to a subject in need thereof.
    Type: Application
    Filed: September 4, 2017
    Publication date: December 28, 2017
    Inventors: Huw M. L. Davies, Spandan Chennamadhavuni, Andrei Bakin
  • TAK1 kinase inhibitors, compositions, and used related thereto
    Patent number: 9751825
    Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula (I), pharmaceutical compositions having a compound of formula (I), and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula (I) to a subject in need thereof.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: September 5, 2017
    Assignee: Emory University
    Inventors: Huw M. L. Davies, Spandan Chennamadhavuni, Andrei Bakin
  • TAK1 KINASE INHIBITORS, COMPOSITIONS, AND USED RELATED THERETO
    Publication number: 20140249199
    Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula (I), pharmaceutical compositions having a compound of formula (I), and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula (I) to a subject in need thereof.
    Type: Application
    Filed: July 19, 2012
    Publication date: September 4, 2014
    Applicants: HEALTH RESEARCH, INC., EMORY UNIVERSITY
    Inventors: Huw M. L. Davies, Spandan Chennamadhavuni, Andrei Bakin