Patents by Inventor Andrei Chapoval

Andrei Chapoval has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies Directed To GPNMB And Uses Thereof
    Publication number: 20160311919
    Abstract: The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
    Type: Application
    Filed: February 25, 2016
    Publication date: October 27, 2016
    Inventors: Feng Xiao, Xiao-Chi Jia, Meina Liang, Orit Foord, Scott Klakamp, Kam Fai Tse, Vincent A. Pollack, Luca Rastelli, John Herrmann, Henri Lichenstein, Michael E. Jeffers, William J. LaRochelle, Gulshan Ara, Peter Mezes, Andrei Chapoval, Cyrus Karkaria, Michael Torgov, Juan Davagnino
  • Antibodies Directed to GPNMB and Uses Thereof
    Publication number: 20150044212
    Abstract: The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
    Type: Application
    Filed: August 7, 2014
    Publication date: February 12, 2015
    Inventors: Feng Xiao, Xiao-Chi Jia, Meina Liang, Orit Foord, Scott Klakamp, Kam Fai Tse, Vincent A. Pollack, Luca Rastelli, John Herrmann, Henri Lichenstein, Michael E. Jeffers, William J. LaRochelle, Gulshan Ara, Peter Mezes, Andrei Chapoval, Cyrus Karkaria, Michael Torgov, Juan Davagnino
  • Antibodies directed to GPNMB and uses thereof
    Patent number: 8846873
    Abstract: The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: September 30, 2014
    Assignees: Celldex Therapeutics, Inc., Amgen Fremont, Inc.
    Inventors: Feng Xiao, Xiao-Chi Jia, Meina Liang, Orit Foord, Scott Klakamp, Kam Fai Tse, Vincent A. Pollack, Luca Rastelli, John Herrmann, Henri Lichenstein, Michael Jeffers, William LaRochelle, Gulshan Ara, Peter Mezes, Andrei Chapoval, Cyrus Karkaria, Michael Torgov, Juan Davagnino
  • Antibodies Directed To GPNMB And Uses Thereof
    Publication number: 20130022597
    Abstract: The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.
    Type: Application
    Filed: January 20, 2012
    Publication date: January 24, 2013
    Inventors: Meina Liang, Orit Foord, Scott Klakamp, Vincent A. Pollack, Luca Rastelli, John Herrmann, Henri Lichenstein, Michael Jeffers, William LaRochelle, Peter Mezes, Andrei Chapoval, Cyrus Karkaria, Michael Torgov, Juan Davagnino
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20060003323
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: June 3, 2003
    Publication date: January 5, 2006
    Inventors: John Alsobrook, Enrique Alvarez, David Anderson, Ferenc Boldog, Stacie Casman, Elina Catterton, Andrei Chapoval, Julie Crabtree-Bokor, Shlomit Edinger, Karen Ellerman, Seth Ettenberg, Esha Gangolli, Valerie Gerlach, Linda Gorman, Erik Gunther, Xiaojia (Sasha) Guo, Vladimir Gusev, John Herrmann, Weizhen Ji, Ramesh Kekuda, Li Li, Xiaohong Liu, John MacDougall, Timothy Machlachlan, Uriel Malyankar, Amanda Mezick, Isabelle Millet, Vishnu Mishra, Muralidhara Padigaru, Meera Patturajan, Carol Pena, John Peyman, Debasish Raha, Luca Rastelli, Daniel Rieger, Mark Rothenberg, Paul Sciore, Suresh Shenoy, Richard Shimkets, Glennda Smithson, Kimberly Spytek, David Stone, Corine Vernet, Edward Voss, Mei Zhong, Hiahong Zhong
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040067882
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: November 5, 2002
    Publication date: April 8, 2004
    Inventors: John P. Alsobrook, Enrique Alvarez, David W. Anderson, Melanie Baron, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Andrei Chapoval, Mohanraj Dhanabal, Shlomit R. Edinger, Andrew Eisen, Karen Ellerman, Seth Ettenberg, Esha A. Gangolli, Valerie Gerlach, Linda Gorman, William M. Grosse, Xiaojia (Sasha) Guo, Craig Hackett, Weizhen Ji, Ramesh Kekuda, Nikolai V. Khramtsov, Denise M. Lepley, Li Li, John R. MacDougall, Uriel M. Malyankar, Ann Mazur, Kelly McQueeney, Peter S. Mezes, Charles E. Miller, Isabelle Millet, Vishnu Mishra, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, John A. Peyman, Luca Rastelli, Daniel K. Rieger, Mark E. Rothenberg, Suresh G. Shenoy, Richard A. Shimkets, Glennda Smithson, Steven K. Spaderna, Gary Starling, Kimberly A. Spytek, David J. Stone, Velizar T. Tchernev, Nancy Twomlow, Corine A.M. Vernet, Bryan D. Zerhusen, Edward Z. Voss, Mei Zhong
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040067490
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: September 6, 2002
    Publication date: April 8, 2004
    Inventors: Mei Zhong, Li Li, Linda Gorman, Kimberly A. Spytek, Ramesh Kekuda, Raymond J. Taupier, David W. Anderson, Corine A.M. Vernet, Elina Catterton, Charles E. Miller, Suresh G. Shenoy, Meera Patturajan, Carol E. A. Pena, Velizar T. Tchernev, Muralidhara Padigaru, Vladimir Y. Gusev, Uriel M. Malyankar, Catherine E. Burgess, Valerie Gerlach, Stacie J. Casman, Daniel K. Rieger, William M. Grosse, Glennda Smithson, John A. Peyman, Gary Starling, Mark E. Rothenberg, William J. LaRochelle, Richard A. Shimkets, Julie Crabtree, Luca Rastelli, Edward Z. Voss, Ferenc L. Boldog, Shlomit R. Edinger, Isabelle Millet, John R. MacDougall, Karen Ellerman, Andrei Chapoval
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20040038230
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: November 4, 2002
    Publication date: February 26, 2004
    Inventors: John P. Alsobrook, David W. Anderson, Ferenc L. Boldog, Catherine E. Burgess, John S. Chant, Andrei Chapoval, Amitabha Chaudhuri, Shlomit R. Edinger, Andrew Eisen, Esha A. Gangolli, Valerie Gerlach, Xiaojia Sasha Guo, Weizhen Ji, Nikolai V. Khramtsov, Mario W. Leite, Li Li, Peter S. Mezes, Isabelle Millet, Chean Eng Ooi, Tatiana Ort, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, Luca Rastelli, Daniel K. Rieger, Kerry E. Quinn Senger, Glennda Smithson, Steven K. Spaderna, Kimberly A. Spytek, David J. Stone, Nancy Twomlow, Corine A.M. Vernet, Edward Z. Voss, Bryan D. Zerhusen, Mei Zhong
  • Novel antibodies that bind to antigenic polypeptides, nucleic acids encoding the antigens, and methods of use
    Publication number: 20040018594
    Abstract: Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids, polypeptides, or antibodies, or fragments thereof.
    Type: Application
    Filed: May 1, 2002
    Publication date: January 29, 2004
    Inventors: John P. Alsobrook, David W. Anderson, Ferenc L. Boldog, Catherine E. Burgess, Stacie J. Casman, Andrei Chapoval, Shlomit R. Edinger, Valerie Gerlach, Linda Gorman, Erik Gunther, Xiaojia Sasha Guo, Ramesh Kekuda, Denise M. Lepley, Li Li, Xiaohong Liu, Uriel M. Malyankar, Charles E. Miller, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, Carol E. A. Pena, Daniel K. Rieger, Suresh G. Shenoy, Richard A. Shimkets, Kimberly A. Spytek, Raymond J. Taupier, Corine A.M. Vernet, Edward Z. Voss, Bryan D. Zerhusen
  • Therapeutic polypeptides, nucleic acids encoding same, and methods of use
    Publication number: 20030224982
    Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
    Type: Application
    Filed: July 2, 2002
    Publication date: December 4, 2003
    Inventors: Li Li, Suresh G. Shenoy, Meera Patturajan, Karen Ellerman, Linda Gorman, Mei Zhong, Elina Catterton, Kimberly A. Spytek, Charles E. Miller, Shlomit R. Edinger, Tord Hjalt, Valerie Gerlach, Richard A. Shimkets, Raymond J. Taupier, David W. Anderson, Xiaojia (Sasha) Guo, Jason C. Baumgartner, Muralidhara Padigaru, John A. Peyman, Glennda Smithson, Stacie J. Casman, Edward Z. Voss, Ferenc L. Boldog, Carol E. A. Pena, Andrei Chapoval, Luca Rastelli, Ramesh Kekuda, Corine A.M. Vernet