Patents by Inventor Andrei Egorov

Andrei Egorov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Interferon inducing genetically engineered attenuated viruses
    Patent number: 6866853
    Abstract: The present invention relates to genetically engineered attenuated viruses and methods for their production. In particular, the present invention relates to engineering live attenuated viruses which contain a modified NS gene segment. Recombinant DNA techniques can be utilized to engineer site specific mutations into one or more noncoding regions of the viral genome which result in the down-regulation of one or more viral genes. Alternatively, recombinant DNA techniques can be used to engineer a mutation, including but not limited to an insertion, deletion, or substitution of an amino acid residue(s) or an epitope(s) into a coding region of the viral genome so that altered or chimeric viral proteins are expressed by the engineered virus.
    Type: Grant
    Filed: December 9, 2002
    Date of Patent: March 15, 2005
    Assignee: Mount Sinai School of Medicine of New York University
    Inventors: Andrei Egorov, Thomas Muster, Adolfo Garcia-Sastre, Peter Palese, Sabine Brandt
  • Interferon inducing genetically engineered attenuated viruses
    Publication number: 20030157131
    Abstract: The present invention relates to genetically engineered attenuated viruses and methods for their production. In particular, the present invention relates to engineering live attenuated viruses which contain a modified NS gene segment. Recombinant DNA techniques can be utilized to engineer site specific mutations into one or more noncoding regions of the viral genome which result in the down-regulation of one or more viral genes. Alternatively, recombinant DNA techniques can be used to engineer a mutation, including but not limited to an insertion, deletion, or substitution of an amino acid residue(s) or an epitope(s) into a coding region of the viral genome so that altered or chimeric viral proteins are expressed by the engineered virus.
    Type: Application
    Filed: December 9, 2002
    Publication date: August 21, 2003
    Applicant: Mount Sinai School of Medicine
    Inventors: Andrei Egorov, Thomas Muster, Adolfo Garcia-Sastre, Peter Palese, Sabine Brandt
  • Interferon inducing genetically engineered attenuated viruses
    Patent number: 6468544
    Abstract: The present invention relates to genetically engineered attenuated viruses and methods for their production. In particular, the present invention relates to engineering live attenuated viruses which contain a modified NS gene segment. Recombinant DNA techniques can be utilized to engineer site specific mutations into one or more noncoding regions of the viral genome which result in the down-regulation of one or more viral genes. Alternatively, recombinant DNA techniques can be used to engineer a mutation, including but not limited to an insertion, deletion, or substitution of an amino acid residue(s) or an epitope(s) into a coding region of the viral genome so that altered or chimeric viral proteins are expressed by the engineered virus.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: October 22, 2002
    Assignee: Mount Sinai School of Medicine of the City University of New York
    Inventors: Andrei Egorov, Thomas Muster, Adolfo García-Sastre, Peter Palese, Sabine Brandt