Patents by Inventor Andrei Gindilis
Andrei Gindilis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11939629Abstract: The current document relates generally to the field of nucleic-acid detection and, in particular, to a highly sensitive and specific nucleic-acid-detection method that includes hybridization of a specific nucleic-acid target to a recognition probe, subsequent specific cleavage of the double-stranded target-probe helix at a specific restriction site, and exponential amplification of the enzymatic cleavage accompanied by release of a molecular marker.Type: GrantFiled: August 1, 2018Date of Patent: March 26, 2024Inventor: Andrei Gindilis
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Patent number: 11724243Abstract: There is disclosed an electrode array device having an adsorbed porous reaction layer for improved synthesis quality. The array comprises a plurality of electrodes on a substrate, wherein the electrodes are electronically connected to a computer control system. The array has an adsorbed porous reaction layer on the plurality of electrodes, wherein the adsorbed porous reaction layer comprises a chemical species having at least one hydroxyl group. In the preferred embodiment, the reaction layer is sucrose. A method for preparing an electrode array for improved synthesis quality is disclosed. The method comprises a cleaning method and a method of attachment of a reaction layer. The cleaning method comprises a plasma cleaning method and a chemical cleaning method. The reaction layer is attached after cleaning by exposing the microarray to a solution containing the chemical species having at least one hydroxyl group.Type: GrantFiled: May 2, 2019Date of Patent: August 15, 2023Assignee: CustomArray, Inc.Inventor: Andrei Gindilis
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Publication number: 20190255504Abstract: There is disclosed an electrode array device having an adsorbed porous reaction layer for improved synthesis quality. The array comprises a plurality of electrodes on a substrate, wherein the electrodes are electronically connected to a computer control system. The array has an adsorbed porous reaction layer on the plurality of electrodes, wherein the adsorbed porous reaction layer comprises a chemical species having at least one hydroxyl group. In the preferred embodiment, the reaction layer is sucrose. A method for preparing an electrode array for improved synthesis quality is disclosed. The method comprises a cleaning method and a method of attachment of a reaction layer. The cleaning method comprises a plasma cleaning method and a chemical cleaning method. The reaction layer is attached after cleaning by exposing the microarray to a solution containing the chemical species having at least one hydroxyl group.Type: ApplicationFiled: May 2, 2019Publication date: August 22, 2019Applicant: CUSTOMARRAY, INC.Inventor: Andrei Gindilis
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Publication number: 20190185920Abstract: The current document relates generally to the field of nucleic-acid detection and, in particular, to a highly sensitive and specific nucleic-acid-detection method that includes hybridization of a specific nucleic-acid target to a recognition probe, subsequent specific cleavage of the double-stranded target-probe helix at a specific restriction site, and exponential amplification of the enzymatic cleavage accompanied by release of a molecular marker.Type: ApplicationFiled: August 1, 2018Publication date: June 20, 2019Inventor: Andrei Gindilis
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Patent number: 10286377Abstract: There is disclosed an electrode array device having an adsorbed porous reaction layer for improved synthesis quality. The array comprises a plurality of electrodes on a substrate, wherein the electrodes are electronically connected to a computer control system. The array has an adsorbed porous reaction layer on the plurality of electrodes, wherein the adsorbed porous reaction layer comprises a chemical species having at least one hydroxyl group. In the preferred embodiment, the reaction layer is sucrose. A method for preparing an electrode array for improved synthesis quality is disclosed. The method comprises a cleaning method and a method of attachment of a reaction layer. The cleaning method comprises a plasma cleaning method and a chemical cleaning method. The reaction layer is attached after cleaning by exposing the microarray to a solution containing the chemical species having at least one hydroxyl group.Type: GrantFiled: May 15, 2016Date of Patent: May 14, 2019Assignee: CustomArray, Inc.Inventor: Andrei Gindilis
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Patent number: 9339782Abstract: There is disclosed an electrode array device having an adsorbed porous reaction layer for improved synthesis quality. The array comprises a plurality of electrodes on a substrate, wherein the electrodes are electronically connected to a computer control system. The array has an adsorbed porous reaction layer on the plurality of electrodes, wherein the adsorbed porous reaction layer comprises a chemical species having at least one hydroxyl group. In the preferred embodiment, the reaction layer is sucrose. A method for preparing an electrode array for improved synthesis quality is disclosed. The method comprises a cleaning method and a method of attachment of a reaction layer. The cleaning method comprises a plasma cleaning method and a chemical cleaning method. The reaction layer is attached after cleaning by exposing the microarray to a solution containing the chemical species having at least one hydroxyl group.Type: GrantFiled: November 18, 2013Date of Patent: May 17, 2016Assignee: CustomArray, Inc.Inventor: Andrei Gindilis
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Publication number: 20120245049Abstract: A method of performing a fluid-material assay employing a device including at least one active pixel having a sensor with an assay site functionalized for selected fluid-assay material. The method includes exposing the pixel's sensor assay site to such material, and in conjunction with such exposing, and employing the active nature of the pixel, remotely requesting from the pixel's sensor assay site an assay-result output report. The method further includes, in relation to the employing step, creating, relative to the sensor's assay site in the at least one pixel, a predetermined, pixel-specific electromagnetic field environment.Type: ApplicationFiled: June 5, 2012Publication date: September 27, 2012Inventors: John W. Hartzell, Pooran Chandra Joshi, Paul J. Schuele, Andrei Gindilis
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Patent number: 8232109Abstract: A method of performing a fluid-material assay employing a device including at least one active pixel having a sensor with an assay site functionalized for selected fluid-assay material. The method includes exposing the pixel's sensor assay site to such material, and in conjunction with such exposing, and employing the active nature of the pixel, remotely requesting from the pixel's sensor assay site an assay-result output report. The method further includes, in relation to the employing step, creating, relative to the sensor's assay site in the at least one pixel, a predetermined, pixel-specific electromagnetic field environment.Type: GrantFiled: July 31, 2007Date of Patent: July 31, 2012Assignee: Sharp Laboratories of America, Inc.Inventors: John W. Hartzell, Pooran Chandra Joshi, Paul J. Schuele, Andrei Gindilis
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Publication number: 20080085559Abstract: A method of performing a fluid-material assay employing a device including at least one active pixel having a sensor with an assay site functionalized for selected fluid-assay material. The method includes exposing the pixel's sensor assay site to such material, and in conjunction with such exposing, and employing the active nature of the pixel, remotely requesting from the pixel's sensor assay site an assay-result output report. The method further includes, in relation to the employing step, creating, relative to the sensor's assay site in the at least one pixel, a predetermined, pixel-specific electromagnetic field environment.Type: ApplicationFiled: July 31, 2007Publication date: April 10, 2008Inventors: John W. Hartzell, Pooran Chandra Joshi, Paul J. Schuele, Andrei Gindilis
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Publication number: 20070037169Abstract: The present invention provides a method for selective dehybridization by electrochemically-generated (ECG) reagent on an electrode microarray. The ECG reagent is generated by activation of selected electrodes. Activation alters pH in the vicinity of only the selected electrodes. In one embodiment, the increase or decrease in pH is sufficient to cause dehybridization of an oligonucleotide duplex at the selected electrodes. In another embodiment, the increase or decrease in pH is sufficient to prevent chemical dehybridization at the selected electrodes. The dehybridized single stranded target oligonucleotide may be recovered and amplified by PCR.Type: ApplicationFiled: August 9, 2005Publication date: February 15, 2007Applicant: COMBIMATRIX CORPORATIONInventors: John Cooper, Andrei Gindilis
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Publication number: 20060102471Abstract: There is disclosed an electrode array device having an adsorbed porous reaction layer for improved synthesis quality. The array comprises a plurality of electrodes on a substrate, wherein the electrodes are electronically connected to a computer control system. The array has an adsorbed porous reaction layer on the plurality of electrodes, wherein the adsorbed porous reaction layer comprises a chemical species having at least one hydroxyl group. In the preferred embodiment, the reaction layer is sucrose. A method for preparing an electrode array for improved synthesis quality is disclosed. The method comprises a cleaning method and a method of attachment of a reaction layer. The cleaning method comprises a plasma cleaning method and a chemical cleaning method. The reaction layer is attached after cleaning by exposing the microarray to a solution containing the chemical species having at least one hydroxyl group.Type: ApplicationFiled: November 18, 2004Publication date: May 18, 2006Inventors: Karl Maurer, John Cooper, Michael Strathmann, Andrei Gindilis