Patents by Inventor Andrei Guzaev

Andrei Guzaev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUPPORTS FOR OLIGOMER SYNTHESIS
    Publication number: 20080021224
    Abstract: Universal linkers, their facile processes of manufacture and methods of using the same are provided.
    Type: Application
    Filed: January 11, 2007
    Publication date: January 24, 2008
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Andrei Guzaev, Zhiwei Wang, Raju Kumar
  • PROCESS FOR THE SYNTHESIS OF OLIGOMERIC COMPOUNDS
    Publication number: 20070265435
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: April 5, 2007
    Publication date: November 15, 2007
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Daniel Capaldi, Achim Krotz, Douglas Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Patent number: 7227016
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: December 28, 2004
    Date of Patent: June 5, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Patent number: 7199236
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: September 14, 2004
    Date of Patent: April 3, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Oligonucleotides having alkylphosphonate linkages and methods for their preparation
    Patent number: 7049432
    Abstract: The present invention provides alkylphosphonate dimers and oligonucleotides prepared therefrom. The invention further provides novel methods for the preparation of these alkylphosphonate dimers. Methods for the preparation of substantially diastereomerically pure alkylphosphonate dimers are also provided.
    Type: Grant
    Filed: June 4, 2002
    Date of Patent: May 23, 2006
    Assignees: ISIS Pharmaceuticals, Inc., McGill University
    Inventors: Muthiah Manoharan, George Just, Andrei Guzaev, Arlène Roland, Jianchao Wang, Michael E. Jung
  • Process for the synthesis of oligomeric compounds
    Patent number: 7041816
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: May 9, 2006
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Supports for oligomer synthesis
    Publication number: 20050208588
    Abstract: Universal linkers, their facile processes of manufacture and methods of using the same are provided.
    Type: Application
    Filed: November 15, 2004
    Publication date: September 22, 2005
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Andrei Guzaev, Zhiwei Wang, Raju Kumar
  • Process for the synthesis of oligomeric compounds
    Publication number: 20050182251
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: December 28, 2004
    Publication date: August 18, 2005
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Daniel Capaldi, Achim Krotz, Douglas Cole, Andrei Guzaev
  • Synthetic methods and intermediates for triester oligonucleotides
    Patent number: 6919437
    Abstract: Methods for the preparation of oligonucleotides having bioreversible phosphate blocking groups are disclosed. In one aspect, the present invention provides compounds comprising a sequence of nucleotide units that includes a first segment having at least one internucleoside linkage of formula: 3?-O—P(X)(O?)—O-5? and a second segment having at least one internucleoside linkage of formula: 3?-O—P(X)(Y1—(CH2)q—Y2—Y3—Z)—O-5? wherein each of X, Y1, and Y2 is, independently, O or S; q is 2 to about 4; Y3 is C(?O) or S; and Z is aryl having 6 to about 14 carbon atoms or alkyl having from one to about six carbon atoms.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: July 19, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Muthiah Manoharan, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Publication number: 20050137390
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: December 28, 2004
    Publication date: June 23, 2005
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Daniel Capaldi, Achim Krotz, Douglas Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Publication number: 20050137391
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: September 14, 2004
    Publication date: June 23, 2005
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Daniel Capaldi, Achim Krotz, Douglas Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Patent number: 6858715
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: February 22, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Publication number: 20040219577
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: January 20, 2004
    Publication date: November 4, 2004
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Processes for the synthesis of oligomeric compounds
    Publication number: 20030153743
    Abstract: Methods for the preparation of oligonucleotides having bioreversible phosphate blocking groups are disclosed. The oligonucleotides are prepared utilizing amidite type chemistry wherein the bioreversible phosphorus protecting group is formed as an integral part of the amidite reagent.
    Type: Application
    Filed: January 3, 2003
    Publication date: August 14, 2003
    Inventors: Muthiah Manoharan, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Publication number: 20030088088
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: August 30, 2002
    Publication date: May 8, 2003
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Oligonucleotides having alkylphosphonate linkages and methods for their preparation
    Publication number: 20030078414
    Abstract: The present invention provides alkylphosphonate dimers and oligonucleotides prepared therefrom. The invention further provides novel methods for the preparation of these alkylphosphonate dimers. Methods for the preparation of substantially diastereomerically pure alkylphosphonate dimers are also provided.
    Type: Application
    Filed: June 4, 2002
    Publication date: April 24, 2003
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Muthiah Manoharan, George Just, Andrei Guzaev, Arlene Roland, Jianchao Wang, Michael E. Jung
  • Processes for the synthesis of oligonucleotide compounds
    Patent number: 6531590
    Abstract: Methods for the preparation of oligonucleotides having bioreversible phosphate blocking groups are disclosed. The oligonucleotides are prepared utilizing amidite type chemistry wherein the bioreversible phosphorus protecting group is formed as an integral part of the amidite reagent.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: March 11, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Muthiah Manoharan, Andrei Guzaev
  • Oligonucleotides having alkylphosphonate linkages and methods for their preparation
    Patent number: 6486313
    Abstract: The present invention provides alkylphosphonate dimers and oligonucleotides prepared therefrom. The invention further provides novel methods for the preparation of these alkylphosphonate dimers. Methods for the preparation of substantially diastereomerically pure alkylphosphonate dimers are also provided.
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: November 26, 2002
    Assignees: ISIS Pharmaceuticals, Inc., McGill University
    Inventors: Muthiah Manoharan, George Just, Andrei Guzaev, Arlène Roland, Jianchao Wang, Michael E. Jung
  • Process for the synthesis of oligomeric compounds
    Patent number: 6465628
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: October 15, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Chemical phosphorylation of oligonucleotides and reactants used therefor
    Patent number: 5959090
    Abstract: Phosphoramidite building blocks according to the following formula 1 are used for phosphorylating oligonucleotides, preferably at the 5'- or 3'-terminus. The building blocks include phosphoramidite compounds according to formula 1: ##STR1## wherein DMTr is a 4,4'-dimethoxytrityl group; R.sub.1 is an electron withdrawing group; R.sub.2 is an electron withdrawing group which may be the same or different from the R.sub.1 group; R.sub.3 is an alkyl group; and R.sub.4 is an alkyl group which may be the same or different from the R.sub.3 group. Preferred electron withdrawing groups include --CO.sub.2 Et groups, --CO.sub.2 Me groups, --CN groups, --CON(Me).sub.2 groups, and --CONHMe groups, wherein Et represents an ethyl group and Me represents a methyl group. One preferred alkyl group is an isopropyl group.
    Type: Grant
    Filed: July 1, 1997
    Date of Patent: September 28, 1999
    Assignee: Glen Research Corporation
    Inventors: Andrei Guzaev, Alex Azhayev, Harri Lonnberg