Patents by Inventor Andrei Konradi

Andrei Konradi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for treating rheumatoid arthritis
    Publication number: 20050074451
    Abstract: This application relates to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and an antibody to alpha-4 integrin or an immunologically active antigen binding fragment in therapeutically effective amounts. The application also relates generally to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and small molecule alpha-4 integrin antagonist that inhibits the alpha-4 integrin (?4 integrin) interaction with VCAM-1. The invention further relates to methods of preparing the compounds and methods of using the compounds and compositions.
    Type: Application
    Filed: June 25, 2004
    Publication date: April 7, 2005
    Applicant: Elan Pharmaceuticals, Inc.
    Inventors: Theodore Yednock, Stephen Freedman, Ivan Lieberburg, Michael Pleiss, Andrei Konradi, George Shopp, Elizabeth Messersmith
  • Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents
    Publication number: 20050069541
    Abstract: The application provides for methods and compositions for inhibiting demyelination, promoting remyelination and/or treating paralysis in a subject in need thereof. Preferably, such compositions include immunoglobulins (e.g., antibodies, antibody fragments, and recombinantly produced antibodies or fragments), polypeptides (e.g., soluble forms of the ligand proteins for integrins) and small molecules, which when administered in an effective amount inhibits demyelination and/or promotes remyelination in a patient. The compositions and methods described herein can also utilize other anti-inflammatory agents used to palliate conditions and diseases associated with demyelination.
    Type: Application
    Filed: January 26, 2004
    Publication date: March 31, 2005
    Inventors: Stephen Karlik, Michael Pleiss, Andrei Konradi, Francine Farouz, Christopher Semko, Darren Dressen, Elizabeth Messersmith, Stephen Freedman, Ted Yednock
  • Methods and compositions for treating rheumatoid arthritis
    Publication number: 20050065192
    Abstract: This application relates to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and an antibody to alpha-4 integrin or an immunologically active antigen binding fragment in therapeutically effective amounts. The application also relates generally to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and small molecule alpha-4 integrin antagonist that inhibits the alpha-4 integrin (?4 integrin) interaction with VCAM-1. The invention further relates to methods of preparing the compounds and methods of using the compounds and compositions.
    Type: Application
    Filed: June 25, 2004
    Publication date: March 24, 2005
    Applicant: Elan Pharmaceuticals, Inc.
    Inventors: Theodore Yednock, Stephen Freedman, Ivan Lieberburg, Michael Pleiss, Andrei Konradi, George Shopp, Elizabeth Messersmith