Patents by Inventor Andrei Manolescu

Andrei Manolescu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Genetic susceptibility variants associated with cardiovascular disease
    Patent number: 9617597
    Abstract: The invention relates to methods of diagnosing susceptibility to cardiovascular disease, including coronary artery disease. MI, abdominal aorta aneurysm, intracranial aneurysm restenosis and peripheral arterial disease, by assessing the presence or absence of alleles of certain polymorphic markers found to be associated with cardiovascular disease. The invention further relates to kits encompassing reagents for assessing such markers, and methods for assessing the probability of response to therapeutic agents and methods using such markers.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: April 11, 2017
    Assignee: deCode Genetics ehf
    Inventors: Anna Helgadottir, Gudmar Thorleifsson, Andrei Manolescu
  • GENETIC VARIANTS ON CHR 5P12 AND 10Q26 AS MARKERS FOR USE IN BREAST CANCER RISK ASSESSMENT, DIAGNOSIS, PROGNOSIS AND TREATMENT
    Publication number: 20140179546
    Abstract: The invention pertains to certain genetic variants on Chr5p12 and Chr10q26 as susceptibility variants of breast cancer. Methods of disease management, including diagnosing increased and/or decreased susceptibility to breast cancer, methods of predicting response to therapy and methods of predicting prognosis using such variants are described. The invention further relates to kits useful in the methods of the invention.
    Type: Application
    Filed: October 9, 2013
    Publication date: June 26, 2014
    Applicant: deCODE Genetics ehf.
    Inventors: Simon Stacey, Patrick Sulem, Andrei Manolescu
  • Genetic variants on chr 5p12 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment
    Patent number: 8580501
    Abstract: The invention pertains to certain genetic variants on Chr5p12 and Chr10q26 as susceptibility variants of breast cancer. Methods of disease management, including diagnosing increased and/or decreased susceptibility to breast cancer, methods of predicting response to therapy and methods of predicting prognosis using such variants are described. The invention further relates to kits useful in the methods of the invention.
    Type: Grant
    Filed: May 21, 2008
    Date of Patent: November 12, 2013
    Assignee: deCODE Genetics ehf.
    Inventors: Simon Stacey, Patrick Sulem, Andrei Manolescu
  • Fluorinated fructose derivatives for PET imaging
    Patent number: 8501154
    Abstract: The present invention is directed to fructose-based radiopharmaceuticals, pharmaceutical compositions comprising same, precursors and methods for preparing same, and methods of using same for diagnostic imaging of cancer cells and non-imaging tracer studies.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: August 6, 2013
    Assignee: The Governors of the University of Alberta
    Inventors: Chris Cheeseman, Frederick West, Tina Grant, Brendan Trayner, John Mercer, Andrei Manolescu
  • FLUORINATED FRUCTOSE DERIVATIVES FOR PET IMAGING
    Publication number: 20130078184
    Abstract: The present invention is directed to fructose-based radiopharmaceuticals, pharmaceutical compositions comprising same, precursors and methods for preparing same, and methods of using same for diagnostic imaging of cancer cells and non-imaging tracer studies.
    Type: Application
    Filed: September 19, 2012
    Publication date: March 28, 2013
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Chris CHEESEMAN, Frederick WEST, Tina GRANT, Brendan TRAYNER, John MERCER, Andrei MANOLESCU
  • Fluorinated fructose derivatives for PET imaging
    Patent number: 8293208
    Abstract: The present invention is directed to fructose-based radiopharmaceuticals, pharmaceutical compositions comprising same, precursors and methods for preparing same, and methods of using same for diagnostic imaging of cancer cells and non-imaging tracer studies.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: October 23, 2012
    Assignee: The Governors of the University of Alberta
    Inventors: Chris Cheeseman, Frederick West, Tina Grant, Brendan Trayner, John Mercer, Andrei Manolescu
  • GENETIC SUSCEPTIBILITY VARIANTS ASSOCIATED WITH CARDIOVASCULAR DISEASE
    Publication number: 20120208709
    Abstract: The invention relates to methods of diagnosing susceptibility to cardiovascular disease, including coronary artery disease, MI, abdominal aorta aneurysm, intracranial aneurysm restenosis and peripheral arterial disease, by assessing the presence or absence of alleles of certain polymorphic markers found to be associated with cardiovascular disease. The invention further relates to kits encompassing reagents for assessing such markers, and methods for assessing the probability of response to therapeutic agents and methods using such markers.
    Type: Application
    Filed: April 19, 2012
    Publication date: August 16, 2012
    Applicant: deCODE Genetics ehf.
    Inventors: Andrei Manolescu, Anna Helgadottir, Gudmar Thorleifsson
  • GENETIC VARIANTS ON CHR2 AND CHR16 AS MARKERS FOR USE IN BREAST CANCER RISK ASSESSMENT, DIAGNOSIS, PROGNOSIS AND TREATMENT
    Publication number: 20110117545
    Abstract: The invention pertains to certain genetic variants on Chr2q14, Chr2q35 and Chr16q12 as susceptibility variants of breast cancer. Methods of risk assessment and diagnosis of increased and/or decreased susceptibility to breast cancer, using such variants are described. The invention further relates to kits for diagnosing a susceptibility to breast cancer.
    Type: Application
    Filed: March 26, 2008
    Publication date: May 19, 2011
    Applicant: deCODE Genetics ehf
    Inventors: Simon Stacey, Patrick Sulem, Andrei Manolescu
  • Genetic Variants on chr 5p12 and 10q26 as Markers for Use in Breast Cancer Risk Assessment, Diagnosis, Prognosis and Treatment
    Publication number: 20110015081
    Abstract: The invention pertains to certain genetic variants on Chr5p12 and Chr10q26 as susceptibility variants of breast cancer. Methods of disease management, including diagnosing increased and/or decreased susceptibility to breast cancer, methods of predicting response to therapy and methods of predicting prognosis using such variants are described. The invention further relates to kits useful in the methods of the invention.
    Type: Application
    Filed: May 21, 2008
    Publication date: January 20, 2011
    Applicant: deCODE Genetics ehf.
    Inventors: Simon Stacey, Patrick Sulem, Andrei Manolescu
  • FLUORINATED FRUCTOSE DERIVATIVES FOR PET IMAGING
    Publication number: 20100290988
    Abstract: The present invention is directed to fructose-based radiopharmaceuticals, pharmaceutical compositions comprising same, precursors and methods for preparing same, and methods of using same for diagnostic imaging of cancer cells and non-imaging tracer studies.
    Type: Application
    Filed: May 15, 2009
    Publication date: November 18, 2010
    Inventors: Chris CHEESEMAN, Frederick WEST, Tina GRANT, Brendan TRAYNER, John MERCER, Andrei MANOLESCU
  • GENETIC SUSCEPTIBILITY VARIANTS ASSOCIATED WITH CARDIOVASCULAR DISEASE
    Publication number: 20100068705
    Abstract: The invention relates to methods of diagnosing susceptibility to cardiovascular disease, including coronary artery disease. MI, abdominal aorta aneurysm, intracranial aneurysm restenosis and peripheral arterial disease, by assessing the presence or absence of alleles of certain polymorphic markers found to be associates with cardiovascular disease. The invention further relates to kits encompassing reagents for assessing such markers, and methods for assessing the probability of response to therapeutic agents and methods using such markers.
    Type: Application
    Filed: February 21, 2008
    Publication date: March 18, 2010
    Applicant: deCode Genetics ehf
    Inventors: Anna Helgadottir, Gudmar Thorleifsson, Andrei Manolescu