Patents by Inventor Andrei Ogrel
Andrei Ogrel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9849173Abstract: The present disclosure provides methods for preparing vesicles. In some embodiments, the methods involve providing a molten mixture of vesicle forming lipids and then adding the molten mixture to an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. In other embodiments, the methods involve providing a lyophilized lipid product and rehydrating the lyophilized lipid product with an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. The lyophilized lipid product is prepared by melting vesicle-forming lipids to produce a molten lipid mixture and then lyophilizing the molten lipid mixture. The present disclosure also provides antigen-containing vesicle formulations prepared using these methods. The present disclosure also provides kits that include a lyophilized lipid product in a first container and an aqueous solution comprising an antigen in a second container.Type: GrantFiled: July 6, 2010Date of Patent: December 26, 2017Assignee: Variation Biotechnologies Inc.Inventors: David E. Anderson, Andrei Ogrel
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Patent number: 9610248Abstract: The present disclosure provides compositions and methods useful for treating influenza. As described herein, provided compositions and methods are based on the development of certain compositions that include an influenza virus hemagglutinin antigen in combination with lipid vesicles that include a non-ionic surfactant (NISVs) and optionally an adjuvant. In certain embodiments, provided compositions remain potent even when they are not stored in a standard cold-chain system (i.e., they are thermostable).Type: GrantFiled: July 6, 2011Date of Patent: April 4, 2017Assignee: Variation Biotechnologies, Inc.Inventors: David E. Anderson, Andrei Ogrel, Ronald Erwin Boch, Jeff Baxter
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Patent number: 9603920Abstract: The present application provides compositions and methods useful for treating influenza. As described herein, the compositions and methods are based on the development of peptides and peptide combinations which exhibit immunogenic properties against influenza. In some embodiments, the peptide combinations induce a protective response against multiple strains of influenza, e.g., seasonal strains of influenza or even the new pandemic influenza A (H1N1) virus of swine origin.Type: GrantFiled: January 23, 2014Date of Patent: March 28, 2017Assignee: Variation Biotechnologies, Inc.Inventors: Francisco Diaz-Mitoma, Andrei Ogrel, Jose V. Torres, David E. Anderson
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Publication number: 20140370041Abstract: The present application provides compositions and methods useful for treating influenza. As described herein, the compositions and methods are based on the development of peptides and peptide combinations which exhibit immunogenic properties against influenza. In some embodiments, the peptide combinations induce a protective response against multiple strains of influenza, e.g., seasonal strains of influenza or even the new pandemic influenza A (H1N1) virus of swine origin.Type: ApplicationFiled: January 23, 2014Publication date: December 18, 2014Applicant: Variation Biotechnologies, Inc.Inventors: Francisco Diaz-Mitoma, Andrei Ogrel, Jose V. Torres, David E. Anderson
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Publication number: 20130108692Abstract: The present disclosure provides compositions and methods useful for treating influenza. As described herein, provided compositions and methods are based on the development of certain compositions that include an influenza virus hemagglutinin antigen in combination with lipid vesicles that include a non-ionic surfactant (NISVs) and optionally an adjuvant. In certain embodiments, provided compositions remain potent even when they are not stored in a standard cold-chain system (i.e., they are thermostable).Type: ApplicationFiled: July 6, 2011Publication date: May 2, 2013Applicant: VARIATION BIOTECHNOLOGIES, INC.Inventors: David E. Anderson, Andrei Ogrel, Ronald Erwin Boch, Jeff Baxter
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Publication number: 20120156240Abstract: The present disclosure provides methods for preparing vesicles. In some embodiments, the methods involve providing a molten mixture of vesicle forming lipids and then adding the molten mixture to an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. In other embodiments, the methods involve providing a lyophilized lipid product and rehydrating the lyophilized lipid product with an aqueous solution comprising an antigen such that antigen-containing vesicles are formed. The lyophilized lipid product is prepared by melting vesicle-forming lipids to produce a molten lipid mixture and then lyophilizing the molten lipid mixture. The present disclosure also provides antigen-containing vesicle formulations prepared using these methods. The present disclosure also provides kits that include a lyophilized lipid product in a first container and an aqueous solution comprising an antigen in a second container.Type: ApplicationFiled: July 6, 2010Publication date: June 21, 2012Applicant: VARIATION BIOTECHNOLOGIES, INC.Inventors: David E. Anderson, Andrei Ogrel
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Publication number: 20110097418Abstract: The present application provides compositions and methods useful for treating influenza. As described herein, the compositions and methods are based on the development of peptides and peptide combinations which exhibit immunogenic properties against influenza. In some embodiments, the peptide combinations induce a protective response against multiple strains of influenza, e.g., seasonal strains of influenza or even the new pandemic influenza A (H1N1) virus of swine origin.Type: ApplicationFiled: June 19, 2009Publication date: April 28, 2011Applicant: VARIATION BIOTECHNOLOGIES, INC.Inventors: Francisco Diaz-Mitoma, Andrei Ogrel, Jose V. Torres, David E. Anderson
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Publication number: 20110020381Abstract: Peptide-based anti-influenza formulations against influenza are disclosed. The peptides are derived from influenza-based epitopes. The formulations are based on peptide mixtures which may be formulated so that variability is present at particular residues. The formulations can be used to prepare vaccines for preventing influenza, particularly avian influenza.Type: ApplicationFiled: September 3, 2010Publication date: January 27, 2011Applicant: VARIATION BIOTECHNOLOGIES INC.Inventor: Andrei OGREL
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Patent number: 7807173Abstract: Peptide-based anti-influenza formulations against influenza are disclosed. The peptides are derived from influenza-based epitopes. The formulations are based on peptide mixtures which may be formulated so that variability is present at particular residues. The formulations can be used to prepare vaccines for preventing influenza, particularly avian influenza.Type: GrantFiled: November 30, 2007Date of Patent: October 5, 2010Assignee: Variation Biotechnologies Inc.Inventor: Andrei Ogrel
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Publication number: 20080193472Abstract: Peptide-based anti-influenza formulations against influenza are disclosed. The peptides are derived from influenza-based epitopes. The formulations are based on peptide mixtures which may be formulated so that variability is present at particular residues. The formulations can be used to prepare vaccines for preventing influenza, particularly avian influenza.Type: ApplicationFiled: November 30, 2007Publication date: August 14, 2008Applicant: VARIATION BIOTECHNOLOGIES INC.Inventor: Andrei Ogrel