Patents by Inventor Andrei P. Guzzaev

Andrei P. Guzzaev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleosidic and non-nucleosidic folate conjugates
    Patent number: 6861514
    Abstract: Oligonucleotide-folate conjugates are described wherein folates are conjugated to one or more sites on an oligonucleotide including the 2?-, 3?-, 5?-, nucleobase and internucleotide linkage sites. The folate can be attached via the ?- or ?-carboxylate, optionally through a linking group. Methods for the regiospecific synthesis of the conjugates are disclosed. Also disclosed are nucleosidic and non-nucleosidic linkers conjugated to folic acid and related folates.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: March 1, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Muthiah Manoharan, Balkrishen Bhat, Andrei P. Guzzaev