Patents by Inventor Andrej Smiyakin

Andrej Smiyakin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the generation of a cell composition ventral midbrain patterned dopaminergic progenitor cells
    Patent number: 11866729
    Abstract: The present invention discloses an in vitro method for the generation of a cell composition comprising or consisting of ventral midbrain dopaminergic progenitor cells from a cell composition comprising pluripotent and/or multipotent stem cells, the method comprising the steps of A) differentiating said pluripotent and/or multipotent stem cells into ventral dopaminergic progenitor cells, thereby generating a cell composition comprising ventral dopaminergic progenitor cells comprising ventral midbrain dopaminergic progenitor cells and ventral hindbrain dopaminergic progenitor cells, and B) Enriching CD117 positive cells from said cell composition comprising ventral dopaminergic progenitor cells by using an antigen binding molecule specific for the CD117 antigen, thereby generating said cell composition comprising or consisting of ventral midbrain dopaminergic progenitor cells. Cell compositions obtainable by said method are also disclosed.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: January 9, 2024
    Assignee: MILTENYI BIOTEC B.V. & CO. KG
    Inventors: Andreas Bosio, Andrej Smiyakin
  • METHOD FOR THE GENERATION OF A CELL COMPOSITION VENTRAL MIDBRAIN DOPAMINERGIC PROGENITOR CELLS
    Publication number: 20210079344
    Abstract: The present invention discloses an in vitro method for the generation of a cell composition comprising or consisting of ventral midbrain dopaminergic progenitor cells from a cell composition comprising pluripotent and/or multipotent stem cells, the method comprising the steps of A) differentiating said pluripotent and/or multipotent stem cells into ventral dopaminergic progenitor cells, thereby generating a cell composition comprising ventral dopaminergic progenitor cells comprising ventral midbrain dopaminergic progenitor cells and ventral hindbrain dopaminergic progenitor cells, and B) Enriching CD117 positive cells from said cell composition comprising ventral dopaminergic progenitor cells by using an antigen binding molecule specific for the CD117 antigen, thereby generating said cell composition comprising or consisting of ventral midbrain dopaminergic progenitor cells. Cell compositions obtainable by said method are also disclosed.
    Type: Application
    Filed: September 3, 2020
    Publication date: March 18, 2021
    Applicant: Miltenyi Biotec B.V. & Co. KG
    Inventors: Andreas Bosio, Andrej Smiyakin