Abstract: A method for forming a structural tile for use in a composite panel includes providing a base plate of a compression mold assembly. The method also includes placing a grid structure mold of the compression mold assembly atop the base plate. The grid structure mold defines a cavity having a desired shape for a grid structure. Further, the method includes filling the cavity of the grid structure mold with a plurality of fragments of recycled fiber reinforced polymer material. Moreover, the method includes placing a cover plate of the compression mold assembly atop the grid structure mold to apply pressure to the grid structure mold. The method also includes applying heat to the cover plate to heat the plurality of fragments of recycled fiber reinforced polymer material such that the recycled fiber reinforced polymer material melts within the cavity. In addition, the method includes allowing the melted recycled fiber reinforced polymer material to cure to form the structural tile.

Abstract: A system for an agricultural harvester can include one or more processors and one or more non-transitory computer-readable media. The one or more non-transitory computer-readable media collectively store a machine-learned model configured to receive data associated with one or more harvest-related conditions for an agricultural harvester and process the data to determine a first harvest-related parameter associated with an infeed volume of harvest material for the agricultural harvester and instructions that, when executed by the one or more processors, configure the computing system to perform operations. The operations can include obtaining the data associated with one or more harvest-related conditions, inputting the data into the machine-learned model, and receiving a first value for the harvest-related parameter as a first output of the machine-learned model.

Abstract: A system for an agricultural harvester includes one or more processors and one or more non-transitory computer-readable media that stores a machine-learned mass estimation model configured to receive data associated with one or more operation-related conditions for an agricultural harvester and process the data to determine an output indicative of a stalk mass for the agricultural harvester. The one or more non-transitory computer-readable media also stores instructions that, when executed by the one or more processors, configure the computing system to perform operations. The operations include obtaining the data associated with one or more operation-related conditions; inputting the data into the machine-learned mass estimation model; and receiving a value for the stalk mass as the output of the machine-learned mass estimation model for a defined time period.

Abstract: A system for an agricultural harvester includes a chopper assembly configured to separate a harvested material into debris and stalk. A primary extractor is configured to remove debris from the harvester. A sensor system is configured to capture data associated with harvested material conditions downstream of the primary extractor. A computing system includes one or more processors and one or more non-transitory computer-readable media that collectively store instructions that, when executed by the one or more processors, configure the computing system to perform operations. The operations include obtaining the data associated with the associated harvested material conditions downstream of the primary extractor, determining a current foliage ratio based on the data, determining an error between the current foliage ratio to a desired foliage ratio, and generating a harvest-related parameter of the primary extractor based at least in part on the error.

Abstract: Provided are a class of compounds, represented by formula (I??), as selective EGFR inhibitors, a pharmaceutical composition containing the compounds, useful intermediates for preparing the compounds, and a method for using the compounds of the present invention to treat cell proliferative diseases, such as cancers.

Abstract: A method for assembling a shell section of a wind turbine blade includes providing a support, the support comprising a surface having a primary surface portion configured for supporting a first component and a secondary surface portion configured for supporting a second component. The method also includes arranging a second component on the secondary surface portion such that an outer surface of the second component is facing the secondary surface portion. The method further includes arranging a first component on the primary surface portion such that an outer surface of the first component is facing the primary surface portion, and such that a first primary joint surface of the first component is facing a second joint surface of the second component. Arranging the first component includes applying a force to the first component to force the outer surface of the first component towards the primary surface portion and the first primary joint surface towards the second joint surface.

Abstract: The present disclosure is directed to an apparatus for manufacturing a composite component. The apparatus includes a mold onto which the composite component is formed. The mold is disposed within a grid defined by a first axis and a second axis. The apparatus further includes a first frame assembly disposed above the mold, and a plurality of printheads coupled to the first frame assembly within the grid in an adjacent arrangement along the first axis. At least one of the mold or the plurality of printheads is moveable along the first axis, the second axis, or both. At least one of the printheads of the plurality of printheads is moveable independently of one another along a third axis.

Abstract: The present invention provides a novel aminopyrimidine compound as a fourth-generation EGFR (T790M/C797S mutation) selective inhibitor, a pharmaceutical composition comprising the compound, an intermediate useful for preparing the compound, and a method for treating a cell proliferative disease, such as a cancer, by using the compound of the present invention.

Abstract: Provided are a class of compounds, represented by formula (I??), as selective EGFR inhibitors, a pharmaceutical composition containing the compounds, useful intermediates for preparing the compounds, and a method for using the compounds of the present invention to treat cell proliferative diseases, such as cancers.

Abstract: The disclosure relates to a method of manufacturing a fibre reinforced composite, wherein the surface of the fibre reinforced composite modified by using a laser radiation. In particular, the pre-treatment is performed before a bonding process. Time-consuming and dust generating grinding of the surface can be avoided.

Abstract: A method for assembling a shell section of a wind turbine blade includes providing a support, the support comprising a surface having a primary surface portion configured for supporting a first component and a secondary surface portion configured for supporting a second component. The method also includes arranging a second component on the secondary surface portion such that an outer surface of the second component is facing the secondary surface portion. The method further includes arranging a first component on the primary surface portion such that an outer surface of the first component is facing the primary surface portion, and such that a first primary joint surface of the first component is facing a second joint surface of the second component. Arranging the first component includes applying a force to the first component to force the outer surface of the first component towards the primary surface portion and the first primary joint surface towards the second joint surface.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins that are degraded and/or otherwise inhibited by bifunctional compounds of the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand that binds to the ubiquitin ligase and on the other end a moiety that binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds of the present invention, consistent with the degradation/inhibition of targeted polypeptides.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: A compound of formula (I): or a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of the estrogen receptor, including degrading the estrogen receptor, the treatment of diseases and conditions mediated by the estrogen receptor.

Abstract: A compound of formula (I): or a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of the estrogen receptor, including degrading the estrogen receptor, the treatment of diseases and conditions mediated by the estrogen receptor.