Abstract: A sine wave generator includes a resonator circuit, a control circuit and a pulse generator. The resonator circuit is configured to receive energy pulses and to generate a resonator sinusoidal signal responsively to the energy pulses. The control circuit is configured to estimate a signal measure of the resonator sinusoidal signal, or of a signal derived from the resonator sinusoidal signal. The pulse generator is configured to generate the energy pulses responsive to the signal measure estimated by the control circuit, and to drive the resonator circuit with the energy pulses.

Abstract: Apparatus, consisting of a probe with a temperature sensor and a transducer in contact with a living subject's tissue. A power supply delivers electrical power to the transducer for tissue ablation. A controller receives a signal from the temperature sensor and in response outputs a tissue temperature. During a first time period the power supply delivers no more than a first target power to the transducer, and reduces the power when a first maximum allowable temperature of the tissue is exceeded. During a transition time period the power supply delivers no more than a second target power, while reducing the delivered power when the first maximum allowable temperature of the tissue is exceeded. During a second time period the power supply delivers no more than the second target power, while reducing the delivered power when a second maximum allowable temperature, less than the first maximum allowable temperature, is exceeded.

Abstract: A medical probe includes a shaft and an expandable flexible distal-end assembly. The shaft is configured for insertion into a cavity of organ of a patient. The expandable flexible distal-end assembly, which is fitted at a distal-end of the shaft, includes a flat flexible backing sheet, including irrigation channels, and two flexible substrates having respective arrays of electrodes disposed thereon, the substrates attached one on either side of the backing sheet.

Abstract: Catheterization is carried out by bringing an electrode that is disposed on a distal portion of a catheter into contact with tissue, wherein the electrode has an area that falls within a range of 0.01-25 mm2. A power generator delivers pulses of radiofrequency power through the electrode to the tissue. While applying the pulses temperatures at the distal portion of the catheter are recorded. A rate of change of the temperatures is calculated and tissue thickness estimated based on the rate of change.

Abstract: A medical apparatus includes a probe, which includes an insertion tube configured for insertion into a body cavity of a patient and a basket assembly connected distally to the insertion tube and including a plurality of resilient, conductive spines, which are configured to contact tissue within the body. The apparatus further includes an electrical signal generator configured to apply between one or more pairs of the spines bipolar pulses having an amplitude sufficient to cause irreversible electroporation (IRE) in the tissue contacted by the spines.

Abstract: An apparatus includes a processor and an output device. The processor is configured to receive positions, within a heart of a patient, of one or more electrodes that apply Radio Frequency (RF) energy to ablate tissue in the heart, in a coordinate system having a vertical axis. The processor is further configured to receive positions, within a heart of a patient, of one or more electrodes that apply Radio Frequency (RF) energy to ablate tissue in the heart, in a coordinate system having a vertical axis, and to calculate, based on the received positions, a subset of one or more smallest heights among respective heights of the electrodes above an esophagus of the patient along the vertical axis, and to generate a graphical user interface that visualizes the electrodes and the respective heights above the esophagus. The output device is configured to present the graphical user interface to a user.

Abstract: An apparatus includes an interface and a processor. The interface is configured to receive one or more magnetic-positioning signals from one or more position sensors coupled to one or more body-surface patches attached to a body of a patient, the magnetic-positioning signals indicative of respective positions of the position sensors. The processor is configured to (i) detect an inadvertent stimulation of a phrenic nerve of the patient, which occurs due to cardiac pacing applied by an intra-cardiac electrode in a heart of the patient, (ii) estimate, based on the magnetic-positioning signals, a motion of one or more of the body-surface patches occurring during the detected stimulation of the phrenic nerve, (iii) estimate, based on the estimated motion of the body-surface patches, a distance between the pacing electrode and the phrenic nerve, and (iv) send an output derived from the estimated distance to the output device.

Abstract: A method for estimating a thickness of cardiac tissue undergoing ablation includes the steps of (a) applying a sequence of ablation pulses to a region of the cardiac tissue, so as to create a lesion, and (b) for a given ablation pulse in the sequence, an incremental depth added to the lesion due to the given ablation pulse is estimated. A cumulative depth of the lesion is estimated based on the cumulative depth prior to the given pulse, and on the incremental depth. An amplitude of an electrogram signal at the region is assessed after applying the given ablation pulse, and, if the amplitude exceeds a predefined threshold, an estimate of the thickness is set to be at least the cumulative depth.

Abstract: A sine wave generator includes a resonator circuit, a control circuit and a pulse generator. The resonator circuit is configured to receive energy pulses and to generate a resonator sinusoidal signal responsively to the energy pulses. The control circuit is configured to estimate a signal measure of the resonator sinusoidal signal, or of a signal derived from the resonator sinusoidal signal. The pulse generator is configured to generate the energy pulses responsive to the signal measure estimated by the control circuit, and to drive the resonator circuit with the energy pulses.

Abstract: Apparatus, consisting of a probe configured to be inserted into contact with a myocardium, and an electrode attached to the probe. A temperature sensor, incorporated in the probe, is configured to output a temperature signal. A pump irrigates the myocardium, via the probe, with an irrigation fluid at a controllable rate, and a radiofrequency (RF) signal generator applies RF power via the electrode to the myocardium, so as to ablate the myocardium. The apparatus also has processing circuitry that measures a temperature of the probe, based on the temperature signal, while the RF power is applied and, when the measured temperature exceeds a preset target temperature, iteratively reduces the RF power applied by the signal generator and concurrently iteratively varies a rate of irrigation of the irrigation fluid provided by the pump, until the measured temperature is reduced to the preset target temperature.

Abstract: A medical apparatus includes a probe configured for insertion into a body of a patient and comprising an array of electrodes disposed along the probe and configured to contact tissue within the body. An electrical signal generator applies sequences of bipolar pulses over one or more trios of the electrodes, each trio including first, second and third neighboring electrodes, such that the second electrode is disposed between and adjacent to the first and third electrodes. While the probe contacts the tissue, the electrical signal generator applies the sequences of the bipolar pulses between the first and second electrodes during one or more first time intervals, and between the second and third electrodes during one or more second time intervals, and between the first and third electrodes during one or more third time intervals, wherein the first, second and third time intervals are mutually disjointed.

Abstract: A method, including receiving, from electrodes positioned within a heart, first signals from at least three of the electrodes indicating electrical activity in tissue with which the at least three of the electrodes engage, and second signals indicating locations of the at least three electrodes. The second signals are processed to compute the locations of the at least three electrodes and to determine a geometric center of the locations. Based on the signals, an electroanatomical map is generated for an area of the tissue including the geometric center, and an arrhythmia focus is determined in the map. A circle is presented, and within the circle, a region of the map is presented including the geometric center and the focus so that the geometric center on the map aligns with a center of the circle, the region within the circle indicating a spatial relationship between the geometric center and the focus.

Abstract: Physicians performing invasive procedures require accuracy and precision when working with surgical tools. Surgical procedures are increasingly becoming minimally invasive, with physicians operating using cameras to view the surgery site and directing their tools through oculars or video displays. Ideally, the physician should be able to perform the invasive procedure while simultaneously observing both the real-time image of the patient and additional data critical for his medical decisions about the manipulation of the surgical tool and the next surgical step. The augmented reality navigation system of the present disclosure provides tool location visibility for invasive procedures through the use of location sensors included on a camera and/or on the tools used during a procedure. A location tracking system determines and monitors the locations of the tools and camera based on the characteristics of signals detected by the sensors and displays informational overlays on images obtained with a camera.

Abstract: A medical probe includes a shaft and a frame. The shaft is configured for insertion into an organ of a patient. The frame is coupled to a distal end of the shaft, and includes (i) a plurality of electrodes disposed on an outer surface of the frame and configured to apply irreversible electroporation (IRE) to tissue by applying voltage pulses, and (ii) one or more irrigation channels, configured to flow irrigation fluid in a vicinity of the electrodes.

Abstract: A trocar for insertion into an organ of a patient includes a cannula having a distal opening, a channel inside the cannula, and an optical assembly including a camera. The optical assembly is disposed at a distal end of the channel and is configured to provide camera images of the distal opening with a field-of-view (FOV) that is tilted relative to a longitudinal axis of the cannula.

Abstract: An electrical apparatus includes a spiral electrode and an interface circuit. The spiral electrode is disposed on a distal end of a probe for insertion into a body of a patient. The interface circuit is configured to (a) transfer a radiofrequency (RF) ablation signal to the electrode for ablating tissue in the body, (b) output a voltage that develops across the electrode in response to an external magnetic field, for measuring a position of the distal end in the body, and (c) transfer electrical current through the electrode for measuring a resistivity that is indicative of tissue temperature in a vicinity of the electrode.

Abstract: A method includes, using a probe, applying irreversible electroporation (IRE) pulses to tissue over a time period to form a lesion in the tissue. A contact force applied to the tissue by the probe is measured over the time period. An IRE index is calculated based on the measured contact force and on a power level of the IRE pulses. Application of the IRE pulses to the tissue is ceased in response to the calculated IRE index reaching a prespecified target IRE index value.

Abstract: A cardiac pacing and irreversible electroporation (IRE) apparatus includes a pulse generator and a shaping circuit. The pulse generator is configured to generate IRE pulses of prespecified shape and repetition rate. The shaping circuit is configured to convert some of the IRE pulses into pacing pulses of prespecified frequency and amplitude, to generate an output signal including ones of the IRE pulses interleaved with ones of the pacing pulses, and to output the output signal to a probe in a heart of a patient for applying the output signal to cardiac tissue.

Abstract: A medical apparatus includes a probe configured for insertion into a body of a patient and including a plurality of electrodes configured to contact tissue within the body. An electrical signal generator applies bipolar trains of pulses having a voltage amplitude of at least 200 V and having a duration of each of the bipolar pulses less than 20 ?s between at least one pair of the electrodes in contact with the tissue, thereby causing irreversible electroporation of the tissue between the at least one pair of the electrodes. One or more electrical sensors sense an energy dissipated between the at least one pair of the electrodes during the trains of the pulses. A controller controls electrical and temporal parameters of the trains of the pulses applied by the electrical signal generator, responsively to the one or more electrical sensors, so that the dissipated energy satisfies a predefined criterion.

Abstract: Methods, apparatus, and systems for medical procedures are disclosed herein and include receiving, at a location agnostic system and at a first time, a first plurality of electronic signals each from a respective plurality of electrodes of a catheter. A subset of electronic signals of the first plurality of electronic signals may be received at a location aware system. The location aware system may determine a location of the catheter within an intra-body organ. The location aware system may determine that the catheter is in contact with the tissue at the location, based on the subset of electronic signals and at least one tissue property at the location. A location agnostic system contact profile for the catheter may be generated based on determining, by the location aware system, that the catheter is in contact with the tissue at the location.