Abstract: Mouse genes differentially expressed in comparisons of normal vs. hyperinsulinemic, hyperinsulinemic vs. type 2 diabetic, and normal vs. type 2 diabetic liver by gene chip analysis have been identified, as have corresponding human genes and proteins. The human molecules, or antagonists thereof, may be used for protection against hyperinsulinemia or type 2 diabetes, or their sequelae.

Abstract: Mouse genes differentially expressed in comparisons of older and younger livers by gene chip analysis have been identified, as have corresponding human genes and proteins. The human molecules, or antagonists thereof, may be used for protection against faster-than-normal biological aging, or to achieve slower-than-normal biological aging. The human molecules may also be used as markers of biological aging.

Abstract: We disclose a method for the correlation of structural feature information derived from digital images of a diagnostic set of histopathological tissue specimens from a group of subjects with shared characteristics and molecular activity (which may be either gene or protein expression) information derived from related specimens of the same set to provide for the objective characterization and analysis of the variability of tissue structural features in relation to such molecular activity (the product of such correlation referred to herein as the “correlated tissue information”). Such correlated tissue information allows for comparison and combination with correlated tissue information obtained through studies taking place at different times, with different protocols for the collection, preservation, histological staining and molecular activity assays of the tissue.