Abstract: Systems and methods for flight plan validation and automated route improvement include obtaining flight plan data descriptive of a first plurality of planned flights; obtaining route data describing one or more preconfigured routes; selecting, for each of the first plurality of planned flights, a set of viable routes from the route data; obtaining validation data associated with each viable route for each planned flight of the first plurality of planned flights; based on a determination that no route of the set of viable routes is valid, communicating a request to a route identification service; receiving validated route data describing one or more validated routes associated with the planned flight; and generating a visual indication of a set of confirmed routes for the planned flight.

Abstract: The present invention relates to an organic matter biodigester comprising a tank that has an organic matter inlet, a first connection arranged in an upper portion of the tank and a second connection arranged in the lower portion of the tank. Furthermore, said tank also has a biogas outlet and a lower surface configured to rest on a support surface. Furthermore, the lower portion of the tank is at a shorter distance from the support surface compared to the upper portion of the tank. Said organic matter biodigester also comprises a manual pump with a pump inlet connected in the second connection, and a pump outlet connected in the first connection of the tank. The pump is configured to recirculate the organic matter inside the tank from the second connection towards the first connection; and a porous layer arranged inside the tank.

Abstract: An ultrasonic imaging system is disclosed. The ultrasonic imaging system comprises an ultrasonic catheter having a longitudinal axis, a proximal end, and a distal end. The ultrasonic imaging system includes an ultrasonic transducer array disposed within the distal end of the ultrasonic catheter. The ultrasonic transducer array comprises a plurality of transducer array elements arranged on a substrate. Further, a catheter shaft is connected at one end to a handle assembly and at other end to the ultrasonic transducer array. The catheter shaft houses an electronic flex cable which is in communication with at least one signal trace and is configured to direct each of the plurality of transducer array elements to transmit and receive ultrasound beams, receive at least one signal from the plurality of transducer array elements, and construct at least one image of at least a portion of the heart based on the at least one signal.

Abstract: A container for shipping chairs includes a floor and first and second side walls having bottoms hingedly connected to opposite sides of the floor. First and second holders configured to engage the bottom of first and second chairs, and first and second mounting members are disposed on the first and second side walls. First and second straps extend between the first and second mounting members and the first and second chairs.

Abstract: An ultrasonic imaging system is disclosed. The ultrasonic imaging system comprises an ultrasonic catheter having a longitudinal axis, a proximal end, and a distal end. The ultrasonic imaging system includes an ultrasonic transducer array disposed within the distal end of the ultrasonic catheter. The ultrasonic transducer array comprises a plurality of transducer array elements arranged on a substrate. Further, a catheter shaft is connected at one end to a handle assembly and at other end to the ultrasonic transducer array. The catheter shaft houses an electronic flex cable which is in communication with at least one signal trace, and is configured to direct each of the plurality of transducer array elements to transmit and receive ultrasound beams, receive at least one signal from the plurality of transducer array elements, and construct at least one image of at least a portion of the heart based on the at least one signal.

Abstract: An ultrasonic imaging system is disclosed. The ultrasonic imaging system comprises an Intracardiac echocardiographic (ICE) catheter and a transducer ring. A steerable sheath integrated with a built-in forward looking transducer and the transducer ring positioned at a distal end of the steerable sheath. The transducer ring comprises a MEMS based pMUT array arranged over a substrate. A catheter shaft houses a lumen to allow a passage of a puncture needle and an electronic flex cable in communication with at least one signal trace, configured to: direct the MEMS based pMUT array, via the at least one signal trace, to transmit and receive, ultrasound beams; receive at least one signal from the MEMS based pMUT array based on transmitting and receiving at least one ultrasound beam; and construct at least one image of at least a portion of the heart based on the at least one signal.

Abstract: An ICE imaging system is disclosed, which comprises an Intracardiac echocardiography (ICE) catheter having a longitudinal axis, a proximal end, and a distal end. The ICE catheter corresponds to a micro-electromechanical (MEMS) or other transducer based phased array ultrasound catheter with an out diameter of 6 French or smaller for delivery through an internal jugular, subclavian, axillary, innominate venous system into heart chambers for the purpose of lead placement for a pacemaker or other implantable cardioverter defibrillator (ICD) device. Further, a catheter shaft houses an electronic flex cable which is in communication with at least one signal trace, and is configured to direct a plurality of transducer array elements to transmit and receive ultrasound beams, receive at least one signal from the plurality of transducer array elements, and construct at least one image of at least a portion of the heart based on the at least one signal.

Abstract: An integrated cardiac mapping and Piezoelectric Micromachined Ultrasonic Transducer (pMUT) ultrasonic imaging system, is disclosed. The system comprising a pMUT imaging and mapping catheter having a longitudinal axis, a proximal end, and a distal end. A micro-electromechanical (MEMS) based pMUT or other transducer disposed within the distal end of the pMUT imaging and mapping catheter. A pMUT mapping array disposed within the distal end of the pMUT imaging and mapping catheter, wherein the mapping array comprises an expandable basket, grid, hoop, or other configuration with an electronic sensor array arranged on electronic flex circuits.

Abstract: An integrated ultrasonic imaging and ablation system is disclosed. The system comprising an ablation catheter having a longitudinal axis, a proximal end, and a distal end. A micro-electromechanical (MEMS) based Piezoelectric Micromachined Ultrasonic Transducer (pMUT) or other ultrasound transducer disposed within the distal end of the ablation catheter. A catheter shaft is connected at one end to a handle assembly and at other end to the MEMS based pMUT array. A first carrier assembly is coupled to the catheter shaft and having a first array of electrodes coupled to a plurality of first carrier arms. A second carrier assembly is coupled to the catheter shaft and having a second array of electrodes coupled to a plurality of second carrier arms.

Abstract: A pMUT guided ultrasound bronchoscope is disclosed. The pMUT guided ultrasound bronchoscope comprises an insertion tube having a proximal section and a distal section. A handle is connected to the proximal section, and a distal tip connected to the distal section of the insertion tube. The handle comprises a working channel entry port for inserting fluids and biopsy tools into a working channel extending through the insertion tube and exiting near the distal tip. A suction button is configured to control a valve disposed adjacent to the suction port for controlling suction when connected to a suction device.

Abstract: Provided herein are compositions, methods, and uses involving bispecific binding molecules that specifically bind to HER2, a receptor tyrosine kinase, and to CD3, a T cell receptor, and mediate T cell cytotoxicity for managing and treating disorders, such as cancer. Also provided herein are uses and methods for managing and treating HER2-related cancers.

Abstract: An ultrasonic catheter is disclosed. The ultrasonic catheter comprises a micro-electromechanical (MEMS) based Piezoelectric Micromachined Ultrasonic Transducer (pMUT) array disposed within a distal end of a body. The ultrasonic catheter further comprises a plurality of electronic flex circuits, connected at one end to a handle connector and at other end to a first layer of AIC. The handle connector passes ultrasound signals to the distal end via the plurality of electronic flex circuits. Further, a distal pMUT interposer is disposed between the first layer and a second layer of AIC, with InvisiVia connections. The InvisiVia connection is configured to bring the electronic flex circuit from one side of the distal pMUT interposer to the other. Further, the MEMS based pMUT array sends a pressure wave and receives a returning pressure wave echo via the InvisiVia connections of the distal pMUT interposer.

Abstract: An integrated ultrasonic imaging and ablation system is disclosed. The system comprising an ablation catheter having a longitudinal axis, a proximal end, and a distal end. A micro-electromechanical (MEMS) based Piezoelectric Micromachined Ultrasonic Transducer (pMUT) or other ultrasound transducer disposed within the distal end of the ablation catheter. A catheter shaft is connected at one end to a handle assembly and at other end to the MEMS based pMUT array. A first carrier assembly is coupled to the catheter shaft and having a first array of electrodes coupled to a plurality of first carrier arms. A second carrier assembly is coupled to the catheter shaft and having a second array of electrodes coupled to a plurality of second carrier arms.

Abstract: An ultrasonic catheter is disclosed. The ultrasonic catheter comprises a body having a longitudinal axis and a distal end. A Piezoelectric Micromachined Ultrasonic Transducer (pMUT) array is disposed within the distal end of the body. Further, the pMUT array comprises a plurality of pMUT array elements arranged on a substrate. Further, an insulating material is disposed at the distal end over an imaging window, to provide electrical isolation and transmission of ultrasound signals. The insulating material corresponds to a polyether block amide (PEBA) or Pebax, or thermoplastic elastomer (TPE).

Abstract: An ultrasonic catheter is disclosed. The ultrasonic catheter comprises a body having a longitudinal axis and a distal end. A Piezoelectric Micromachined Ultrasonic Transducer (pMUT) array is disposed within the distal end of the body. Further, the pMUT array comprises a plurality of pMUT array elements arranged on a substrate. Further, an insulating material is disposed at the distal end over an imaging window, to provide electrical isolation and transmission of ultrasound signals. The insulating material corresponds to a polyether block amide (PEBA) or Pebax, or thermoplastic elastomer (TPE).

Abstract: An ultrasonic imaging system is disclosed. The ultrasonic imaging system comprises an ultrasonic catheter having a longitudinal axis, a proximal end, and a distal end. The ultrasonic imaging system includes an ultrasonic transducer array disposed within the distal end of the ultrasonic catheter. The ultrasonic transducer array comprises a plurality of transducer array elements arranged on a substrate. Further, a catheter shaft is connected at one end to a handle assembly and at other end to the ultrasonic transducer array. The catheter shaft houses an electronic flex cable which is in communication with at least one signal trace, and is configured to direct each of the plurality of transducer array elements to transmit and receive ultrasound beams, receive at least one signal from the plurality of transducer array elements, and construct at least one image of at least a portion of the heart based on the at least one signal.

Abstract: A method for encrypting data, comprising: the transformation of a base message into an intermediate message by means of successive matrix rearrangement operations; the definition of a numerical set, which is transformed into a new numerical order, also by means of matrix rearrangement operations; the definition of a substitution alphabet; the establishment of a replacement operation, comprising the replacement of one character of the intermediate message by one character of the substitution alphabet, pursuant to a command defined by the new numerical order, starting from an initial magnitude of displacement, and progressively increasing the magnitude of displacement.

Abstract: Provided herein are compositions, methods, and uses involving bispecific binding molecules that specifically bind to HER2, a receptor tyrosine kinase, and to CD3, a T cell receptor, and mediate T cell cytotoxicity for managing and treating disorders, such as cancer. Also provided herein are uses and methods for managing and treating HER2-related cancers.

Abstract: A set including a plug connectable LED and a packaged photocurable composition. It relates also to methods for applying that article. The photocurable composition includes cyanoacrylate monomers and/or acrylate monomers, and a visible light photoinitiator system. The plug connectable LED, when connected to a host mobile device including a rechargeable battery, allows energisation of the LED so that it can be used as a convenient light source to cure the photocurable composition. The set itself does not comprise a battery or, batteries. The set is a versatile consumer product in the field of adhesives, fillers, sealants and coatings.

Abstract: An apparatus for controlling the rate of flow of mold material to a mold cavity, the apparatus comprising: an injection molding machine and a manifold; an actuator interconnected to a valve pin having a tip end; a valve system in fluid communication with the actuator to drive the actuator at one or more rates of travel, the valve system having a start position, one or more intermediate drive rate positions and a high drive rate position, the start position holding the valve pin in a gate closed position; a controller that instructs the valve system to move from the start position to the one or more intermediate drive rate positions and to remain in the one or more intermediate drive rate positions for one or more corresponding predetermined amounts of time.