Abstract: Systems and methods for automatically verifying that power relays have been disconnected include relays arranged between two power sources. Test nodes are positioned between the relays on each line, and feed into a detection circuit. Voltage drop resistors, voltage drop diodes, an optocoupler, and additional resistors and capacitors are used to provide voltage isolation for the detection circuit. Relays are methodically opened and closed to check the individual functioning of each relay, and a digital signal generated from the detection circuit. The design of the system with detection circuit isolation provides a safer and lower cost system for verifying that relays are operating correctly, with less costly components than traditional systems.

Abstract: Disclosed herein is a pallet that includes a top deck and a support section. The top deck includes a first frame portion and an encasement encasing the first frame portion. The support section includes a second frame portion connected to the first frame portion of the top deck.

Abstract: Systems and methods for automatically verifying that power relays have been disconnected include relays arranged between two power sources. Test nodes are positioned between the relays on each line, and feed into a detection circuit. Voltage drop resistors, voltage drop diodes, an optocoupler, and additional resistors and capacitors are used to provide voltage isolation for the detection circuit. Relays are methodically opened and closed to check the individual functioning of each relay, and a digital signal generated from the detection circuit. The design of the system with detection circuit isolation provides a safer and lower cost system for verifying that relays are operating correctly, with less costly components than traditional systems.

Abstract: The disclosure relates to a compound of the formula (I) and the use of such compounds.

Abstract: Systems and methods for automatically verifying that power relays have been disconnected include relays arranged between two power sources. Test nodes are positioned between the relays on each line, and feed into a detection circuit. Voltage drop resistors, voltage drop diodes, an optocoupler, and additional resistors and capacitors are used to provide voltage isolation for the detection circuit. Relays are methodically opened and closed to check the individual functioning of each relay, and a digital signal generated from the detection circuit. The design of the system with detection circuit isolation provides a safer and lower cost system for verifying that relays are operating correctly, with less costly components than traditional systems.

Abstract: This present disclosure relates to series compounds and methods of use for the treatment of a disease caused by abnormal regulation of the ubiquitin-proteasome system (UPS), and wherein said compound is an effective stimulator of the 20S core particle (CP) of the UPS. Composition matters and methods of uses are within the scope of this disclosure.

Abstract: Aspects of the present disclosure generally relate to immunotherapy, cancer vaccines and the treatment of cancer diseases. By way of example, the present disclosure relates to novel combined with an immunologically effective amount of adjuvant, for treating cancer in a subject methods of generating such formulations, and methods of use thereof.

Abstract: A compensation device for compensating PVT variations of an analog and/or digital circuit. The compensation device includes a transistor having a first terminal, a second terminal, a third terminal, and a fourth terminal allowing to modify a threshold voltage of the transistor. The transistor is configured to be in saturation region. The voltage at the third terminal has a predetermined value and the difference between the voltage at the second terminal and the voltage at the third terminal has a predetermined value. A current generation module is configured to generate a current of a predetermined value. A compensation module is configured to force this current to flow between the first terminal and the third terminal by adjusting the voltage of the fourth terminal.

Abstract: A multi-level inverter includes a coupling to a DC power source and a coupling to an AC power source, a plurality of capacitors arranged to create a set of nodes, and a plurality of switches located between the capacitors and the AC power source. Switches are configured to create an AC bypass in which the capacitors coupled to the DC power source may be isolated from the AC power source. The AC bypass is utilized as one of the switching states in a switching sequence that provides enhanced performance including but not limited to reduced electromagnetic interference and ripple.

Abstract: Systems and methods for automatically verifying that power relays have been disconnected are disclosed. Relays are arranged between two power sources. Test nodes are positioned between the relays on each line, and feed into a detection circuit. Voltage drop resistors, voltage drop diodes, an optocoupler, and additional resistors and capacitors are used to provide voltage isolation for the detection circuit. Relays are methodically opened and closed to check the individual functioning of each relay, which is verified by means of a digital signal generated from the detection circuit. The design of the system with detection circuit isolation provides a safer and lower cost system for verifying that relays are operating correctly, with less costly components than traditional systems.

Abstract: A multi-level inverter includes a coupling to a DC power source and a coupling to an AC power source, a plurality of capacitors arranged to create a set of nodes, and a plurality of switches located between the capacitors and the AC power source. Switches are configured to create an AC bypass in which the capacitors coupled to the DC power source may be isolated from the AC power source. The AC bypass is utilized as one of the switching states in a switching sequence that provides enhanced performance including but not limited to reduced electromagnetic interference and ripple.

Abstract: A compensation device for compensating PVT variations of an analog and/or digital circuit. The compensation device includes a transistor having a first terminal, a second terminal, a third terminal, and a fourth terminal allowing to modify a threshold voltage of the transistor. The transistor is configured to be in saturation region. The voltage at the third terminal has a predetermined value and the difference between the voltage at the second terminal and the voltage at the third terminal has a predetermined value. A current generation module is configured to generate a current of a predetermined value. A compensation module is configured to force this current to flow between the first terminal and the third terminal by adjusting the voltage of the fourth terminal.

Abstract: The present invention relates to an ex vivo, fast and efficient process to obtain activated antigen-presenting cells that are useful for therapies against cancer and immune system-related diseases. At the same time, it is related to a cellular composition that contributes to stimulate the activated antigen-presenting cells to induce a specific immune response against tumors in patients with cancer or other pathologies involving immune responses.

Abstract: The present invention relates generally to a colloidal silver generator and more specifically to an ultrasonic nano silver generator that generates nano size silver particles, with a range of 1 nm to 100 nm in size, using ultrasound under electrolysis. By improving the architectural efficiency, limiting particle aggregation and managing particle saturation, the present invention improves upon previous attempts of generating nano silver particles.

Abstract: We disclose here a method for using Poly-ICLC to prevent and/or treat certain human and veterinary infectious, neoplastic and autoimmune disorders, as well as for regulating a broad variety of genes in humans, consisting of use of poly-ICLC repeatedly and at low doses, alone or in combination with other drugs or vaccines. As such it represents an example of broad spectrum host-targeted therapeutics, in contrast to conventional antibiotics, antiviral or antineoplastic agents that target specific organisms or tumors.

Abstract: The present invention relates to an ex vivo, fast and efficient process to obtain activated antigen-presenting cells that are useful for therapies against cancer and immune system-related diseases. At the same time, it is related to a cellular composition that contributes to stimulate the activated antigen-presenting cells to induce a specific immune response against tumors in patients with cancer or other pathologies involving immune responses.

Abstract: An improved autovaccination method designed to prevent or treat various neoplastic diseases by inducing a systemic immune response against a tumor and its remote metastases, consisting of the induction of an immunogenic cell death in one or more targeted tumor sites with local radiation therapy, cryotherapy, heat, chemotherapy or various other treatments, followed by intratumoral/peritumoral injection of dsRNAs (poly-ICLC in particular) in the same tumor site.

Abstract: We disclose here a method for using Poly-ICLC to prevent and/or treat certain human and veterinary infectious, neoplastic and autoimmune disorders, as well as for regulating a broad variety of genes in humans, consisting of use of poly-ICLC repeatedly and at low doses, alone or in combination with other drugs or vaccines. As such it represents an example of broad spectrum host-targeted therapeutics, in contrast to conventional antibiotics, antiviral or antineoplastic agents that target specific organisms or tumors.

Abstract: Method for producing large lots of final sterile Poly-ICLC suitable for clinical use with reduced toxicity at effective dose levels, and method for using Poly-ICLC to regulate genes, and method for using Poly-ICLC to treat certain human and veterinary infectious, neoplastic and autoimmune disorders.

Abstract: An improved understanding and method for the clinical adjuvant and immunomodulatory use of dsRNAs and ply-ICLC in particular, alone or in conjunction with other drugs and various vaccines designed to prevent or treat various microbial, viral, neoplastic, autoimmune diseases, and or degenerative diseases.