Abstract: A method for assessing the integrity of a bioprocessing system includes the steps of determining a mass of a first container, transferring a volume of fluid from the first container to a second container, determining the mass of the second container, comparing the mass of the first container with the mass of the second container, and, if the difference between the mass of the first container and the mass of the second container exceeds a threshold, generating a notification indicating that a leak is present.

Abstract: A method of bioprocessing includes the steps of providing a bioreactor vessel having a gas-permeable, liquid impermeable membrane, initiating a flow of gas, and passing the flow of gas across a bottom surface of the membrane to induce a turbulent interaction between the flow of gas and the membrane.

Abstract: A rocking mechanism for a bioreactor vessel includes a base, a motor mounted to the base and having an eccentric roller driven by the motor, and a rocking plate in contact with the eccentric roller, the rocking plate being configured to receive a bioreactor vessel thereon. The motor is controllable to drive the eccentric roller to transmit a force against an underside of the rocking plate to tilt the rocking plate and bioreactor vessel.

Abstract: A bioprocessing apparatus includes a housing, a process drawer receivable within the housing and moveable between a closed position and an open position, the process drawer being configured to receive at least one culture vessel therein, and a cabinet positioned in stacked vertical relation to the housing, the cabinet including at least one vertical storage drawer slidably received within the cabinet.

Abstract: A method for assessing the integrity of a bioprocessing system includes the steps of utilizing a pump of a bioprocessing system, pressurizing a plurality of flow lines, and measuring a decay of a pressure within the plurality of flow lines for a predetermined a duration.

Abstract: A bioreactor vessel includes a base having a plurality of through openings, a lid connected to the base via a plurality of heat stakes, and a gas-permeable, liquid impermeable membrane sandwiched between the base and the lid and held in position by the plurality heat stakes.

Abstract: Sample taking device for extracting a fluid sample from a vessel comprising: a cover portion for closing the vessel such that, in use a headspace is defined between the cover portion and fluid held in the vessel, a sampling chamber comprising a sampling inlet and a sampling outlet, a cannula adapted to provide, in use, fluid communication between the fluid held in the vessel and the sampling chamber through the sampling inlet, and ports to operate the device in at least two operating conditions: a sample preparing condition in which a pressure in the headspace is greater than that of the sampling chamber such that fluid flows through the cannula towards the sampling chamber and can be retained therein, and a sample dispensing condition in which fluid retained in the sampling chamber can be delivered through the sampling outlet and fluid remaining inside the cannula can return to the vessel.

Abstract: Sample taking device for extracting a fluid sample from a vessel comprising: a cover portion for closing the vessel such that, in use a headspace is defined between the cover portion and fluid held in the vessel, a sampling chamber comprising a sampling inlet and a sampling outlet, a cannula adapted to provide, in use, fluid communication between the fluid held in the vessel and the sampling chamber through the sampling inlet, and ports to operate the device in at least two operating conditions: a sample preparing condition in which a pressure in the headspace is greater than that of the sampling chamber such that fluid flows through the cannula towards the sampling chamber and can be retained therein, and a sample dispensing condition in which fluid retained in the sampling chamber can be delivered through the sampling outlet and fluid remaining inside the cannula can return to the vessel.

Abstract: The device comprises a loading portion (2a) for loading biological material thereon, and a channel (C) arranged for conducting a warming solution there through and for applying it over said biological material while loaded on said loading portion (2a), for an in-situ warming. The use comprises simultaneously warming and transferring a cryopreserved biological material loaded on a device loading portion, by conducting and applying a warming solution on the biological material loaded on the device loading portion.