Abstract: Provided herein are compounds of the Formula (I): (I) and tautomers, stereoisomers and pharmaceutically acceptable salts and solvates thereof, wherein Rx, Ry, W, X, Y, Z, Ring A and (AA) have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

Abstract: A head-mounted device is provided that includes displays configured to display an image and to simultaneously display a magnifying window that presents a magnified portion of the image. The magnifying window lies in a magnification plane that is fixed relative to a user's head. One or more processors in the head-mounted device can be used to perform a first ray cast operation to identify an input point where a detected user input intersects the magnifying window, to obtain a remapped point from the input point, to compute a directional vector based on the remapped point and a reference point associated with the user's head, to obtain a shifted point by shifting the remapped point from the magnification plane to another plane parallel to the magnification plane, and to perform a second ray cast operation using the shifted point and the directional vector.

Abstract: Provided are orthodontic devices to orthopedically expand the upper jaw including a pre-formed arch wire adapted to conform to the interior contours of a patient's mouth. The arch includes a rear portion positioned at a level about a patient's rear molars and includes a first end and a second end adapted to slidably engage associated buccal tubes. The arch also includes a front portion positioned at a level above a patient's gingiva and into the patient's vestibule, and a rise portion between the rear portion and front portion that changes the effective level of the arch wire from the rear portion to the front portion. The device also includes a means for attaching the wire to the molar teeth.

Abstract: Provided are orthodontic devices to orthopedically expand the upper jaw including a pre-formed arch wire adapted to conform to the interior contours of a patient's mouth. The arch includes a rear portion positioned at a level about a patient's rear molars and includes a first end and a second end adapted to slidably engage associated buccal tubes. The arch also includes a front portion positioned at a level above a patient's gingiva and into the patient's vestibule, and a rise portion between the rear portion and front portion that changes the effective level of the arch wire from the rear portion to the front portion. The device also includes a means for attaching the wire to the molar teeth.

Abstract: A die for die-casting a V-block for an internal combustion engine may be operated by a wide range of die-casting machines, including those with inadequate capacity to operate the normally heavy dies for large cast parts. Such a die includes, in addition to a stationary die element for the stationary platen of a die-casting machine, only a single movable die element carried by the tie bars and slides of a die-casting machine and carrying the cylinder-forming die core pieces, means for locking the die core pieces in their extended cylinder-forming positions, and the plurality of cavity-forming slides.

Abstract: A die for die-casting a V-block for an internal combustion engine may be operated by a wide range of die-casting machines, including those with inadequate capacity to operate the normally heavy dies for large cast parts. Such a die includes, in addition to a stationary die element for the stationary platen of a die-casting machine, only a single movable die element carried by the tie bars and slides of a die-casting machine and carrying the cylinder-forming die core pieces, means for locking the die core pieces in their extended cylinder-forming positions, and the plurality of cavity-forming slides.