Abstract: In at least one embodiment a computer implemented method is disclosed. A computer process is extracted from a first environment including a unique process parameter and a first non-unique process parameter. The computer process is configured to execute a primary domain operation. The computer process is configured to execute the primary domain operation in a second environment comprising the unique process parameter and a second non-unique process parameter. The unique process parameter is input to the computer process and the primary domain operation is executed with the computer process in the second environment in response to inputting the unique process parameter to the computer process.

Abstract: A computer implemented process is defined to operate on three types of objects: Task Objects, Resume Objects, and State Objects. To define a Task Objects are implemented to perform the actions required to complete a particular aspect of the process. A State Object maintains information about the currently executing process, such as the values of variables and the current location in the executing process. A Resume Object directs process execution by specifying which Task Objects or Resume Objects to execute next. A key aspect of the system is the ability to suspend execution at any time and seamlessly resume execution at either the exact point execution was stopped or at any execution point prior to suspension. This accomplished by periodically storing Snapshots of the execution to persistent storage, which can later be used to restore the state of the system to that of the Snapshot.

Abstract: Methods to generate analogs of coenzyme A in vitro and in vivo are disclosed. The methods comprise reacting pantetheine or a derivative thereof with a reporter to form labeled pantetheine or a derivative thereof, phosphorylating the labeled pantetheine or derivative thereof to form phosphopantetheine or a derivative thereof, adenylating the labeled phosphopantetheine or derivative thereof to form a labeled dephosphoCoenzyme A or derivative thereof, and phosphorylating the 3?-hydrozyl of the labeled dephosphoCoenzume A or derivative thereof to form a labeled coenzyme A analog or derivative thereof.

Abstract: The invention is based on the discovery that a viral VEGF-like protein from the orf virus strain NZ2 and from the orf virus strain NZ10 is capable of binding to the extracellular domain of the VEGF receptor-2 to form bioactive complexes which mediate useful cellular responses and/or antagonize undesired biological activities. Disclosed are methods which stimulate or inhibit these biological activities, methods for therapeutic applications and antagonists of ORFV2-VEGF and/or NZ10.

Abstract: The invention is based on the discovery that a viral VEGF-like protein from the orf virus strain NZ2 and from the orf virus strain NZ10 is capable of binding to the extracellular domain of the VEGF receptor-2 to form bioactive complexes which mediate useful cellular responses and/or antagonize undesired biological activities. Disclosed are methods which stimulate or inhibit these biological activities, methods for therapeutic applications and antagonists of ORFV2-VEGF and/or NZ10.