Abstract: Disclosed is a module for efficiently exciting and detecting fluorescence. In a disclosed preferred embodiment, excitation lamp modules with multiple solid-state light sources shone at different oblique angles, such that multiple-beams converge in a single plane, are combined with appropriate emission filters that block the excitation light wavelengths while passing the emission wavelengths. A multitude of such modules can be combined on a slider with precise registration via a mating structure, and can be accurately positioned in front of an observation point, such as a microscope's objective lens, external to the microscope, via a novel magnetic detent system, allowing for the rapid switching between the analysis of different fluorophores.

Abstract: An automatic chemical solution formulating device combines and mixes stored solids and liquids into user specified formulations and dispenses those formulations into containers. Chemical solids are stored in cartridges of material separated into predetermined dosages (for example in reeled blister packs), avoiding the need for weighing during formulation. Elements include user interface, computer-controlled automated loading and unloading port for reagent-containing cartridges, cartridge conveyor system, reader for identifying cartridges, blister-pack strip drive system, punching mechanism to release reagents, portioning chamber to mix solvent with solids or liquids with optional portioning, accommodating formulation delivery port, position sensors, liquid flow measuring devices, liquid and gas pumps and valves, and label printer. The combination of these elements allows high-speed formulation and dispensing of user-specified formulations.

Abstract: An automatic chemical solution formulating device combines and mixes stored solids and liquids into user specified formulations and dispenses those formulations into containers. Chemical solids are stored in cartridges of material separated into predetermined dosages (for example in reeled blister packs), avoiding the need for weighing during formulation. Elements include user interface, computer-controlled automated loading and unloading port for reagent-containing cartridges, cartridge conveyor system, reader for identifying cartridges, blister-pack strip drive system, punching mechanism to release reagents, portioning chamber to mix solvent with solids or liquids with optional portioning, accommodating formulation delivery port, position sensors, liquid flow measuring devices, liquid and gas pumps and valves, and label printer. The combination of these elements allows high-speed formulation and dispensing of user-specified formulations.

Abstract: Disclosed are a method and associated apparatus for efficiently exciting and detecting fluorescence. In a disclosed preferred embodiment, excitation lamp modules with multiple solid-state light sources shone at different oblique angles, such that multiple-beams converge in a single plane, are combined with appropriate emission filters that block the excitation light wavelengths while passing the emission wavelengths. A multitude of such modules are combined on a slider that can be accurately positioned in front of an observation point, such as a microscope's objective lens, external to the microscope, via a novel magnetic detent system, allowing for the rapid switching between the analysis of different fluorophores.

Abstract: Disclosed are a method and associated apparatus for efficiently exciting and detecting fluorescence. In a disclosed preferred embodiment, excitation lamp modules with multiple solid-state light sources shone at different oblique angles, such that multiple-beams converge in a single plane, are combined with appropriate emission filters that block the excitation light wavelengths while passing the emission wavelengths. A multitude of such modules are combined on a slider that can be accurately positioned in front of an observation point, such as a microscope's objective lens, external to the microscope, via a novel magnetic detent system, allowing for the rapid switching between the analysis of different fluorophores.

Abstract: Disclosed are an apparatus and a method for remotely monitoring and controlling various processes in an incubation/reaction system. Remote control is accomplished via computer network protocol. In a disclosed preferred embodiment, remote observation and control is accomplished via a “web server” program running on a computer attached to or embedded within the body of the system, interfacing with temperature monitoring and control means, digital video camera photomicroscope means, atmospheric monitoring and control means, and other devices for monitoring or affecting contents of the system. The web server sends data to and receives data from any computer running a “web browser” program. Bi-directional communication is possible over secured and unsecured channels and can penetrate firewall software to allow real-time communication between a user and a chamber when each is behind a different firewall.

Abstract: A new quickly replaceable electrode assembly for electroporation that also provides the functions of a pipette, capable of sucking up samples; applying extremely high electric field strength to samples at lower, safer voltages due to close spacing of the electrode plates; and expelling samples quickly and completely; along with a quick-connect receptacle for the electrode assembly. New methods are detailed for construction of electrode assemblies, providing electric current, monitoring characteristics of electric pulses delivered to samples, and space saving hand held units using low voltage D.C., A.C. line, and piezoelectric power supplies, with peak current delivered indicators are disclosed.

Abstract: A photoelectric electrophoresis controller triggered by molecular samples and/or molecular marker dyes sensed by photodetector means when reaching determined position in a matrix, characterized by an observing photocell spaced from a reference photocell for comparison, and sampling by electronic means rejecting spurious signals, with control to respond with a detection signal to user-specified light transmission increased or decreased by the sample and/or molecular marker.