Patents by Inventor Andrew A. Pham

Andrew A. Pham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detector and screening device for ion channels
    Patent number: 6608671
    Abstract: The invention provides for a detector assembly, fiber assembly and screening system for optical measurements.
    Type: Grant
    Filed: July 17, 1998
    Date of Patent: August 19, 2003
    Assignee: Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Roger Y. Tsien, Peter J. Coassin, Andrew A. Pham, Alec Tate Harootunian, Minh Vuong
  • Multi-well platforms, caddies, lids and combinations thereof
    Publication number: 20030039591
    Abstract: The present invention relates to multi-well platforms, lids, caddies and any combination thereof. The multi-well platforms comprise a plurality of wells that can be of any shape and can be arranged in any ornamental pattern. The lid comprises an area corresponding to the well field. The caddy has a footprint approximately that of a standard 96-well microtiter plate. When the multi-well platform is engaged with the caddy, the wells of the well-field of the multi-well platform are preferably not obscured by the caddy when viewed from the bottom of the combination.
    Type: Application
    Filed: July 30, 2002
    Publication date: February 27, 2003
    Applicant: Aurora Biosciences, Inc. (now Vertex Pharmaceuticals, LLC)
    Inventors: Andrew A. Pham, Peter J. Coassin, Alec Tate Harootunian, Peter N. Pham, Harry Stylli, Roger Y. Tsien
  • Low fluorescence assay platforms and related methods for drug discovery
    Patent number: 6517781
    Abstract: One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform for fluorescence measurements. A further aspect of the present invention is a method for detecting the presence of an analyte in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a method from identifying a modulator of a biological process or target in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a composition identified by this method. A further aspect of the present invention is a method to identify a therapeutic.
    Type: Grant
    Filed: January 3, 2000
    Date of Patent: February 11, 2003
    Assignee: Aurora Biosciences Corporation
    Inventors: Peter J. Coassin, Alec Tate Harootunian, Andrew A. Pham, Harry Stylli, Roger Y. Tsien
  • Low fluorescence assay platforms and related methods for drug discovery
    Publication number: 20020155617
    Abstract: One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform for fluorescence measurements. A further aspect of the present invention is a method for detecting the presence of an analyte in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a method from identifying a modulator of a biological process or target in a sample contained in a multi-well platform by detecting light emitted from the sample Another aspect of the present invention is a composition identified by this method. A further aspect of the present invention is a method to identify a therapeutic.
    Type: Application
    Filed: April 9, 2002
    Publication date: October 24, 2002
    Applicant: Aurora Biosciences Corporation
    Inventors: Andrew A. Pham, Peter J. Coassin, Alec Tate Harootunian, Harry Stylli, Roger Y. Tsien
  • Multi-well platforms, caddies, lids and combinations thereof
    Patent number: 6426050
    Abstract: The present invention relates to multi-well platforms, lids, caddies and any combination thereof The multi-well platforms comprise a plurality of wells that can be of any shape and can be arranged in any ornamental pattern. The lid comprises an area corresponding to the well field. The caddy has a footprint approximately that of a standard 96-well microtiter plate. When the multi-well platform is engaged with the caddy, the wells of the well-field of the multi-well platform are preferably not obscured by the caddy when viewed from the bottom of the combination.
    Type: Grant
    Filed: July 7, 1998
    Date of Patent: July 30, 2002
    Assignee: Aurora Biosciences Corporation
    Inventors: Andrew A. Pham, Peter J. Coassin, Alec Tate Harootunian, Peter N. Pham, Chari Stylli, Roger Y. Tsien
  • Detector and screening device for ion channels
    Patent number: 6349160
    Abstract: The present invention is relates to an optical fiber assembly which may be used in an optical detection system. The optical fiber assembly may comprise a trifurcated cable and a ball lens in optical communication with the trifurcated cable. The trifurcated cable may comprise an excitation bundle, a first emission bundle for receiving light and a second emission bundle for receiving light.
    Type: Grant
    Filed: July 24, 1998
    Date of Patent: February 19, 2002
    Assignee: Aurora Biosciences Corporation
    Inventors: Roger Y. Tsien, Peter J. Coassin, Andrew A. Pham, Alec Tate Harootunian, Minh Vuong
  • DETECTOR AND SCREENING DEVICE FOR ION CHANNELS
    Publication number: 20020008867
    Abstract: The invention provides for a detector assembly. fiber assembly and screening system for optical measurements.
    Type: Application
    Filed: July 24, 1998
    Publication date: January 24, 2002
    Inventors: ROGER Y. TSIEN, PETER J. COASSIN, ANDREW A. PHAM, ALEC TATE HAROOTUNIAN, MINH VUONG
  • DETECTOR AND SCREENING DEVICE FOR ION CHANNELS
    Publication number: 20020001075
    Abstract: The invention provides for a detector assembly, fiber assembly and screening system for optical measurements.
    Type: Application
    Filed: July 17, 1998
    Publication date: January 3, 2002
    Inventors: ROGER Y. TSIEN, PETER J. COASSIN, ANDREW A. PHAM, ALEC TATE HAROOTUNIAN, MINH VUONG
  • Low background multi-well plates for fluorescence measurements of biological and biochemical samples
    Patent number: 6232114
    Abstract: The invention provides for multi-well plates and platforms that comprise a layer of cycloolefin having low fluorescence and high transmittance. These multi-well plates and platforms are particularly well suited for fluorescent measurements.
    Type: Grant
    Filed: June 3, 1997
    Date of Patent: May 15, 2001
    Assignee: Aurora Biosciences Corporation
    Inventors: Peter J. Coassin, Alec Tate Harootunian, Andrew A. Pham, Roger Y. Tsien
  • Low background multi-well plates with greater than 864 wells for spectroscopic measurements
    Patent number: 6229603
    Abstract: The invention provides for multi-well plates with greater than 864 wells that comprise a layer of cycloolefin having low fluorescence and high transmittance. These multi-well plates are particularly well suited for fluorescent measurements.
    Type: Grant
    Filed: June 2, 1997
    Date of Patent: May 8, 2001
    Assignee: Aurora Biosciences Corporation
    Inventors: Peter J. Coassin, Alec Tate Harootunian, Roger Y. Tsien, Andrew A. Pham
  • Low fluorescence assay platforms and related methods for drug discovery
    Patent number: 6171780
    Abstract: One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform for fluorescence measurements. A further aspect of the present invention is a method for detecting the presence of an analyte in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a method from identifying a modulator of a biological process or target in a sample contained in a multi-well platform by detecting light emitted from the sample. Another aspect of the present invention is a composition identified by this method. A further aspect of the present invention is a method to identify a therapeutic.
    Type: Grant
    Filed: February 24, 1998
    Date of Patent: January 9, 2001
    Assignee: Aurora Biosciences Corporation
    Inventors: Andrew A. Pham, Peter J. Coassin, Alec Tate Harootunian, Harry Stylli, Roger Y. Tsien
  • Low background multi-well plates and platforms for spectroscopic measurements
    Patent number: 6063338
    Abstract: The invention provides for multi-well plates and platforms that comprise a layer of cycloolefin having low fluorescence and high transmittance. These multi-well plates and platforms are particularly well suited for fluorescent measurements.
    Type: Grant
    Filed: June 2, 1997
    Date of Patent: May 16, 2000
    Assignee: Aurora Biosciences Corporation
    Inventors: Andrew A. Pham, Peter J. Coassin, Alec Tate Harootunian, John D. Mendlein, Roger Y. Tsien
  • Low background multi-well plates with greater than 864 wells for fluorescence measurements of biological and biochemical samples
    Patent number: 5910287
    Abstract: The invention provides for multi-well plates with greater than 864 wells that comprise a layer of cycloolefin having low fluorescence and high transmittance. These multi-well plates are particularly well suited for fluorescence measurements.
    Type: Grant
    Filed: June 3, 1997
    Date of Patent: June 8, 1999
    Assignee: Aurora Biosciences Corporation
    Inventors: Peter J. Cassin, Alec Tate Harootunian, Andrew A. Pham, Roger Y. Tsien
  • High-pressure micro-volume syringe pump
    Patent number: 5656034
    Abstract: A syringe pump particularly adapted for delivery of small volumes at a high pressure in an accurate and reproducible manner. The syringe pump includes a frame, a motor attached to the frame, and a lead screw drivably connected to the motor. A cover seal is mounted to the front end of the lead screw, the cover seal having grooves formed therein to facilitate mounting and demounting of the cover seal. The pump further includes a cylindrical barrel within which the cover seal reciprocates, the barrel being made of a ceramic material, wherein the barrel is fixedly attached to the frame at the front end and floatably mounted to the frame at the back end. A barrel head is mounted to the front end of the barrel for closing off that end of the barrel, the barrel head including an outlet port for allowing fluid to enter and exit the barrel. In addition, the present invention includes a multi-syringe gradient syringe pump, a liquid chromatography system, a cover seal, and a mixer for mixing multiple flow streams.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: August 12, 1997
    Inventors: Michael L. Kochersperger, Reid B. Kowallis, Andrew A. Pham
  • Multi-well platform
    Patent number: D454202
    Type: Grant
    Filed: January 12, 1998
    Date of Patent: March 5, 2002
    Assignee: Aurora Biosciences Corporation
    Inventors: Andrew A. Pham, Peter J. Coassin, Alec Tate Harootunian, Peter N. Pham
  • Platform for a multi-well field
    Patent number: D428157
    Type: Grant
    Filed: January 12, 1998
    Date of Patent: July 11, 2000
    Assignee: Aurora Biosciences Corporation
    Inventors: Peter J. Coassin, Andrew A. Pham, Peter N. Pham