Abstract: The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases.

Abstract: The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, A, p, L, U, V and W have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: The present invention encompasses compounds of formula (V) wherein R1a, R1b, R2a, R2b, Z, R4, R5, R14, A, p, X, U, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: A chemical synthesis plant comprising: one or more reactors configured for producing, from one or more reactants, a process stream comprising at least one chemical product; a feed preparation system configured to prepare one or more feed streams comprising one or more of the one or more reactants for introduction into the one or more reactors; and/or a product purification system configured to separate the at least one chemical product from reaction byproducts, unreacted reactants, or a combination thereof within the process stream, wherein the chemical synthesis plant is configured such that a majority of the net energy needed for heating, cooling, compressing, or a combination thereof utilized via the one or more reactors, the feed preparation system, the product purification system, or a combination thereof is provided from a non-carbon based energy source, from a renewable energy source, and/or from electricity.

Abstract: The present invention encompasses compounds of formula (I) wherein R1a, R1b, R2a, R2b, Z, R3 to R5, ring A, ring B, p, q, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: A method for delaminating an electrode material of an electrode sheet from a current collector of the electrode sheet comprises positioning the electrode sheet in a sonicating bath, and at least partially within a target area of a sonotrode, wherein, in the target area, the distance between a front face of the sonotrode and the electrode sheet is less than or equal to 2 cm; and ultrasonically treating the electrode sheet, using the sonotrode, with a power density at the sonotrode front face greater than or equal to 50 W/cm2. An electrode material delaminating apparatus for performing the method is also disclosed.

Abstract: A circuit for transmission and reception of multi-channel communications is disclosed. The transmitter path includes a digital modulation circuit receiving multiple channel binary data, and for each channel generating a digital representation of the data. A digital-to-analogue (D/A) conversion circuit (140-146) is provided for each data channel. Each D/A conversion circuit receives and converts respective channel digital representations to produce a resultant band limited analogue signal (148-154). The band limitation arises due to a characteristic of said channel digital representations. A bandpass filter (156-162) receives and filters each analogue channel signal. The band width to the start of the stop band of each bandpass filter is wider than a respective band limited analogue channel signal and wider than the Nyquist bandwidth arising from the sampling rate of said D/A conversion circuit. In this way, signal power in unwanted Nyquist zones is effectively removed.

Abstract: A circuit for transmission and reception of multi-channel communications is disclosed. The transmitter path includes a digital modulation circuit receiving multiple channel binary data, and for each channel generating a digital representation of the data. A digital-to-analogue (D/A) conversion circuit (140-146) is provided for each data channel. Each D/A conversion circuit receives and converts respective channel digital representations to produce a resultant band limited analogue signal (148-154). The band limitation arises due to a characteristic of said channel digital representations. A bandpass filter (156-162) receives and filters each analogue channel signal. The band width to the start of the stop band of each bandpass filter is wider than a respective band limited analogue channel signal and wider than the Nyquist bandwidth arising from the sampling rate of said D/A conversion circuit. In this way, signal power in unwanted Nyquist zones is effectively removed.

Abstract: A floating moored oilfield production structure for deepwater application. An apparatus and a method for the construction and installation of floating oilfield production structures, wherein the deck structure is supported by multiple pairs of inclined buoyant legs which in turn support a subsurface damping plate structure for reducing the motions of the platform. The structure initially is initially constructed in a first configuration in relatively shallow water and then towed to a deepwater location where it is reconfigured to its operational configuration. The major structural components are joined by selectably operable pin connections.

Abstract: An extendable draft platform, having a deck and buoyancy columns installed in leg wells in the deck for vertical movement from a raised position to a submerged position, includes a connection arrangement for securing the columns to the deck when the columns are in the submerged position. In the connection arrangement, a plurality of first guide elements near the top of each column is engageable by a plurality of complementary second guide elements secured to the deck around each leg well when the column is lowered to its submerged position. A locking mechanism is operable between the columns and the deck when the first guide elements are engaged with the second guide elements. The first and second guide elements may be configured so that the connection between the deck and the columns may be enhanced by over-ballasting the columns and/or by welding the columns to the deck.

Abstract: Ionic compounds having a freezing point of no more than 50° C., formed by the reaction of at least one amine salt of the formula R1R2R3R4N+X− (I) with at least one hydrated salt, which is a chloride, nitrate, sulphate or acetate of Li, Mg, Ca, Cr, Mn, Fe, Co, Ni, Cu, Zn, Cd, Pb, Bi, La or Ce; wherein R1, R2 and R3 are each independently a C1 to C5 alkyl or a C6 to C10 cycloalkyl group, or wherein R2 and R3 taken together represent a C4 to C10 alkylene group, thereby forming with the N atom of formula (I) a 5 to 11 membered heterocyclic ring, and wherein R4 is hydrogen, or phenyl, or C1 to C12 alkyl or cycloalkyl group, optionally substituted with at least one group selected from OH, Cl, Br, F, I, phenyl, NH2, CN, NO2, COOR5, CHO, COR5 and OR5, wherein R5 is a C1 to C10 alkyl or cycloalkyl group, and X− is an anion capable of being complexed by the said hydrated salt.

Abstract: The present invention concerns class II cytochrome P450s, electrochemical systems for assaying cytochrome P450 catalytic activity, apparatus and methods for same.

Abstract: An elongated deck section having two rows of legs with several legs per row is fabricated with the legs hingedly mounted on footings adapted to receive fluid bearings and is transported from the fabricating yard to a dock head over a smooth concrete slab of minimal slope and thence longitudinally via fluid bearing adapted gang planks and tracks onto and along a barge disposed with its stern adjacent the dock head and grounded thereat, the platform being transported by placing fluid bearings under the footings which allow the section to be moved sideways, lengthways, or rotated or turned, as desired, the deck's horizontal truss stresses and the fluid bearing loads being controlled by actuating fluid elevators between each leg and the fluid bearing thereunder, the barge being initially ballasted so that change of ballast during loading is unnecessary to maintain minimal slope of the barge, the section then being anchored to the barge and the barge reballasted to float its stern and trim the barge preparatory to