Patents by Inventor Andrew Alt

Andrew Alt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Continuous process for manufacturing alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridine-carboxylate
    Patent number: 11976082
    Abstract: This invention relates to a novel continuous process for making alkyl 7-amino-5-methyl-[1,2,5]-oxadiazolo¬[3,4-b]pyridine-carboxylate, wherein R is C1-3-alkyl. The process of the invention present invention overcomes disadvantages of processes of the prior art by avoiding the highly energetic intermediates, using readily available and inexpensive starting materials and reagents, and avoiding the isolation of intermediates. The process according to the invention is suitable for use on industrial scale.
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: May 7, 2024
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Bernd Werner, Tobias Alt, Andrew T. Brusoe, Frederic Gerard Buono, Michael Klumb, Bjoern Stahl, Thomas G. Tampone
  • METHODS AND COMPOSITIONS FOR TREATING CHRONIC RHINOSINUSITIS
    Publication number: 20200237804
    Abstract: Described herein is the use of a methylated/sulfated hyaluronan, sulfated hyaluronan, or the pharmaceutically acceptable salt or ester thereof for the treatment of chronic rhinosinusitis.
    Type: Application
    Filed: October 18, 2018
    Publication date: July 30, 2020
    Inventors: Glenn D. PRESTWICH, Abigail PULSIPHER, Thomas P. KENNEDY, Jeremiah Andrew ALT
  • POSITIVE ALLOSTERIC MODULATORS OF THE DELTA-OPIOID RECEPTOR
    Publication number: 20170370929
    Abstract: Described are the discovery, synthesis and pharmacological characterization of ?-opioid receptor-selective positive allosteric modulators (? PAMs). These ? PAMs may increase the affinity and/or efficacy of the orthosteric agonists leu-enkephalin and SNC80, as measured by ?-arrestin recruitment and adenylyl cyclase inhibition. The compounds may be useful pharmacological tools to probe the molecular pharmacology of the ? receptor and to explore the therapeutic potential of ? PAMs in diseases such as chronic pain and depression.
    Type: Application
    Filed: December 17, 2015
    Publication date: December 28, 2017
    Inventors: Neil T. Burford, Ying Han, Martyn N. Banks, Litao Zhang, Samuel Gerritz, Andrew Alt
  • Positive allosteric modulators and silent allosteric modulators of the Mu opioid receptor
    Patent number: 9784740
    Abstract: Disclosed are positive allosteric modulators (PAMs) and silent allosteric modulators (SAMs) for mu (?)-opioid receptors that may be useful for the treatment of pain, either alone or in combination with orthosteric opioid receptor agonists. Methods for treating pain and modulating mu (?)-opioid receptors are also disclosed.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: October 10, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Neil Burford, Andrew Alt
  • POSITIVE ALLOSTERIC MODULATORS AND SILENT ALLOSTERIC MODULATORS OF THE Mu OPIOID RECEPTOR
    Publication number: 20150338404
    Abstract: Disclosed are positive allosteric modulators (PAMs) and silent allosteric modulators (SAMs) for mu (?)-opioid receptors that may be useful for the treatment of pain, either alone or in combination with orthosteric opioid receptor agonists. Methods for treating pain and modulating mu (?)-opioid receptors are also disclosed.
    Type: Application
    Filed: December 20, 2013
    Publication date: November 26, 2015
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Neil Burford, Andrew Alt