Abstract: Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4-position via N(H), C(O) or O moieties.

Abstract: A user device is operable to determine a query request based on first user input to a graphical user interface displayed by the user device. Query cost data is determined based on the query request. A prompt is displayed via the graphical user interface that indicates the query cost data. Query approval data is determined based on second user input to the graphical user interface in response to the prompt. The query request is transmitted to an analytics system for execution against a database system when the query approval data indicates approval to transmit the query request.

Abstract: A surgical stapler includes a first stapler half including an anvil surface having a plurality of staple forming pockets, and a second stapler half configured to releasably couple with the first stapler half. The second stapler half is operable to deploy staples toward the anvil surface. The stapler also includes a projection positioned on one of the stapler halves and extending laterally relative to a longitudinal axis of the stapler. The stapler halves are configured to pivot relative to each other about the projection. The stapler further includes a locking member positioned on the other of the stapler halves. The locking member is configured to translate along the longitudinal axis of the stapler between a locked state in which the locking member selectively captures the projection and an unlocked state in which the locking member selectively releases the projection. The locking member is biased proximally toward the locked state.

Abstract: A node of a database system is operable to receive a plurality of data blocks from a set of source nodes via a set of relay nodes. At least one feedback data block to be sent to at least one of the set of source nodes is generated. Feedback relay node selection data selecting at least one of a plurality of nodes in the database system for facilitating routing of the at least one feedback data block from the node to the at least one of the set of source nodes via a prioritized feedback communication mechanism is generated. The at least one feedback data block is sent to the at least one of the plurality of nodes selected in the feedback relay node selection data. The at least one feedback data block is routed from the node to the at least one of the set of source nodes via the prioritized feedback communication mechanism.

Abstract: Techniques are provided herein to form semiconductor devices that include a gate cut formed after the formation of source/drain contacts. In an example, a semiconductor device includes a gate structure around or otherwise on a semiconductor region that extends from a source region to a drain region. Conductive contacts formed over the source and drain regions along a source/drain trench. The gate structure may be interrupted with a dielectric gate cut that further extends past the gate trench and into the source/drain trench where it can cut into one or more of the contacts. The contacts are formed before the gate cut to ensure complete fill of conductive material when forming the contacts. Accordingly, a liner structure on the conductive contacts is also broken by the intrusion of the gate cut and does not extend further up or down the sidewalls of the gate cut.

Abstract: Techniques are provided to form semiconductor devices that include one or more gate cuts having a layer of polymer material at edges of the gate cut. The polymer layer may be provided as a byproduct of the etching process used to form the gate cut recess through the gate structure, and can protect any exposed portions of the source or drain regions from certain subsequent processes. The gate structure may be interrupted between two transistors with a gate cut that extends through an entire thickness of the gate structure and includes a dielectric material to electrically isolate the portions of the gate structure on either side of the gate cut. The edges of the gate cut may be lined with a polymer layer that is also on any exposed portions of the source or drain regions that were exposed during the etching process used to form the gate cut recess.

Abstract: A query processing system is operable to determine a set of query rules that includes a minimum result set size rule. A query is received from a requesting entity. A size of a result set of the query is determined. Compliance data is determined based on determining whether the size of the result set complies with the minimum result set size rule. When the compliance data indicates the size of the result set complies with the minimum result set size rule, a query result for the query is generated based on the result set, and the query result is generated to the requesting entity. When the compliance data indicates the size of the result set does not comply with the minimum result set size rule: transmission of the query result to the requesting entity is foregone.

Abstract: An apparatus for securing to an outer surface of a segment of flexible pipe body, comprising an outer clamp portion around a region of flexible pipe body and comprising a plurality of outer body members each having an inner surface; and an inner clamp portion in an abutting relationship between the outer clamp portion and said flexible pipe body, comprising a plurality of inner body members each having an outer surface that comprises a mating region that has a shape that mates with a shape of a corresponding mating region of the inner surface of the outer clamp portion. Each mating region comprises at least one clamping surface region that in an imaginary plane that extends through and includes a primary axis of the pipe body, arranged oblique to the primary axis when the inner clamp portion is between the outer clamp portion and the pipe body.

Abstract: An autonomous vehicle includes a chassis for housing an aircraft ground contacting structure (GCS) and one or more GCS coupling and lifting mechanisms, GCS securing mechanisms, drivetrain, batteries and a sensor stack for performing autonomous navigation. Further, the vehicle incorporates multiple sensors, such as high-resolution machine vision cameras, GPS modules, Lidars, ultrasonic range sensors, and radars. The sensors deliver spatial perception capabilities to the vehicle and feed relevant data to onboard computing units to achieve location-based navigation, precision alignment with aircraft, obstacle detection and collision avoidance capabilities. A series of batteries deliver power to all components, including but not limited to, motors, electromechanical units, onboard computers, sensors and any other component requiring electrical input. External ports allow the vehicle to recharge batteries after each utilization cycle without replacement.

Abstract: An automated system and method provides for planning and response to disparate threats with combined kinetic (e.g., missile interceptor) and non-kinetic (e.g., cyber and electronic warfare) effects. The threat and effects inputs and the results of analysis tools that individually apply a single effect type to negate a threat vulnerability are normalized to a form and format ingestible by a Stochastic Math Model (SMM). The normalized inputs reflect the success/failure of the effect versus a threat vulnerability as a score, not a probability. The normalized results decompose a probability of defeat (Pdefeat) for an individual effect as a set of hierarchical parameters represented as probabilities.

Abstract: A control system for a work machine is disclosed that may include an input device, an electronic controller, and a joystick. The input device may be configured to transmit an electronic selection signal. The electronic controller may be in electronic communication with the input device, be configured to receive the electronic selection signal, and transmit an electronic configuration signal. The joystick may be in operative communication with at least one of a ground engaging member and a work implement and be configured to regulate movement of at least one of these. Further, the joystick may be in electronic communication with the electronic controller and may be configured to move along multiple axes. The joystick may be further configured to receive the electronic configuration signal and be selectively non-movable along at least one of its axes in response to this signal.

Abstract: An electronic control system for controlling movement of a work machine is disclosed. The control system may include a first and a second joystick, each of the first and second joysticks configured to move between a neutral and an operational position. Moreover a first and second resistive device may be operatively coupled to the first and second joysticks respectively. The first and second resistive devices may be configured to generate a resistive force to selectively retain the first and second joysticks in the operational position. Additionally, the control system may include a controller in communication with the first and second joysticks and the first and second resistive devices. The controller may transmit a first and second resistive force signal to activate one of the first and second resistive devices to generate the resistive force such that one of the first and second joysticks is retained in the operational position.

Abstract: A control system for a work machine is disclosed that may include an input device, an electronic controller, and a joystick. The input device may be configured to transmit an electronic selection signal. The electronic controller may be in electronic communication with the input device, be configured to receive the electronic selection signal, and transmit an electronic configuration signal. The joystick may be in operative communication with at least one of a ground engaging member and a work implement and be configured to regulate movement of at least one of these. Further, the joystick may be in electronic communication with the electronic controller and may be configured to move along multiple axes. The joystick may be further configured to receive the electronic configuration signal and be selectively non-movable along at least one of its axes in response to this signal.

Abstract: An electronic control system for controlling movement of a work machine is disclosed. The control system may include a first and a second joystick, each of the first and second joysticks configured to move between a neutral and an operational position. Moreover a first and second resistive device may be operatively coupled to the first and second joysticks respectively. The first and second resistive devices may be configured to generate a resistive force to selectively retain the first and second joysticks in the operational position. Additionally, the control system may include a controller in communication with the first and second joysticks and the first and second resistive devices. The controller may transmit a first and second resistive force signal to activate one of the first and second resistive devices to generate the resistive force such that one of the first and second joysticks is retained in the operational position.

Abstract: An automated system and method provides for planning and response to disparate threats with combined kinetic (e.g., missile interceptor) and non-kinetic (e.g., cyber and electronic warfare) effects. The threat and effects inputs and the results of analysis tools that individually apply a single effect type to negate a threat vulnerability are normalized to a form and format ingestible by a Stochastic Math Model (SMM). The normalized inputs reflect the success/failure of the effect versus a threat vulnerability as a score, not a probability. The normalized results decompose a probability of defeat (Pdefeat) for an individual effect as a set of hierarchical parameters represented as probabilities.

Abstract: The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.

Abstract: A method 10 of transmitting traffic in a communications network. The method comprises receiving client signal having a client bit rate and comprising traffic to be transmitted 12 and monitoring an indicator indicative of said client bit rate 12. The method further comprises setting a transmission bit rate at which to transmit the traffic 16. The transmission bit rate is set in dependence on said client bit rate. The method further comprises generating and transmitting a control signal arranged to cause a transmission apparatus to transmit the traffic at the transmission bit rate 18.

Abstract: The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.

Abstract: A method for unsupervised anomaly detection, which are algorithms that are designed to process unlabeled data. Data elements are mapped to a feature space which is typically a vector space d. Anomalies are detected by determining which points lies in sparse regions of the feature space. Two feature maps are used for mapping data elements to a feature apace. A first map is a data-dependent normalization feature map which we apply to network connections. A second feature map is a spectrum kernel which we apply to system call traces.

Abstract: The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.