Patents by Inventor Andrew B. Onderdonk

Andrew B. Onderdonk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150203900
    Abstract: The specification relates generally to methods of detecting, diagnosing, and/or identifying pathogens, e.g., infectious disease pathogens and determining their drug sensitivity and appropriate methods of treatment. This invention also relates generally to methods of monitoring pathogen infection in individual subjects as well as larger populations of subjects.
    Type: Application
    Filed: March 9, 2015
    Publication date: July 23, 2015
    Inventors: Deborah Hung, Amy Barczak, James Gomez, Andrew B. Onderdonk, Lisa Cosimi, Rob Nicol, Mark Borowsky
  • Publication number: 20130190196
    Abstract: The specification relates generally to methods of detecting, diagnosing, and/or identifying pathogens, e.g., infectious disease pathogens and determining their drug sensitivity and appropriate methods of treatment. This invention also relates generally to methods of monitoring pathogen infection in individual subjects as well as larger populations of subjects.
    Type: Application
    Filed: February 24, 2011
    Publication date: July 25, 2013
    Inventors: Andrew B. Onderdonk, Amy Barczak, Deborah Hung, James Gomez, Lisa Cosimi, Rob Nicol, Mark Borowsky
  • Patent number: 7456220
    Abstract: The invention relates to immunomodulatory compositions and related methods. The immunomodulatory compositions of a formula disclosed herein are useful for the prevention of sepsis and the treatment and prevention of diseases associated with inflammation and/or NOS.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: November 25, 2008
    Assignees: Genzyme Corporation, The Brigham and Women's Hospital, Inc.
    Inventors: Pericles Calias, Robert J. Miller, Andrew B. Onderdonk, Arthur O. Tzianabos
  • Patent number: 7083777
    Abstract: A pharmaceutical composition consisting of identical repeating units, each unit having a charge motif composed of a positively charged free amino moiety and a negatively charged moiety, wherein the positively charged free amino moiety and the negatively charged moiety of each charge motif are separated by at least one neutral amino acid, and wherein the positively charged free amino moiety of one of the charge motifs is separated by a distance of at least 8 amino acids from the positively charged amino moiety of another charge motif, and a pharmaceutically acceptable carrier. Said pharmaceutical composition is useful for inducing IL-2, activating T cells to produce a T helper 1 cytokine profile, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and/or protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: August 1, 2006
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Arthur O. Tzianabos, Dennis L. Kasper, Andrew B. Onderdonk, Ying Wang
  • Patent number: 7026285
    Abstract: Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. The methods of the invention are accomplished using an immunomodulator which is a polymer having at least two repeating charge motifs separated by at least a certain minimum distance.
    Type: Grant
    Filed: May 19, 2004
    Date of Patent: April 11, 2006
    Assignee: The Bingham and Women's Hospital, Inc.
    Inventors: Arthur O. Tzianabos, Dennis L. Kasper, Andrew B. Onderdonk, Julia Ying Wang
  • Publication number: 20040209818
    Abstract: Methods and products for inducing IL-2 secretion, inducing IL-10 secretion, activating T cells, suppressing IgG antibody response to specific antigen, promoting allograft survival, reducing postoperative surgical adhesion formation, and protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. The methods of the invention are accomplished using an immunomodulator which is a polymer having at least two repeating charge motifs separated by at least a certain minimum distance.
    Type: Application
    Filed: May 19, 2004
    Publication date: October 21, 2004
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Arthur Tzianabos, Dennis L. Kasper, Andrew B. Onderdonk, Ying Wang
  • Patent number: 5700787
    Abstract: Methods and products for protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. Methods for forming immunomodulators and pharmaceutical compositions relating thereto also are provided. The products useful in the invention are polysaccharides including a repeat unit having a positively charged free amino group and a negatively charged group. The preferred polysaccharide is B. fragilis capsular polysaccharide A.
    Type: Grant
    Filed: July 14, 1995
    Date of Patent: December 23, 1997
    Assignee: Brigham & Women's Hospital, Inc.
    Inventors: Arthur O. Tzianabos, Andrew B. Onderdonk, Dennis L. Kasper
  • Patent number: 5679654
    Abstract: Methods and products for protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. Methods for forming immunomodulators and pharmaceutical compositions relating thereto also are provided. The products useful in the invention are polysaccharides including a repeat unit having a positively charged free amino group and a negatively charged group. The preferred polysaccharide is B. fragilis capsular polysaccharide A.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: October 21, 1997
    Assignee: Brigham & Women's Hospital, Inc.
    Inventors: Arthur O. Tzianabos, Andrew B. Onderdonk, Dennis L. Kasper