Abstract: An aerodynamic unit is configured for attachment onto a roof of a road vehicle, so that air passes over the unit during forward movement of the road vehicle. The unit has a first end for positioning distal to a rear end of a vehicle roof, and a second end for positioning proximal a rear end of a vehicle roof. The unit includes an inclined guide portion which decreases in height in a direction towards the trailing end of the unit. The unit also includes a flow director at or near the leading end of the aerodynamic unit, for directing air flow to the guide portion. The flow director is configured to have a height increasing in a direction from the leading end towards the trailing end. The unit may include vortex generators protruding from the guide portion. A fin may extend along each side of the unit in a direction between the trailing end and the leading end.

Abstract: An aerodynamic unit is configured for attachment onto a roof of a road vehicle, so that air passes over the unit during forward movement of the road vehicle. The unit has a first end for positioning distal to a rear end of a vehicle roof, and a second end for positioning proximal a rear end of a vehicle roof. The unit includes an inclined guide portion which decreases in height in a direction towards the trailing end of the unit. The unit also includes a flow director at or near the leading end of the aerodynamic unit, for directing air flow to the guide portion. The flow director is configured to have a height increasing in a direction from the leading end towards the trailing end. The unit may include vortex generators protruding from the guide portion. A fin may extend along each side of the unit in a direction between the trailing end and the leading end.

Abstract: An aerodynamic unit is attached onto a roof of a road vehicle so that air passes over the unit during forward movement of the road vehicle. The unit has a first end for positioning distal to a rear end of a vehicle roof and a second end for positioning proximal a rear end of a vehicle roof. The unit includes an inclined guide portion which decreases in height in a direction towards the trailing end of the unit. The unit also includes a flow director, which directs air flow to the guide portion, disposed at or near the leading end of the aerodynamic unit. The flow director has a height increasing in a direction from the leading end towards the trailing end. The unit may include vortex generators protruding from the guide portion. A fin may extend along each side of the unit in a direction between the trailing end and the leading end.

Abstract: An aerodynamic unit is attached onto a roof of a road vehicle so that air passes over the unit during forward movement of the road vehicle. The unit has a first end for positioning distal to a rear end of a vehicle roof and a second end for positioning proximal a rear end of a vehicle roof. The unit includes an inclined guide portion which decreases in height in a direction towards the trailing end of the unit. The unit also includes a flow director, which directs air flow to the guide portion, disposed at or near the leading end of the aerodynamic unit. The flow director has a height increasing in a direction from the leading end towards the trailing end. The unit may include vortex generators protruding from the guide portion. A fin may extend along each side of the unit in a direction between the trailing end and the leading end.

Abstract: The present invention provides compositions and methods for the treatment of multiple sclerosis. Among others, the invention provides compositions of immunodominant peptides of myelin basic protein encapsulated in mannosylated liposomes. In a specific embodiment, the compositions comprise mylein basic protein (MBP) peptides MBP(46-62), MBP(124-139), and MBP(147-170).

Abstract: A composition for the co-delivery to a cell of a nucleic acid and an assistor protein, comprising vesicles, nucleic acid and protein, wherein the nucleic acid operatively encodes an antigenic protein or portion thereof which shares at least one epitope with the assistor protein, the composition comprising said nucleic acid and said assistor protein associated with the same vesicles as one another. A preferred embodiment is a composition comprising liposomes formed from liposome forming materials and, associated with the liposomes, nucleic acid operatively encoding an antigenic protein and an assistor protein, wherein the assistor protein shares at least one epitope with the antigenic protein. The composition is for use as a vaccine and provides improved immune response compared to non-vesicular compositions, or mixtures of liposomes some of which are associated with nucleic acid and some of which are associated with assistor protein.

Abstract: The invention provides a method for designing protein immunogen, which comprises (a) modifying the amino acid sequence of the immunogen, and (b) determining whether the T-helper (Th) cell response to the modified immunogen is of the Th1 type or the Th2 type. The method is useful in identifying immunogens for use in immunotherapy of diseases. For example, chronic hepatitis is believed to be associated with a Th2-dominated response which fails to clear the virus, and switching the Th response to a Th1 response by administration of an immunogen that induces a Th1 response may help in clearing the virus.