Abstract: System and method to produce an anonymized cohort, members of the cohort having less than a predetermined risk of re-identification. The system includes a user-facing communication interface to receive an anonymized cohort request comprising traits to include in members of the cohort; a data source-facing communication channel to query a data source, to find anonymized records that possess at least some of the requested traits; and a processor programmed to carry out the instructions of: forming a dataset from at least some of the anonymized records; calculating a risk of re-identification of the anonymized records in the dataset based upon the data query; perturbing anonymized records in the dataset that exceed a predetermined risk of re-identification, until the risk of re-identification is not greater than the pre-determined threshold, to produce the anonymized cohort; and providing, via a user-facing communication channel, the anonymized cohort.

Abstract: The invention provides a shower recess comprising: a shower outlet (3) for showering a person; a partition (2) attached at least to a wall (4) for keeping water within the shower recess; a shower tap (6) installed on the wall (4) for regulating at least the flow of water through the shower outlet; wherein the shower tap (6) is positioned substantially in line with the partition (2) and within an opening in the partition shaped to accommodate the shower tap (6), and the shower tap (6) comprises a handle (20b) on the shower recess side of the partition for operation when the person is inside the recess and a handle (20a) on the outer side of the partition for operation when the person is outside the recess.

Abstract: The invention relates to the field of gene transfer, and in particular to the use of adenoviral vectors of serotype Ad49 for gene delivery to vascular tissue.

Abstract: A system, method and computer readable memory for determining journalist risk of a dataset using population equivalence class distribution estimation. The dataset may be a cross-sectional data set or a longitudinal dataset. The determine risk of identification can be determined and used in de-identification process of the dataset.

Abstract: In longitudinal datasets, it is usually unrealistic that an adversary would know the value of every quasi-identifier. De-identifying a dataset under this assumption results in high levels of generalization and suppression as every patient is unique. Adversary power gives an upper bound on the number of values an adversary knows about a patient. Considering all subsets of quasi-identifiers with the size of the adversary power is computationally infeasible. A method is provided to assess re-identification risk by determining a representative risk which can be used as a proxy for the overall risk measurement and enable suppression of identifiable quasi-identifiers.

Abstract: In one aspect a drug delivery device may include a reservoir containing a liquid drug formulation and a microneedle assembly in fluid communication with the reservoir. The microneedle assembly may include a plurality of microneedles, with each microneedle defining an open channel for receiving a drug formulation. The open channel may have a normalized hydraulic radius ranging from about 0.1 to about 0.8. The open channel may also have a liquid-to-solid interfacial energy and a liquid-to-vapor interfacial energy when a fixed volume of the drug formulation is received therein. In addition, the drug formulation and a cross-sectional geometry of the open channel may be selected and configured such that the liquid-to-solid energy exceeds the liquid-to-vapor energy as the length of the fixed volume of drug formulation is increased within the open channel.

Abstract: The invention provides a shower recess comprising: a shower outlet (3) for showering a person; a partition (2) attached at least to a wall (4) for keeping water within the shower recess; a shower tap (6) installed on the wall (4) for regulating at least the flow of water through the shower outlet; wherein the shower tap (6) is positioned substantially in line with the partition (2) and within an opening in the partition shaped to accommodate the shower tap (6), and the shower tap (6) comprises a handle (20b) on the shower recess side of the partition for operation when the person is inside the recess and a handle (20a) on the outer side of the partition for operation when the person is outside the recess.

Abstract: The present invention provides a method of treating or preventing pulmonary arterial hypertension in a subject in need thereof by administering to the subject an inhibitor of miR-145 expression or activity. Pharmaceutical compositions and kits comprising miR-145 inhibitors for treating pulmonary arterial hypertension are also disclosed.

Abstract: A drug delivery device is disclosed that may include a skin penetrating assembly having a support defining an upper surface and a lower surface. The skin penetrating assembly may also include a plurality of skin penetrating members extending outwardly from the lower surface. Each skin penetrating member may define a channel for receiving a drug formulation. In addition, the device may include a reservoir positioned adjacent to the upper surface of the support for initially retaining the drug formulation. The reservoir may include a top surface and a bottom surface and may define a plurality of passages extending between the top and bottom surfaces. The passages may be configured such that the drug formulation is retained within the passages against gravity.

Abstract: Special purpose machines and methods of transforming raw disclosure information into a particularly structured dataset or database that can optimally store and present disclosure information for processing that complies with specific rules regarding securities offerings are described. Raw disclosure information provided by an issuer is processed, parsed, and strategically partitioned within a database.

Abstract: The invention relates to the field of gene transfer, and in particular to the use of adenoviral vectors of serotype Ad49 for gene delivery to vascular tissue.

Abstract: The present invention includes a microneedle assembly having a support that includes a first surface and a second surface, the second surface further including a slanted surface. A plurality of microneedles are provided which project outwardly from the second surface of the support. A pathway through the microneedle assembly is formed and includes an aperture extending between the first surface of the support and the second surface of the support, a channel disposed on the exterior surface of at least one microneedle, the channel having a surface, the channel being in alignment with at least a portion of the aperture to form a junction through which fluids may pass.

Abstract: An initial SIP message is sent to establish a first SIP communication session from a first SIP device. The initial SIP message is sent via a first of a plurality of session managers to a second SIP device. After receiving the initial SIP message at the second SIP device and before ending the first SIP communication session, either the first or second SIP device sends a second SIP message. The second SIP message is sent to the first of the plurality of session managers. Either the first or second SIP devices detects that a response SIP message to the sent second SIP message was not received within a defined time period. In response to detecting that the SIP response message was not received within the defined time period, either the first or second SIP device resends the second SIP message to a second one of the plurality of session managers.

Abstract: A system and method for authenticating a layer 7 client application (application layer) based on a layer 2 (data link layer) or a layer 3 (network layer) authentication is provided. A request to authenticate to a network is received from a communication device. The request to authenticate to the network is for a layer 2 or layer 3 authentication. The communication device is authenticated to the network based on having the necessary credentials. A request is received to authenticate a layer 7 client application running on the communication device. The layer 7 client application running on the communication device requires a layer 7 authentication. The layer 7 client application running on the communication device is authenticated based on the layer 2 or layer 3 authentication.

Abstract: A machine includes a base, a main housing that is freely rotatable and supported on the base. The main housing includes a generally horizontal surface. The machine also includes a drum mounted on said main housing, a boom extending from said main housing, a bucket operatively connected to and supported by the boom, a wire rope extending between the drum and the bucket for movement of the bucket, a fairlead disposed on the main housing along a path of the wire rope. The wire rope passes through the fairlead between the drum and the bucket. A dynamic dampening mechanism is disposed on the fairlead, the dynamic dampening mechanism including a dampening fluid having a variable viscosity in response to an electrical current applied thereto.

Abstract: Session Manager anti-looping creates a model that is an effective barrier to looping, efficiently identifying a loop condition by maintaining temporary individual call counters for header sets within temporal parameters and terminating the loop condition upon detection. The system provides an administrator with adjustable parameters for loop detection count and loop detection interval, thereby allowing protection against loop conditions, both inadvertent and intentional.

Abstract: A system includes a storage device for storing details of a plurality of reservations of a hospitality establishment. A particular reservation includes a registered device setting for affecting behavior of a computer network at the hospitality establishment toward a user device having a specified device identifier. The system further includes a clock unit for tracking time, and a system controller coupled to the computer network and having access to the storage device and the clock unit. The system controller automatically configures one or more network components of the computer network when a start time of the particular reservation is reached in order to activate the registered device setting, and automatically configures the one or more network components when an end time of the particular reservation is reached in order to deactivate the registered device setting.

Abstract: The present invention provides a method of treating or preventing pulmonary arterial hypertension in a subject in need thereof by administering to the subject an inhibitor of miR-145 expression or activity. Pharmaceutical compositions and kits comprising miR-145 inhibitors for treating pulmonary arterial hypertension are also disclosed.

Abstract: A system and method for authenticating a layer 7 client application (application layer) based on a layer 2 (data link layer) or a layer 3 (network layer) authentication is provided. A request to authenticate to a network is received from a communication device. The request to authenticate to the network is for a layer 2 or layer 3 authentication. The communication device is authenticated to the network based on having the necessary credentials. A request is received to authenticate a layer 7 client application running on the communication device. The layer 7 client application running on the communication device requires a layer 7 authentication. The layer 7 client application running on the communication device is authenticated based on the layer 2 or layer 3 authentication.