Abstract: Methods and devices are provided for simultaneously amplifying a plurality of sample wells for a predetermined amount of amplification, detecting whether amplification has occurred in a first set of the wells, amplifying for an additional amount of amplification and detecting whether amplification has occurred in a second set of the wells. Methods are also provided for analyzing a target nucleic acid sequence using melt curves that were generated in a plurality of amplification cycles.

Abstract: Melanin is an effective absorber of light and is able to dissipate the majority of light absorbed by the pigment. This can mask the absorbance of biomolecules of interest such as hemoglobin when imaging skin tissue. Melanin is the primary determinant of skin color which can vary between individuals as well as within individuals (due to the presence of portions of skin with more or less pigment as well as features such as freckles and moles). Described herein are methods for compensating for melanin absorption at the pixel level of an image, thereby allowing for more accurate imaging of concentration and distribution of biomolecules of interest in a tissue portion.

Abstract: Melanin is an effective absorber of light and is able to dissipate the majority of light absorbed by the pigment. This can mask the absorbance of biomolecules of interest such as hemoglobin when imaging skin tissue. Melanin is the primary determinant of skin color which can vary between individuals as well as within individuals (due to the presence of portions of skin with more or less pigment as well as features such as freckles and moles). Described herein are methods for compensating for melanin absorption at the pixel level of an image, thereby allowing for more accurate imaging of concentration and distribution of biomolecules of interest in a tissue portion.

Abstract: An autonomous robot and methods are provided for lifting and stacking packages, such as on a shelf in a warehouse. The robot comprises a base, an elevator assembly that raises and lowers an elevator platform, an engagement mechanism for attaching the robot to a shelf, and steerable drive mechanisms for driving the robot in any direction (e.g. both forward and laterally) on a warehouse floor. The robot is navigated to a storage location of a package. The robot is driven laterally towards the shelf without rotating the robot or elevator platform, and is then clamped to the shelf. The elevator platform is then raised to the height of the package. The package is moved from the storage location to the elevator platform with a gantry.

Abstract: A system and method for achieving vertical navigation by using a satellite based navigation system exemplified by a GPS system and implementing the vertical navigation features in an autopilot unit interfaced to the satellite based navigation system. The autopilot reads waypoint information output from the satellite navigation system and receives VNAV altitudes and other commands from the pilot. The autopilot then performs VNAV calculations and guidance in accordance with the VNAV program. VNAV setup and progressive status are displayed on an economical small screen autopilot display. Modes are disclosed for exemplary GPS direct to waypoint VNAV, waypoint transition VNAV, multiple waypoint VNAV and other VNAV modes. Safety limits may be imposed on the VNAV program.

Abstract: Provided herein are methods for inhibiting expression of DOHH in a cell, and for inhibiting hypusination of eIF5A in a cell, the methods comprising contacting a cell with a miRNA or a nucleic acid molecule encoding the miRNA, wherein the miRNA binds to the 3?UTR of the DOHH mRNA and wherein binding results in a reduction in DOHH expression. Also provided are methods for reducing cellular proliferation and for treating diseases associated with abnormal cellular proliferation.

Abstract: An inkjet printhead having at least one internal electrode in contact with ink in use, wherein region(s) of the electrode surface are covered by an electrically insulating organic material that has been deposited thereon by electrophoresis.

Abstract: An inkjet printhead having at least one internal electrode in contact with ink in use, wherein region(s) of the electrode surface are covered by an electrically insulating organic material that has been deposited thereon by electrophoresis.

Abstract: A computer readable medium includes executable instructions to receive a query, receive information about the identity of the query requester, send the query to at least one data source, receive data from the at least one data source, and apply confidentiality criteria to the data based on a set of rules to produce masked confidential data. The masked confidential data is returned in a report in response to the query.

Abstract: A closure device for closing a bag, includes a rail assembly having a first and a second rail, each rail having a proximal and a distal end, the respective proximal rail ends being operably coupled together and the respective distal rail ends being openable to define an aperture between the first and a second rails, and a lock ring, the lock ring having a bore defined therethrough, the rail assembly being disposable in the bore, the lock ring being readily shiftable along a dimension of the rail assembly, the dimension extending from proximate the proximal end of the rail assembly to proximate the distal end of the rail assembly. A method of forming a closure device id further included.

Abstract: An ocular light therapy device including a housing with a light passage opening, a reflective surface supported by the housing and a light source in the housing, the light source selected to emit light therefrom and positioned to direct the light toward the reflective surface such that light emitted from the light source reflects from the reflective surface through the light passage opening for administration of light therapy.

Abstract: A request requesting a real time clock (RTC) value in a communications network is sent from a network element to a management system via a data communications network. The time taken from the sending of the request to the receipt of the RTC value is compared with a predetermined maximum and, if less than or equal to the maximum, the network element RTC is updated. If above the maximum, the RTC value is discarded, and a fresh request is sent. The received acceptable RTC value may be corrected by subtracting either the minimum transmission time or half the actual transmission time.

Abstract: A communications network determines for itself its own network topology, that is, the identity and interconnection of nodes comprising the network. The network comprises a plurality of nodes each having at least one port. The ports are interconnected in accordance with the network topology in which communication traffic is conveyed over the network via the interconnected ports. Each port is arranged to transmit first information within the communication traffic including the identity of the port (Section trace identity) from which the communication traffic originates. Second information is transmitted between nodes identifying which first information identity relates to which node and which port. A processor is operative for determining for each node from the first and second information the identity of adjacent nodes and the identity of the ports to which its ports are connected.

Abstract: A first multi protocol label switching (MPLS) enabled Internet Protocol (IP) data network is able to transmit data to a second MPLS enabled IP network via a legacy optical network, which would not otherwise be able to handle the user network interface (UNI) protocols required to be used within an MPLS network environment, by means of configuring the legacy optical network and its traditional network management system (TNMS) so that they simulate or emulate an MPLS enabled optical network. The simulation/emulation of an MPLS network is performed as follows: when a first legacy network element (NE) receives a connection request (a UNI request) from the MPLS network under a UNI protocol, the UNI request is passed to the TNMS, which then sets the required connection across the legacy network via a second edge NE to an NE of the second IP network.

Abstract: To perform non-blocking cross connections in a high data rate switch operative for switching a synchronous data stream where the data is arranged in groups, the bits of the data groups are spread into subsets of one or more bits and the subsets switched individually across lower bit rate switches. At the destination the subsets are recombined. The bit spreader and recombiner may be arranged on the switch card or at the source and destination interfaces respectively. A protection switch can provide 1:N protection and an XOR function can be incorporated with the protection switch to provide 1:N protection without signalling from the destination interface to the source interface.

Abstract: A beverage dispensing apparatus being formed so as in use to provide a vortex motion in the mass of beverage flowing through the apparatus. In the vortexial flow, a low pressure area is produced at the center of the vortex so that the pressure in that region falls below equilibrium pressure and thus results in gas separating out from the liquid beverage. Since the gas breakout is achieved without the need for a flow restrictor, the pressure drop associated with these devices does not occur. Consequently, the beverage may enter the apparatus at a lower pressure. Moreover it has been found that a high quality head is formed on the draught beverage dispensed from the apparatus of the invention.

Abstract: A beverage dispensing apparatus being formed so as in use to provide a vortex motion in the mass of beverage flowing through the apparatus. In the vortexial flow, a low pressure area is produced at the center of the vortex so that the pressure in that region falls below equilibrium pressure and thus results in gas separating out from the liquid beverage. Since the gas breakout is achieved without the need for a flow restrictor, the pressure drop associated with these devices does not occur. Consequently, the beverage may enter the apparatus at a lower pressure. Moreover it has been found that a high quality head is formed on the draught beverage dispensed from the apparatus of the invention.

Abstract: A baking utensil so shaped as to mold within bread dough baked upon it one or more buns, each with a recess to retain a weiner, bratwurst, frankfurter, processed meat link, hamburger or other cooked meat product.