Abstract: Presented herein are systems and methods for constructing antibody libraries using machine learning to inform sequence selection for inclusion in the library. The techniques include (i) the training and use of machine learning models and statistical models to predict biophysical and biochemical properties from sequences, and (ii) the training and use of machine learning models for predicting developability from sequences, and for generating novel sequences. In certain embodiments, the systems and methods generate libraries of antibodies (and/or antibody-encoding polynucleotides) by specifically designing the libraries with directed sequence and/or length diversity. The resulting libraries are useful, for example, in the development of therapeutic agents.

Abstract: A lift device is disclosed that can be used to provide vertical lift to an aircraft or other vehicle. The lift device can include a fan that produces an airflow and a vane box that can direct the airflow. In one form the fan can be oriented at an angle relative to a reference plane in the aircraft. In another form the vane box can be oriented at an angle. The vane box can be structured to provide a maximum flow area between an aft flow vector and a forward flow vector.

Abstract: A lift device is disclosed that can be used to provide vertical lift to an aircraft or other vehicle. The lift device can include a fan that produces an airflow and a vane box that can direct the airflow. In one form the fan can be oriented at an angle relative to a reference plane in the aircraft. In another form the vane box can be oriented at an angle. The vane box can be structured to provide a maximum flow area between an aft flow vector and a forward flow vector.

Abstract: Embodiments of the present invention include a system, e.g., for a short takeoff and vertical landing (STOVL) aircraft. The system includes a power generator, such as a gas turbine engine; a lift fan powered by the power generator; and includes two or more nozzles in fluid communication with the lift fan.

Abstract: The present invention relates to digital rights management and more particularly to a system and method for securely publishing and controlling the usage of digital content. Advantageously a publisher or owner of digital content or of a copyright work can distribute securely that work in a secure digital form.

Abstract: The present invention relates to digital rights management and more particularly to a system and method for securely publishing and controlling the usage of digital content. Advantageously a publisher or owner of digital content or of a copyrights work can distribute securely that work in a secure digital form.