Abstract: An intra-uterine device for treating post-partum hemorrhage (PPH) is described, along with an applicator system. In embodiments, the PPH device is comprised of a mesh pouch that is filled with a plurality of sponges. Each sponge is designed to expand upon absorption of fluids, such as blood. The collective expansion of the sponges within the mesh pouch causes the PPH device to expand within a patient's uterus, thus applying pressure to stanch blood flow. The PPH device is loaded into an applicator which is then inserted into a patient, and a corresponding plunger is used to deploy the PPH device. Following completion of treatment, the PPH device may be removed using a removal strand attached to the pouch that is exposed outside of the patient.

Abstract: An intra-uterine device for treating post-partum hemorrhage (PPH) is described, along with an applicator system. In embodiments, the PPH device is comprised of a mesh pouch that is filled with a plurality of sponges. Each sponge is designed to expand upon absorption of fluids, such as blood. The collective expansion of the sponges within the mesh pouch causes the PPH device to expand within a patient's uterus, thus applying pressure to stanch blood flow. The PPH device is loaded into an applicator which is then inserted into a patient, and a corresponding plunger is used to deploy the PPH device. Following completion of treatment, the PPH device may be removed using a removal strand attached to the pouch that is exposed outside of the patient.

Abstract: Embodiments herein provide hemostatic compositions comprising a plurality of liquid-expandable articles arranged on a backing material. In general, embodiments include methods for treating hemorrhagic injuries. More specifically, there is provided a method to effect rapid hemostatic response and control hemorrhage by introducing a hemostatic composition into a bleeding wound cavity. An embodiment also provides a method of preparing or manufacturing such a hemostatic composition.

Abstract: An intra-uterine device for treating post-partum hemorrhage (PPH) is described, along with an applicator system. In embodiments, the PPH device is comprised of a mesh pouch that is filled with a plurality of sponges. Each sponge is designed to expand upon absorption of fluids, such as blood. The collective expansion of the sponges within the mesh pouch causes the PPH device to expand within a patient's uterus, thus applying pressure to stanch blood flow. The PPH device is loaded into an applicator which is then inserted into a patient, and a corresponding plunger is used to deploy the PPH device. Following completion of treatment, the PPH device may be removed using a removal strand attached to the pouch that is exposed outside of the patient.

Abstract: Embodiments provide a tourniquet that may be used as a daily wear belt. A tourniquet belt may include an elongate belt having a first end and a second free end; a securing element coupled to the elongate belt at the first end of the elongate belt; and a separate tightening element coupled to the elongate belt, wherein the tightening element is selectively actuable to tighten or loosen the tourniquet belt.

Abstract: Embodiments herein provide hemostatic compositions comprising a plurality of liquid-expandable articles arranged on a backing material. In general, embodiments include methods for treating hemorrhagic injuries. More specifically, there is provided a method to effect rapid hemostatic response and control hemorrhage by introducing a hemostatic composition into a bleeding wound cavity. An embodiment also provides a method of preparing or manufacturing such a hemostatic composition.

Abstract: Provided herein are self-expanding wound dressings that include a first outer layer, a second outer layer, and a liquid-expandable layer disposed between the first outer layer and the second outer layer, wherein the liquid-expandable layer includes a plurality of liquid-expandable articles retained by a substrate, wherein the plurality of liquid-expandable articles expand to form expanded articles upon contact with a liquid. Also provided is a method of treating an individual having a bleeding wound, the method including applying a self-expanding wound dressing to the wound. Also provided are methods of manufacturing a wound dressing, the methods including forming an absorbent material into a plurality of liquid-expandable articles, coupling the plurality of liquid-expandable articles to a substrate to form a liquid-expandable layer, and positioning the liquid-expandable layer between a first outer layer and a second outer layer to form the wound dressing.

Abstract: Embodiments provide a tourniquet that may be used as a daily wear belt. A tourniquet belt may include an elongate belt having a first end and a second free end; a securing element coupled to the elongate belt at the first end of the elongate belt; and a separate tightening element coupled to the elongate belt, wherein the tightening element is selectively actuable to tighten or loosen the tourniquet belt.

Abstract: Provided herein are vascular compression devices that may be used to apply pressure to an area of the body of a subject near or at a wound site following an injury or procedure (e.g., a catheterization procedure) involving one or more veins and/or arteries. The vascular compression device may include a plate having a concave face and an opposing face; a first strut and a second strut extending from and disposed adjacent opposite edges of the opposing face of the plate; and a pressure bar spaced away from the plate by the first and second struts and spanning a distance between the first and second struts.

Abstract: Provided herein are self-expanding wound dressings that include a first outer layer, a second outer layer, and a liquid-expandable layer disposed between the first outer layer and the second outer layer, wherein the liquid-expandable layer includes a plurality of liquid-expandable articles retained by a substrate, wherein the plurality of liquid-expandable articles expand to form expanded articles upon contact with a liquid. Also provided is a method of treating an individual having a bleeding wound, the method including applying a self-expanding wound dressing to the wound. Also provided are methods of manufacturing a wound dressing, the methods including forming an absorbent material into a plurality of liquid-expandable articles, coupling the plurality of liquid-expandable articles to a substrate to form a liquid-expandable layer, and positioning the liquid-expandable layer between a first outer layer and a second outer layer to form the wound dressing.

Abstract: Embodiments provide a medical device in the form of an applicator for applying a medical composition to a patient. The applicator includes a body, a tip, and a delivery mechanism. The body defines a storage chamber for the medical composition and has an opening for deploying the medical composition from the storage chamber. The tip covers the opening and has a closed state wherein the tip maintains the medical composition in the storage chamber and an open state wherein the medical composition can be deployed through the opening and the tip.

Abstract: Embodiments herein provide hemostatic compositions comprising a plurality of liquid-expandable articles arranged on a backing material. In general, embodiments include methods for treating hemorrhagic injuries. More specifically, there is provided a method to effect rapid hemostatic response and control hemorrhage by introducing a hemostatic composition into a bleeding wound cavity. An embodiment also provides a method of preparing or manufacturing such a hemostatic composition.

Abstract: It is a general object of the invention to provide a method of effecting repair or replacement or supporting a section of a body tissue using tropoelastin, preferably crosslinked tropoelastin and specifically to provide a tropoelastin biomaterial suitable for use as a stent, for example, a vascular stent, or as conduit replacement, as an artery, vein or a ureter replacement. The tropoelastin biomaterial itself can also be used as a stent or conduit covering or coating or lining.