Abstract: Devices, systems, and methods for separating solids from liquids are disclosed. A vessel includes an inlet, a carrier liquid outlet, a product outlet, a purifying section, and a heater. The inlet directs a slurry into the purifying section. The slurry comprises particles of a solid and a carrier liquid. The purifying section preferentially drives the particles of the solid towards a heating zone of the purifying section versus the carrier liquid. This displaces a first portion of the carrier liquid away from the heating zone of the purifying section. The heater heats the slurry. The carrier liquid outlet drives a majority of the carrier liquid out of the vessel. The product outlet is adjacent to the heating zone of the purifying section.

Abstract: The invention relates to cocrystals comprising a substituted 2-oxo-1-pyrrolidinyl triazole of formula (I) and a carboxylic acid of formula (II).

Abstract: The invention is directed to compounds of formula (I), and salts thereof. The compounds are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: The invention is directed to compounds of formula (I), and salts thereof. The compounds are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: A process for forming a solid product or products is disclosed. The process is provided with n desublimating exchangers. An exchanger E1 being associated with a first exchanger and an exchanger En being associated with an nth exchanger, n representing the number of exchangers. The n exchangers comprise at least one direct-contact exchanger comprising a contact fluid. A process fluid is passed through the n exchangers in order from E1 through En. The process fluid comprises a product component or components. The solid product or products form from the product component or components in the plurality of exchangers by desublimation. The solid product or products are separated from the process fluid. In this manner, a solid product or products is formed.

Abstract: A method for preventing fouling of a demister is disclosed. A process fluid is provided into a vessel. A gas is provided to a gas inlet of the vessel. The gas comprises a component that desublimates, crystallizes, solidifies, reacts, or a combination thereof, in the process fluid, forming a first solid. The gas is passed through the process fluid, the component of the gas forming the first solid, resulting in a component-depleted gas. The component-depleted gas is passed out of the process fluid, causing splashing or spurting of the process fluid and the first solid. The diverter section is provided between the demister and the gas inlet, the diverter section comprising a physical obstruction preventing the process fluid and the first solid from splashing or spurting onto the demister. In this manner, fouling of the demister is prevented.

Abstract: Condensable vapors such as carbon dioxide are separated from light gases in a process stream. The systems and methods employ a circulating fluidized particle bed cooled by an out-bed heat exchanger to desublimate the solid form of condensable vapors from the process stream. Gas and solids may be sorted in a separator, and the solids may then be subcooled in a heat exchanger. The condensable vapors may be condensed on the bed particles or in the heat exchanger while the light gases from the process stream, which are not condensed, form a separated light-gas stream.

Abstract: A magnetic stanchion connector assembly that includes a first stanchion connector and a second stanchion connector, wherein the first and second stanchion connectors each have a rear face operably configured to selectively removably couple with a belt connector and a second belt connector of a stanchion connection assembly in stanchion tongue-and-groove locking configuration. The first and second stanchion connectors each have a magnet retained thereon of opposite polarities and disposed proximal to a front face of each stanchion connector, wherein the first and second stanchion connectors are operably configured to magnetically couple together quickly and effectively and adapted for use with conventional belt connectors on a stanchion connection assembly.

Abstract: An air-sparged hydrocyclone for separating a vapor from a carrier gas is disclosed. The cyclone comprises a porous sparger covered by an outer gas plenum. A cryogenic liquid is injected to a tangential feed inlet at a velocity that induces a tangential flow and a cyclone vortex in the air-sparged hydrocyclone. The carrier gas is injected into the cyclone through the porous sparger. The vapor dissolves, condenses, desublimates, or a combination thereof, forming a vapor-depleted carrier gas and a vapor-enriched cryogenic liquid. The vapor-depleted carrier gas is drawn through a vortex finder and the vapor-enriched cryogenic liquid is drawn through an apex nozzle outlet. In this manner, the vapor is removed from the carrier gas.

Abstract: Compounds of formula (I) and salts thereof: wherein R1, R2, R3, a, X1, X2, X3, X4, and X5 are as defined hereinbefore. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain containing proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.

Abstract: Devices, systems, and methods for separating solids from liquids are disclosed. A vessel includes an inlet, a carrier liquid outlet, a product outlet, a purifying section, and a heater. The inlet directs a slurry into the purifying section. The slurry comprises particles of a solid and a carrier liquid. The purifying section preferentially drives the particles of the solid towards a heating zone of the purifying section versus the carrier liquid. This displaces a first portion of the carrier liquid away from the heating zone of the purifying section. The heater heats the slurry. The carrier liquid outlet drives a majority of the carrier liquid out of the vessel. The product outlet is adjacent to the heating zone of the purifying section.

Abstract: A hydrocyclone for separating a vapor from a carrier gas is disclosed. The hydrocyclone comprises one or more nozzles. A cryogenic liquid is injected to a tangential feed inlet at a velocity that induces a tangential flow and a cyclone vortex in the hydrocyclone. The carrier gas is injected into the cryogenic liquid, causing the vapor to dissolve, condense, desublimate, or a combination thereof, forming a vapor-depleted carrier gas and a vapor-enriched cryogenic liquid. The vapor-depleted carrier gas is drawn through a vortex finder and the vapor-enriched cryogenic liquid is drawn through an apex nozzle outlet. In this manner, the vapor is removed from the carrier gas.

Abstract: A method of separating solids from a slurry or suspension is disclosed. The method includes: providing a slurry or suspension containing solids and liquid to an input port of a first side of a filter, the filter providing a filtering size between 2 microns and 70 microns; providing a liquid discharge port on a second side of the filter which receives the liquid that passes through the filter; and separating the solids from the liquid by pressing the solids into a pressure regulating solids discharge port on the first side of the filter, thereby compacting solids on the first side of the filter, forcing at least some of the liquid of the slurry or suspension through the first side of the filter to the second side of the filter causing pressure regulated solids to be discharged through a pressure regulating solids discharge port into a pressurized chamber.

Abstract: Compounds of formula (I) and salts thereof: wherein R1, R2, R3 and a are as defined herein. Compounds of formula (I) and salts thereof have been found to inhibit the binding of the BET family of bromodomain containing proteins to, for example, acetylated lysine residues and thus may have use in therapy, for example in the treatment of autoimmune and inflammatory diseases, such as rheumatoid arthritis; and cancers.

Abstract: Devices, systems, and methods for removing a component from a fluid are disclosed. A feed fluid is heated by passing the feed fluid through a heating path of a first indirect-contact heat exchanger (ICHE). The feed fluid contains a first component. The fluid is heated from a first temperature to a second temperature, resulting in a heated feed fluid. The heated feed fluid is passed through a desiccator, containing a desiccant. The first component is bound up to the desiccant, resulting in a stripped-heated feed fluid. The stripped-heated feed fluid is cooled by passing the stripped-heated feed fluid through a cooling path of the first indirect-contact heat exchanger (ICHE). The stripped-heated feed fluid is cooled from a second temperature to a third temperature, the third temperature being greater than the first temperature, producing a product fluid.

Abstract: A method for separating a vapor from a carrier gas is disclosed. A hydrocyclone is provided with one or more nozzles on the wall of the hydrocyclone. A cryogenic liquid is provided to the tangential feed inlet at a velocity that induces a tangential flow and a cyclone vortex in the hydrocyclone. The carrier gas is injected into the hydrocyclone through the one or more nozzles. The vapor dissolves, condenses, desublimates, or a combination thereof, forming a vapor-depleted carrier gas and a vapor-enriched cryogenic liquid. The vapor-depleted gas is drawn through the vortex finder while the vapor-enriched cryogenic liquid is drawn through the apex nozzle outlet. In this manner, the vapor is removed from the carrier gas.

Abstract: A method for separating a vapor from a carrier gas is disclosed. An air-sparged hydrocyclone is provided with a porous sparger covered by an outer gas plenum. A cryogenic liquid is provided to the tangential feed inlet at a velocity that induces a tangential flow and a cyclone vortex in the cyclone. The carrier gas is injected into the air-sparged hydrocyclone through the porous sparger. The vapor dissolves, condenses, desublimates, or a combination thereof, forming a vapor-depleted carrier gas and a vapor-enriched cryogenic liquid. The vapor-depleted gas is drawn through a vortex finder while the vapor-enriched cryogenic liquid is drawn through an apex nozzle outlet. In this manner, the vapor is removed from the carrier gas.

Abstract: A method and apparatus for recycling streams in a separations process comprising: determining a measured reading of a parameter of the separations processor is in a suboptimal range; separating, via a separation unit having a volume of contact fluid, the inert gas from the pollutant gas in the inlet flue gas stream to form a clean gas stream and a purified pollutant gas stream; removing at least 1% of the volume of contact fluid to form a removed volume of contact liquid; performing some unit operations on the removed volume of contact fluid; injecting the clean gas stream into the inlet flue gas stream to form a flue gas stream of lower pollutant concentration; and, repeating at progressively lower pollutant concentration, as the inlet stream until the processor determines that a measured reading of the parameter has been returned to a substantially optimal range.