Patents by Inventor Andrew Berlin

Andrew Berlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190315732
    Abstract: The present disclosure relates to bifunctional compounds, which find utility as modulators of Kirsten rat sarcoma protein (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation, accumulation, and/or overactivation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
    Type: Application
    Filed: April 4, 2019
    Publication date: October 17, 2019
    Inventors: Andrew P. Crew, Keith R. Hornberger, Jing Wang, Hanging Dong, Michael Berlin, Craig M. Crews
  • Publication number: 20190300521
    Abstract: The present disclosure relates to bifunctional compounds, which find utility as modulators of SMARCA2 or BRM (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand that binds to the Von Hippel-Lindau E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.
    Type: Application
    Filed: April 1, 2019
    Publication date: October 3, 2019
    Inventors: Andrew P. Crew, Jing Wang, Michael Berlin, Peter Dragovich, Huifen Chen, Leanna Staben
  • Publication number: 20190216445
    Abstract: A system for collecting a sample from a tissue includes a medical instrument having a sample collection region. One or more sensors is configured to detect one or more properties of a sample, and is configured to output at least one measured value representative of the one or more properties of the sample. An indicator is operatively connected to the one or more sensors and is configured to provide a notification to a user of the medical instrument based on the one or more properties of the sample detected by the at least one sensor. A method of guiding sample collection is also provided.
    Type: Application
    Filed: March 28, 2019
    Publication date: July 18, 2019
    Inventors: Andrew A. Berlin, Salil Desai, Thomas Ried, Chris Salthouse
  • Publication number: 20190192229
    Abstract: This invention provides a system and method for guiding a surgical instrument based on information obtained using enhanced contrast-mode ultrasound. The enhanced information can be added to information or images obtained in one or more imaging modes. Various pieces of information can be combined and composited, including information regarding tumors, blood vessels, location information, confidence levels, and other information, and can be composited into operative imaging.
    Type: Application
    Filed: November 21, 2018
    Publication date: June 27, 2019
    Inventors: Andrew A. Berlin, Juergen K. Willmann (Deceased), MD, Mon Y. Young
  • Publication number: 20190162831
    Abstract: This invention provides a system and method for enhancing images acquired by an ultrasound scanner. The system and method employs novel techniques that are compatible with the real-world constraints (i.e. energy levels, duration of exam, geometries involved, etc.) of imaging in mammalian tissue (e.g. tissues of human organs containing lesions/tumors), while providing the dramatically image quality.
    Type: Application
    Filed: November 20, 2018
    Publication date: May 30, 2019
    Inventors: Andrew A. Berlin, Juergen K. Willmann, Mon Y. Young
  • Publication number: 20190154822
    Abstract: This invention provides a system and method for background removal from images acquired by an ultrasound scanner in the presence of molecularly bound contrast agent. The system and method employs novel techniques that are compatible with the real-world constraints (i.e. energy levels, duration of exam, geometries involved, etc.) of imaging in mammalian tissue (e.g. tissues of human organs containing lesions/tumors), while providing the dramatically improved signal clarity required to reliably disambiguate contrast agent from other sources of signal intensity.
    Type: Application
    Filed: July 31, 2018
    Publication date: May 23, 2019
    Inventors: Andrew A. Berlin, Mon Y. Young, Juergen K. Willmann
  • Publication number: 20190154821
    Abstract: This invention provides a system and method for background removal from images acquired by an ultrasound scanner in the presence of molecularly bound contrast agent. The system and method employs novel techniques that are compatible with the real-world constraints (i.e. energy levels, duration of exam, geometries involved, etc.) of imaging in mammalian tissue (e.g. tissues of human organs containing lesions/tumors), while providing the dramatically improved signal clarity required to reliably disambiguate contrast agent from other sources of signal intensity.
    Type: Application
    Filed: July 31, 2018
    Publication date: May 23, 2019
    Inventors: Andrew A. Berlin, Mon Y. Young, Juergen K. Willmann, MD
  • Publication number: 20190122073
    Abstract: This invention provides a system and method to propagate uncertainty information in a deep learning pipeline. It allows for the propagation of uncertainty information from one deep learning model to the next by fusing model uncertainty with the original imagery dataset. This approach results in a deep learning architecture where the output of the system contains not only the prediction, but also the model uncertainty information associated with that prediction. The embodiments herein improve upon existing deep learning-based models (CADe models) by providing the model with uncertainty/confidence information associated with (e.g. CADe) decisions. This uncertainty information can be employed in various ways, including (a) transmitting uncertainty from a first stage (or subsystem) of the machine learning system into a next (second) stage (or the next subsystem), and (b) providing uncertainty information to the end user in a manner that characterizes the uncertainty of the overall machine learning model.
    Type: Application
    Filed: October 23, 2017
    Publication date: April 25, 2019
    Inventors: Onur Ozdemir, Benjamin Woodward, Andrew A. Berlin
  • Publication number: 20190080442
    Abstract: This invention provides a system and method that allows the utilization of computer vision system techniques and processes, such as multi-layer separation and contrast mapping, to enhance the detectability of an imaged tumor, opening the door to real-time tumor tracking and/or modulation of a treatment radiation beam so as to maximize the radiation dosage applied to the tumor itself while minimizing the dosage received by surrounding tissues. The techniques and processes also permit more accurate assessment of the level of radiation dosage delivered to the tumor. An image processor receives the image data from the detector as a plurality of image frames, and performs contrast stretching on the image frames to resolve features. A motion analysis module compares static and dynamic features in the contrast-stretched image frames to derive layers of features. The image frames are output as enhanced image frames. The output can be used to guide the beam.
    Type: Application
    Filed: March 5, 2018
    Publication date: March 14, 2019
    Inventors: Andrew A. Berlin, Christopher L. Williams, PhD, Ross Berbeco, PhD
  • Patent number: 10163195
    Abstract: An image acquisition apparatus configured to receive an adjustable image acquisition parameter, wherein said parameter is adjusted based on an image that has had its subject selectively enhanced via comparison with at least one background reference image.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: December 25, 2018
    Inventors: Andrew Berlin, Rajeev Surati
  • Publication number: 20180249954
    Abstract: This invention provides a system and method for performing a surgical procedure that effectively locates and allows a user to avoid engagement with hidden nerves in tissue in real-time. The system and method employs an integrated stimulating and sensing array. The array includes a plurality of spaced-apart electrodes, which are selectively stimulated while the electrodes then sense for a neural response. Each of the electrodes is stimulated to map of the sensed tissue region for localization of nerve paths. This localization can be stored and used to control cutting of tissue. The locations can be marked as nerve-free and/or no-go regions so as to avoid nerve-containing regions in subsequent procedures or following a stimulation procedure. This marking can be by any acceptable physical and/or virtual fiducial mechanism. The array can be a single structure with all relevant electrodes or some electrodes can be provided in a separate, remote probe assembly.
    Type: Application
    Filed: March 1, 2018
    Publication date: September 6, 2018
    Inventors: Daniel K. Freeman, Andrew A. Berlin, Jesse Wheeler
  • Publication number: 20180249953
    Abstract: This invention provides systems and methods for using spatially localized sensor data to construct a multi-dimensional map of the location of key anatomical features, as well as systems and methods for utilizing this map to present location-based information to the surgeon and/or to an automated surgical navigation system. The location map is updated during surgery, so as to retain accuracy even in the presence of muscle-induced motion or deformation of the anatomy, as well as tissue location changes induced by translations or deformations induced by surgical dissection, surgical instrument contact, or biologically-induced tissue motion associated with activities such as respiration, anesthesia-induced gag reflex, blood flow/pulsation, and/or larger-scale changes in patient posture/positioning.
    Type: Application
    Filed: March 1, 2018
    Publication date: September 6, 2018
    Inventors: Andrew A. Berlin, Philip D. Parks, II
  • Publication number: 20180049728
    Abstract: A system for collecting a sample from a tissue includes a medical instrument having a sample collection region. One or more sensors is configured to detect one or more properties of a sample, and is configured to output at least one measured value representative of the one or more properties of the sample. An indicator is operatively connected to the one or more sensors and is configured to provide a notification to a user of the medical instrument based on the one or more properties of the sample detected by the at least one sensor. A method of guiding sample collection is also provided.
    Type: Application
    Filed: August 22, 2017
    Publication date: February 22, 2018
    Inventors: Andrew A. Berlin, Salil Desai, Thomas Ried, Chris Salthouse
  • Publication number: 20170352131
    Abstract: An image acquisition apparatus configured to receive an adjustable image acquisition parameter, wherein said parameter is adjusted based on an image that has had its subject selectively enhanced via comparison with at least one background reference image.
    Type: Application
    Filed: December 14, 2015
    Publication date: December 7, 2017
    Inventors: Andrew Berlin, Rajeev Surati
  • Publication number: 20170245817
    Abstract: A method of imaging an organism includes introducing a composite nanoparticle into a circulating fluid of an organism to form a circulating fluid mixture in the organism is provided. The composite nanoparticle comprises a core comprising at least one of a contrast agent and a magnetic material, and at least one layer of biocompatible material surrounding the core. The method further includes receiving an image of at least a portion of the organism where the circulating fluid has circulated, removing at least a portion of the circulating fluid mixture from the organism at a first rate, applying a magnetic field to the removed portion of the circulating fluid mixture to selectively remove the composite nanoparticle from the circulating fluid mixture and to produce a filtered fluid mixture, and returning the filtered fluid mixture to the circulating fluid of the organism at a second rate.
    Type: Application
    Filed: February 10, 2017
    Publication date: August 31, 2017
    Inventors: Andrew A. Berlin, Neil Gupta, Rami S. Mangoubi, Adel Malek
  • Publication number: 20160259955
    Abstract: A display window (10) displays items of merchandise in association beacon apparatus (22). The merchandise is provided in Association with display furniture (12) that supports the beacon apparatus (22). The beacon apparatus (22) is short range and carries (24) product and location codes (28, 30) together with app activation codes (26) that cause the portable device (16) to activate an app. The app receives all of the beacon information (24,26, 28,30) and transfer them to an app server which response by providing product outlines to the portable device (16), that enables selection of an item of merchandise for interaction with the app server. A single short range beacon apparatus (22) can provide information for a plurality of items of merchandise. The app server stores all of the beacon (22) location codes and selected product indication codes (30) as statistical evidence of customer preference. The app server permits purchase of items.
    Type: Application
    Filed: November 6, 2014
    Publication date: September 8, 2016
    Inventors: Jonathan Andrew Berlin, Adrian Brian Coe
  • Patent number: 9267944
    Abstract: Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: February 23, 2016
    Assignee: INTEL CORPORATION
    Inventors: Yuegang Zhang, Andrew Berlin, Qing Ma, Li-Peng Wang, Valluri Rao, Mineo Yamakawa
  • Publication number: 20150125965
    Abstract: Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.
    Type: Application
    Filed: January 12, 2015
    Publication date: May 7, 2015
    Inventors: Yuegang Zhang, Andrew Berlin, Qing Ma, Li-Peng Wang, Valluri Rao, Mineo Yamakawa
  • Patent number: 8940234
    Abstract: Systems and methods for detecting the presence of biomolecules in a sample using biosensors that incorporate resonators which have functionalized surfaces for reacting with target biomolecules. In one embodiment, a device includes a piezoelectric resonator having a functionalized surface configured to react with target molecules, thereby changing the mass and/or charge of the resonator which consequently changes the frequency response of the resonator. The resonator's frequency response after exposure to a sample is compared to a reference, such as the frequency response before exposure to the sample, a stored baseline frequency response or a control resonator's frequency response.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: January 27, 2015
    Assignee: Intel Corporation
    Inventors: Yuegang Zhang, Andrew A. Berlin, Qing Ma, Li-Peng Wang, Valluri Rao, Mineo Yamakawa
  • Patent number: 8934683
    Abstract: In certain embodiments of the invention, a plurality of images of one or more subjects may be captured using different imaging techniques, such as different modalities of scanning probe microscopy. Parameters may be estimated from the plurality of images, using one or more models of known molecular structures to provide a model-based analysis. The estimated parameters may be fused, with further input from physical models of known molecular structures. The fused parameters may be used to characterize the subjects. Such characterization may include the detection and/or identification of specific molecular structures, such as proteins, peptides and/or nucleic acids of known sequence and/or structure. In some embodiments of the invention the structural characterizations may be used to identify previously unknown properties of a subject molecule.
    Type: Grant
    Filed: January 26, 2009
    Date of Patent: January 13, 2015
    Assignee: Intel Corporation
    Inventors: Horst Haussecker, Andrew A. Berlin, Selena Chan, Eric Hannah, Narayanan Sundararajan, Mineo Yamakawa