Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

Abstract: A system for reconditioning an ice skate includes an ice skate sharpening assembly having a housing defining a slot, and an ice skate sharpening device positioned within the housing, the slot configured to receive a portion of an ice skate, the portion of the ice skate configured to engage with the ice skate sharpening device. A user interface is in communication with the ice skate sharpening assembly, the user interface is web enabled and configured to communicate through the Internet, the user interface further configured to provide instructions to selectively operate the ice skate sharpening device.