Patents by Inventor Andrew Brearley

Andrew Brearley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CARBOXAMIDE DERIVATIVES
    Publication number: 20230301970
    Abstract: The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: May 16, 2023
    Publication date: September 28, 2023
    Inventors: Kamlesh Jagdis BALA, Andrew BREARLEY, James DALE, Anne-Marie EDWARDS, Mahbub AHMED, David PORTER, Robert Alexander PULZ, Lisa Ann ROONEY, David Andrew SANDHAM, Duncan SHAW, Nichola SMITH, Jessica Louise TAYLOR, Roger John TAYLOR, Thomas Josef TROXLER-SCHWAB, Joe WRIGGLESWORTH
  • Carboxamide derivatives
    Patent number: 11672782
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: November 4, 2020
    Date of Patent: June 13, 2023
    Assignee: NOVARTIS AG
    Inventors: Kamlesh Jagdis Bala, Andrew Brearley, James Dale, Anne-Marie Edwards, Mahbub Ahmed, David Porter, Robert Alexander Pulz, Lisa Ann Rooney, David Andrew Sandham, Duncan Shaw, Nichola Smith, Jessica Louise Taylor, Roger John Taylor, Thomas Josef Troxler, Joe Wrigglesworth
  • INHIBITORS OF SARM1
    Publication number: 20220242859
    Abstract: The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration. In some embodiments, the present disclosure provides certain compounds and/or compositions that are useful in medicine, and particularly for treating neurodegeneration (e.g., for reducing axonal degeneration). In some embodiments, the present disclosure provides compounds having a structure as set forth in Formula (I).
    Type: Application
    Filed: June 5, 2020
    Publication date: August 4, 2022
    Inventors: Robert Owen HUGHES, Rajesh DEVRAJ, Todd BOSANAC, Richard Andrew JARJES-PIKE, Andrew BREARLEY, Jonathan BENTLEY
  • CARBOXAMIDE DERIVATIVES
    Publication number: 20210052554
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: November 4, 2020
    Publication date: February 25, 2021
    Inventors: Kamlesh Jagdis BALA, Andrew BREARLEY, James DALE, Anne-Marie EDWARDS, Mahbub AHMED, David PORTER, Robert Alexander PULZ, Lisa Ann ROONEY, David Andrew SANDHAM, Duncan SHAW, Nichola SMITH, Jessica Louise TAYLOR, Roger John TAYLOR, Thomas Josef Troxler, Joe WRIGGLESWORTH
  • Phenyl amino piperidine mTORC inhibitors and uses thereof
    Patent number: 10844013
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: November 24, 2020
    Assignee: NAVITOR PHARMACEUTICALS, INC.
    Inventors: David John O'Neill, Eddine Saiah, Seong Woo Anthony Kang, Andrew Brearley, Jonathan Bentley
  • CARBOXAMIDE DERIVATIVES
    Publication number: 20200268718
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: May 14, 2020
    Publication date: August 27, 2020
    Inventors: Kamlesh Jagdis BALA, Andrew BREARLEY, James DALE, Anne-Marie EDWARDS, Mahbub AHMED, David PORTER, Robert Alexander PULZ, Lisa Ann ROONEY, David Andrew SANDHAM, Duncan SHAW, Nichola SMITH, Jessica Louise TAYLOR, Roger John TAYLOR, Thomas Josef TROXLER, Joe WRIGGLESWORTH
  • PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF
    Publication number: 20200207716
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: August 7, 2019
    Publication date: July 2, 2020
    Inventors: David John O'Neill, Eddine Saiah, Seong Woo Anthony Kang, Andrew Brearley, Jonathan Bentley
  • PYRROLE mTORC INHIBITORS AND USES THEREOF
    Publication number: 20190389843
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: November 8, 2017
    Publication date: December 26, 2019
    Applicant: Navitor Pharmaceuticals, Inc.
    Inventors: David John O'Neill, Eddine Saiah, Seong Woo Anthony Kang, Andrew Brearley, Jonathan Bentley
  • CARBOXAMIDE DERIVATIVES
    Publication number: 20190381011
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: December 21, 2018
    Publication date: December 19, 2019
    Inventors: Kamlesh Jagdis BALA, Andrew BREARLEY, James DALE, Anne-Marie EDWARDS, Mahbub AHMED, David PORTER, Robert Alexander PULZ, Lisa Ann ROONEY, David Andrew SANDHAM, Duncan SHAW, Nichola SMITH, Jessica Louise TAYLOR, Roger John TAYLOR, Thomas Josef Troxler, Joe WRIGGLESWORTH
  • Phenyl amino piperidine mTORC inhibitors and uses thereof
    Patent number: 10414727
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: September 17, 2019
    Assignee: Navitor Pharmaceuticals, Inc.
    Inventors: David John O'Neill, Eddine Saiah, Seong Woo Anthony Kang, Andrew Brearley, Jonathan Bentley
  • Carboxamide derivatives
    Patent number: 10195181
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: February 5, 2019
    Assignee: Novartis AG
    Inventors: Kamlesh Jagdis Bala, Andrew Brearley, James Dale, Anne-Marie Edwards, Mahbub Ahmed, David Porter, Robert Alexander Pulz, Lisa Ann Rooney, David Andrew Sandham, Duncan Shaw, Nichola Smith, Jessica Louise Taylor, Roger John Taylor, Thomas Josef Troxler, Joe Wrigglesworth
  • PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF
    Publication number: 20180127370
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: November 8, 2017
    Publication date: May 10, 2018
    Inventors: David John O'Neill, Eddine Saiah, Seong Woo Anthony Kang, Andrew Brearley, Jonathan Bentley
  • CARBOXAMIDE DERIVATIVES
    Publication number: 20170014388
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: June 16, 2016
    Publication date: January 19, 2017
    Applicant: NOVARTIS AG
    Inventors: Kamlesh Jagdis BALA, Andrew BREARLEY, James DALE, Anne-Marie EDWARDS, Mahbub AHMED, David PORTER, Robert Alexander PULZ, Lisa Ann ROONEY, David Andrew SANDHAM, Duncan SHAW, Nichola SMITH, Jessica Louise TAYLOR, Roger John TAYLOR, Thomas Josef Troxler, Joe WRIGGLESWORTH
  • Carboxamide derivatives
    Patent number: 9403810
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: August 2, 2016
    Assignee: Novartis AG
    Inventors: Kamlesh Jagdis Bala, Andrew Brearley, James Dale, Anne-Marie Edwards, Mahbub Ahmed, David Porter, Robert Alexander Pulz, Lisa Ann Rooney, David Andrew Sandham, Duncan Shaw, Nichola Smith, Jessica Louise Taylor, Roger John Taylor, Thomas Josef Troxler, Joe Wrigglesworth