Patents by Inventor Andrew C. Adey

Andrew C. Adey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SINGLE CELL WHOLE GENOME LIBRARIES AND COMBINATORIAL INDEXING METHODS OF MAKING THEREOF
    Publication number: 20230323426
    Abstract: Provided herein are methods for preparing a sequencing library that includes nucleic acids from a plurality of single cells. In one embodiment, the sequencing library includes whole genome nucleic acids from the plurality of single cells. In one embodiment, the method includes generating nucleosome-depleted nuclei by chemical treatment while maintaining integrity of the nuclei. Also provided herein are compositions, such as compositions that include chemically treated nucleosome-depleted isolated nuclei.
    Type: Application
    Filed: December 5, 2022
    Publication date: October 12, 2023
    Applicants: Illumina Inc., Oregon Health & Science University
    Inventors: Andrew C. Adey, Sarah A. Vitak, Frank J. Steemers
  • Single cell whole genome libraries and combinatorial indexing methods of making thereof
    Patent number: 11535883
    Abstract: Provided herein are methods for preparing a sequencing library that includes nucleic acids from a plurality of single cells. In one embodiment, the sequencing library includes whole genome nucleic acids from the plurality of single cells. In one embodiment, the method includes generating nucleosome-depleted nuclei by chemical treatment while maintaining integrity of the nuclei. Also provided herein are compositions, such as compositions that include chemically treated nucleosome-depleted isolated nuclei.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: December 27, 2022
    Assignees: Illumina, Inc., Oregon Health & Science University
    Inventors: Andrew C. Adey, Sarah A. Vitak, Frank J. Steemers
  • METHODS FOR INCREASING YIELD OF SEQUENCING LIBRARIES
    Publication number: 20210380972
    Abstract: The present disclosure is concerned with compositions, methods, and kits for preparing a sequencing library. In one embodiment, methods include producing a library of target nucleic acids having the same adapter at each end and then switching the identity of one adapter to result in target nucleic acids flanked by distinct adapters.
    Type: Application
    Filed: June 10, 2021
    Publication date: December 9, 2021
    Applicants: Illumina, Inc., Illumina Cambridge Limited, Oregon Health & Science University
    Inventors: Andrew C. Adey, Ryan Mulqueen, Frank Steemers, Dmitry K Pokholok, Fan Zhang, Esther Musgrave-Brown
  • SINGLE CELL WHOLE GENOME LIBRARIES FOR METHYLATION SEQUENCING
    Publication number: 20180355348
    Abstract: Provided herein are methods for preparing sequencing libraries for determining the methylation status of nucleic acids from a plurality of single cells. The present methods combine split-and-pool combinatorial indexing and bisulfite treatment techniques to characterize the methylation profiles of large numbers of single cells quickly, accurately and inexpensively.
    Type: Application
    Filed: June 5, 2018
    Publication date: December 13, 2018
    Applicants: OREGON HEALTH & SCIENCE UNIVERSITY, ILLUMINA, INC.
    Inventors: Andrew C. Adey, Ryan Mulqueen, Frank J. Steemers, Dmitry K. Pokholok, Steven Norberg
  • SINGLE CELL WHOLE GENOME LIBRARIES AND COMBINATORIAL INDEXING METHODS OF MAKING THEREOF
    Publication number: 20180023119
    Abstract: Provided herein are methods for preparing a sequencing library that includes nucleic acids from a plurality of single cells. In one embodiment, the sequencing library includes whole genome nucleic acids from the plurality of single cells. In one embodiment, the method includes generating nucleosome-depleted nuclei by chemical treatment while maintaining integrity of the nuclei. Also provided herein are compositions, such as compositions that include chemically treated nucleosome-depleted isolated nuclei.
    Type: Application
    Filed: July 21, 2017
    Publication date: January 25, 2018
    Applicants: Illumina, Inc., Oregon Health & Science University
    Inventors: Andrew C. Adey, Sarah A. Vitak, Frank J. Steemers