Patents by Inventor Andrew C. Kruegel

Andrew C. Kruegel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Opioid receptor modulators
    Patent number: 11840541
    Abstract: The present invention provides a compound having the structure wherein A is a ring structure, with or without substitution; X1 is C or N; X2 is N, O, or S; Y1 is H, -(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 2 is H, -(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y3 is H-(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 4 is H-(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y5 is H, -(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); a and P are each present or absent and when present each is a bond.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: December 12, 2023
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Andrew C. Kruegel, Madalee G. Wulf, Jonathan A. Javitch, Dalibor Sames
  • Mitragynine analogs for the treatment of pain, mood disorders and substance use disorders
    Patent number: 11760758
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with pain, a depressive disorder, a mood disorder or an anxiety disorder by administering the compound to the subject.
    Type: Grant
    Filed: February 16, 2021
    Date of Patent: September 19, 2023
    Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC., SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
    Inventors: Andrew C. Kruegel, Dalibor Sames, Srijita Bhowmik, Vaclav Havel, Juraj Galeta, Jonathan A. Javitch, Susruta Majumdar
  • OPIOID RECEPTOR MODULATORS
    Publication number: 20230271976
    Abstract: The present invention provides a compound having the structure wherein A is a ring structure, with or without substitution; X1 is C or N; X2 is N, O, or S; Y1 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 2 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y3 is H-(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 4 is H-(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y5 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); a and P are each present or absent and when present each is a bond.
    Type: Application
    Filed: April 7, 2023
    Publication date: August 31, 2023
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Andrew C. Kruegel, Madalee G. Wulf, Jonathan A. Javitch, Dalibor Sames
  • DEUTERATED MITRAGYNINE ANALOGS AS SAFER OPIOID MODULATORS IN THE MITRAGYNINE CLASS
    Publication number: 20220135564
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and methods of using the compound to treat pain, depressive disorders, mood disorders, anxiety disorders, opioid use disorder, and opioid withdrawal symptoms.
    Type: Application
    Filed: January 30, 2020
    Publication date: May 5, 2022
    Applicants: The Trustees of Columbia University in the City of New York, The Research Foundation for Mental Hygiene, Inc., Sloan-Kettering Institute for Cancer Research
    Inventors: Andrew C. Kruegel, Dalibor Sames, Jonathan A. Javitch, Susruta Majumdar
  • CLASS OF MU-OPIOID RECEPTOR AGONISTS
    Publication number: 20220106279
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof.
    Type: Application
    Filed: July 6, 2021
    Publication date: April 7, 2022
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Andrew C. Kruegel, Adam Henke, Madalee G. Wulf, Marie-Laure Rives, Jonathan A. Javitch, Dalibor Sames
  • MITRAGYNINE ANALOGS FOR THE TREATMENT OF PAIN, MOOD DISORDERS AND SUBSTANCE USE DISORDERS
    Publication number: 20210179619
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof, and a method of treating a subject afflicted with pain, a depressive disorder, a mood disorder or an anxiety disorder by administering the compound to the subject.
    Type: Application
    Filed: February 16, 2021
    Publication date: June 17, 2021
    Applicants: The Trustees of Columbia University in the City of New York, The Research Foundation for Mental Hygiene, Inc., Sloan-Kettering Institute for Cancer Research
    Inventors: Andrew C. Kruegel, Dalibor Sames, Srijita Bhowmik, Vaclav Havel, Juraj Galeta, Jonathan A. Javitch, Susruta Majumdar
  • NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS
    Publication number: 20190084949
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof.
    Type: Application
    Filed: November 16, 2018
    Publication date: March 21, 2019
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Andrew C. Kruegel, Adam Henke, Madalee M. Wulf, Marie-Laure Rives, Jonathan A. Javitch, Dalibor Sames
  • Class of mu-opioid receptor agonists
    Patent number: 10183919
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: January 22, 2019
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Andrew C. Kruegel, Adam Henke, Madalee M. Gassaway, Marie-Laure Rives, Jonathan A. Javitch, Dalibor Sames
  • OPIOID RECEPTOR MODULATORS
    Publication number: 20170334923
    Abstract: The present invention provides a compound having the structure wherein A is a ring structure, with or without substitution; X1 is C or N; X2 is N, O, or S; Y1 is H, -(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 2 is H, -(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y3 is H-(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 4 is H-(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y5 is H, -(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); a and P are each present or absent and when present each is a bond.
    Type: Application
    Filed: November 25, 2015
    Publication date: November 23, 2017
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Andrew C. KRUEGEL, Madalee M. GASSAWAY, Jonathan A. JAVITCH, Dalibor SAMES
  • A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS
    Publication number: 20170217913
    Abstract: The present invention provides a compound having the structure: or a pharmaceutically acceptable salt or ester thereof.
    Type: Application
    Filed: March 12, 2015
    Publication date: August 3, 2017
    Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Andrew C. Kruegel, Adam Henke, Madalee M. Gassaway, Marie-Laure Rives, Jonathan A. Javitch, Dalibor Sames