Abstract: An apparatus for containing a three-dimensional cellular material surrounded by a medium that facilitates and maintains the centering of the three-dimensional cellular material throughout an assay is provided. The apparatus includes a well having an open proximal end and a closed distal end. Further, the well defines a compartment having an interior surface and a sample nesting site for containing the three-dimensional cellular material surrounded by the medium. A central indentation is located at the closed distal end of the well, a first concentric lip is located above the central indentation in a y-direction towards the open proximal end of the well, and a second concentric lip is located above the first concentric lip in the y-direction towards the open proximal end of the well. Additionally, the first concentric lip and the second concentric lip define a groove therebetween. A method of forming a three-dimensional cellular material is also provided.

Abstract: An analytical instrument having a sensing system, a stage adapted to receive a sample carrier, a motion actuator assembly for positioning the sensing system and/or the stage, a temperature control element, and a signal processing module are disclosed. Methods of analyzing cell samples with the analytical instrument are also disclosed.

Abstract: The present disclosure relates to methods and apparatus for measuring of multiple physiological properties of biological samples, such as measuring biological flux.

Abstract: The present disclosure relates to methods and apparatus for measuring of multiple physiological properties of biological samples, such as measuring biological flux.

Abstract: An apparatus for calibrating a flux analyzer comprises a first frame; a second frame; and a permeable membrane. The first frame and the second frame are connected or integrally formed. A method for calibrating a flux analyzer is provided which uses an artificial standard rather than a biological standard.

Abstract: The present disclosure relates to methods and apparatus for measuring of multiple physiological properties of biological samples, such as measuring biological flux.

Abstract: An apparatus for calibrating a flux analyzer comprises a first frame; a second frame; and a permeable membrane. The first frame and the second frame are connected or integrally formed. A method for calibrating a flux analyzer is provided which uses an artificial standard rather than a biological standard.

Abstract: An infrared video camera system comprises an uncooled infrared sensor mounted and a thermally conductive thin walled radiation shield for shielding radiation from reaching an active surface of the uncooled infrared sensor. A TEC maintains the sensor active surface and the radiation shield at a substantially constant temperature. The uncooled infrared sensor and radiation shield are further housed in a hollow thermally conductive vacuum cover which is vacuum sealed with a base assembly and includes a vacuum sealed infrared transparent window in an aperture at a top end of the vacuum cover for allowing infrared radiation to reach the active surface and for forming a vacuum chamber enclosing the infrared sensor and radiation shield. A relay optical cell mounted to a camera body comprises at least one optical element for relaying an image formed at its entrance onto the active surface.