Patents by Inventor Andrew Camilli

Andrew Camilli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170051311
    Abstract: The present invention includes compositions and methods of co-transformation of naturally competent cells. In one aspect of the invention, a method is included for introducing nucleic acid sequences into one or more naturally competent cells in parallel. In other aspects, a heterogenic pool of co-transformed naturally competent cells and an apparatus for introducing two or more populations of nucleic acid sequences into a population of naturally competent cells in parallel are also included.
    Type: Application
    Filed: May 1, 2015
    Publication date: February 23, 2017
    Applicant: TUFTS UNIVERSITY
    Inventors: ANKUR B. DALIA, ANDREW CAMILLI
  • Publication number: 20150203887
    Abstract: According to some aspects of the invention, provided herein are methods of amplifying nucleic acids using homopolymer-dedicated ligation. The methods, in some embodiments, comprise adding a first homopolymer of at least 12 nucleotides to each 3? end of blunt-ended double-stranded nucleic acid containing a target nucleic acid, thereby producing a partially double-stranded nucleic acid.
    Type: Application
    Filed: August 23, 2013
    Publication date: July 23, 2015
    Applicant: Tufts University
    Inventors: David W. Lazinski, Andrew Camilli
  • Patent number: 8642046
    Abstract: The methods and compositions of the present invention are directed to a vaccine against Vibrio cholerae comprised of V. cholerae outer membrane vesicles (OMVs). Such vaccines are relatively stable, facilitating distribution. Inventive methods generally include administration of a vaccine against Vibrio cholerae by intranasal, intraperitoneal, oral or intragastric routes. Such vaccines confer immunity to the individual, and when administered to pregnant subjects, can be conferred to the offspring of individuals.
    Type: Grant
    Filed: October 9, 2008
    Date of Patent: February 4, 2014
    Assignee: Tufts University
    Inventors: Andrew Camilli, Stefan Schild, Eric Jorge Nelson
  • Publication number: 20100247566
    Abstract: The methods and compositions of the present invention are directed to a vaccine against Vibrio cholerae comprised of V. cholerae outer membrane vesicles (OMVs). Such vaccines are relatively stable, facilitating distribution. Inventive methods generally include administration of a vaccine against Vibrio cholerae by intranasal, intraperitoneal, oral or intragastric routes. Such vaccines confer immunity to the individual, and when administered to pregnant subjects, can be conferred to the offspring of individuals.
    Type: Application
    Filed: October 9, 2008
    Publication date: September 30, 2010
    Applicant: TUFTS UNIVERSITY
    Inventors: Andrew Camilli, Stefan Schild, Eric Jorge Nelson
  • Patent number: 6207384
    Abstract: The invention features a general system for the identification of essential genes in organisms. This system is applicable to the discovery of novel target genes for antimicrobial compounds, as well as to the discovery of genes that enhance cell growth or viability.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: March 27, 2001
    Assignees: The General Hospital Corporation, Trustees of Tufts College, President and Fellows of Harvard College
    Inventors: John J. Mekalanos, Brian J. Akerley, Eric J. Rubin, Andrew Camilli
  • Patent number: 6203799
    Abstract: V. cholerae vaccine strains which have a soft agar penetration-defective phenotype and methods for making such strains are described. Also described are methods for identifying new genes involved in V. cholerae motility and the cloning, identification, and sequencing of V. cholerae motB and fliC genes.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: March 20, 2001
    Assignee: Presidents and Fellows of Harvard College
    Inventors: John J. Mekalanos, Claudette L. Gardel, Andrew Camilli
  • Patent number: 5571688
    Abstract: A reporter system relating to in vivo expression technology was devised to aid in the identification and study of genes that display temporal or spatial patterns of expression during infection of host tissues. The method of this invention comprises constructing a strain or pool of strains of a microorganism which contains an artificial cointegrate comprising a reporter gene flanked by direct repeats of sequences to which a resolvase enzyme binds, thus catalyzing excision of the reporter gene, and further contains a coding sequence under the control of a promoter sequence which encodes transcripts, the expression of which are easily monitored in vitro and which result in a permanent genetic change, excision of the reporter gene, that is heritable and easily detectable subsequent to induction of the synthetic operon.
    Type: Grant
    Filed: February 27, 1995
    Date of Patent: November 5, 1996
    Inventors: John J. Mekalanos, Andrew Camilli
  • Patent number: 5512452
    Abstract: A reporter system relating to in vivo expression technology was devised to aid in the identification and study of genes that display temporal or spatial patterns of expression during infection of host tissues. The method of this invention comprises integrating a site-specific DNA recombinase expression vector, and a reporter gene that is permanently removable by the recombinase, by way of homologous recombination into a microorganism's chromosome and inducing the expression of a synthetic operon which encodes transcripts, the expression of which are easily monitored in vitro and which result in a permanent genetic change, excision of the reporter gene, that is heritable and easily detectable subsequent to induction of the synthetic operon.
    Type: Grant
    Filed: September 28, 1993
    Date of Patent: April 30, 1996
    Assignee: President and Fellows of Harvard College
    Inventors: John J. Mekalanos, Andrew Camilli